DegronMD

Uniprot ID: Q7KZI7

Source protein: Serine/threonine-protein kinase MARK2

Source gene: MARK2

Class: DEG_SPOP_SBC_1

Location: 475:479

E3 ligase: SPOP

DEGRON score: 0.9918

ASA_SCORE: 95.26

COIL: 0.951

CONS_SCORE: 0.2954

DSS_SCORE: 0.7121

HELIX: 0.0234

FCONS_SCORE: 1.0311

RIG_SCORE: 0.6751

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P487S	TCGA-EE-A2MI	SKCM	TCGA	VLSTS	DEG_SPOP_SBC_1	0.1111
p.S480Y	DO6275	CESC	ICGC	VLSTS	DEG_SPOP_SBC_1	0.3056
p.V474I	DO233865	GACA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.3056
p.Q467H	DO26488	LUSC	ICGC	VLSTS	DEG_SPOP_SBC_1	0.5556
p.P475L	DO27381	LUSC	ICGC	VLSTS	DEG_SPOP_SBC_1	0.7582
p.P469S	DO222702	MELA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.6111
p.T482M	DO51766	STAD	ICGC	VLSTS	DEG_SPOP_SBC_1	0.25
p.A484V	ACH-000994	Endometrial/Uterine Cancer	CCLE	VLSTS	DEG_SPOP_SBC_1	0.1944
p.R477W	MES-SA	soft_tissue	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1481:1485	VLSTS	SPOP	0.7831	More...
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	334:338	VLSTS	SPOP	0.5966	More...
Q32MK0	Myosin light chain kinase 3	DEG_SPOP_SBC_1	174:178	VLSTS	SPOP	0.9947	More...
Q6IPM2	IQ domain-containing protein E	DEG_SPOP_SBC_1	318:322	VLSTS	SPOP	0.5759	More...
Q6ZMZ0	E3 ubiquitin-protein ligase RNF19B	DEG_SPOP_SBC_1	492:496	VLSTS	SPOP	0.944	More...
Q7KZI7	Serine/threonine-protein kinase MARK2	DEG_SPOP_SBC_1	475:479	VLSTS	SPOP	0.9918	More...
Q7Z460	CLIP-associating protein 1	DEG_SPOP_SBC_1	793:797	VLSTS	SPOP	0.9931	More...
Q8TEJ3	E3 ubiquitin-protein ligase SH3RF3	DEG_SPOP_SBC_1	696:700	VLSTS	SPOP	0.9715	More...
Q92540	Nonsense-mediated mRNA decay factor SMG7	DEG_SPOP_SBC_1	526:530	VLSTS	SPOP	0.9999	More...
Q96LA8	Protein arginine N-methyltransferase 6	DEG_SPOP_SBC_1	306:310	VLSTS	SPOP	0.5624	More...
Q9H0E7	Ubiquitin carboxyl-terminal hydrolase 44	DEG_SPOP_SBC_1	245:249	VLSTS	SPOP	0.9886	More...
Q9P275	Ubiquitin carboxyl-terminal hydrolase 36	DEG_SPOP_SBC_1	578:582	VLSTS	SPOP	0.9967	More...
Q9UNZ2	NSFL1 cofactor p47	DEG_SPOP_SBC_1	267:271	VLSTS	SPOP	0.7502	More...
Q5T8P6	RNA-binding protein 26	DEG_SPOP_SBC_1	687:691	VLSTS	SPOP	0.5563	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons