DegronMD

Uniprot ID: Q32MK0

Source protein: Myosin light chain kinase 3

Source gene: MYLK3

Class: DEG_SPOP_SBC_1

Location: 174:178

E3 ligase: SPOP

DEGRON score: 0.9947

ASA_SCORE: 75.1

COIL: 0.819

CONS_SCORE: 0.5487

DSS_SCORE: 0.7471

HELIX: 0.0732

FCONS_SCORE: 1.3479

RIG_SCORE: 0.6425

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P187S	TCGA-B5-A3FA	UCEC	TCGA	VLSTS	DEG_SPOP_SBC_1	0.0833
p.P187S	DO52402	UCEC	ICGC	VLSTS	DEG_SPOP_SBC_1	0.0833
p.G169E	TCGA-BH-A0EB	BRCA	TCGA	VLSTS	DEG_SPOP_SBC_1	0.1944
p.G169E	DO1284	BRCA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.1944
p.P171L	TCGA-D3-A3C7	SKCM	TCGA	VLSTS	DEG_SPOP_SBC_1	0.25
p.P171L	DO47569	SKCM	ICGC	VLSTS	DEG_SPOP_SBC_1	0.25
p.S176N	TCGA-EO-A22R	UCEC	TCGA	VLSTS	DEG_SPOP_SBC_1	0.7069
p.S176N	DO42713	UCEC	ICGC	VLSTS	DEG_SPOP_SBC_1	0.7069
p.E186K	TCGA-GV-A3QH	BLCA	TCGA	VLSTS	DEG_SPOP_SBC_1	0.1111
p.E186K	DO464	BLCA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.1111
p.S169C	DO856	BLCA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.1944
p.A184D	DO229015	LICA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.1667
p.E178K	DO222731	MELA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.7022
p.L175Q	DO48944	PBCA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.6654
p.E186Q	SIDM00704	Small Cell Lung Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.1111
p.E186Q	ACH-000639	Lung Cancer	CCLE	VLSTS	DEG_SPOP_SBC_1	0.1111
p.E186Q	NCI-H211	lung	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.1111
p.R184Q	ACH-000599	Pancreatic Cancer	CCLE	VLSTS	DEG_SPOP_SBC_1	0.1667
p.R184Q	PA-TU-8902	pancreas	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.1667
p.G183C	DOHH-2	haematopoietic_and_lymphoid_tissue	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1481:1485	VLSTS	SPOP	0.7831	More...
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	334:338	VLSTS	SPOP	0.5966	More...
Q32MK0	Myosin light chain kinase 3	DEG_SPOP_SBC_1	174:178	VLSTS	SPOP	0.9947	More...
Q6IPM2	IQ domain-containing protein E	DEG_SPOP_SBC_1	318:322	VLSTS	SPOP	0.5759	More...
Q6ZMZ0	E3 ubiquitin-protein ligase RNF19B	DEG_SPOP_SBC_1	492:496	VLSTS	SPOP	0.944	More...
Q7KZI7	Serine/threonine-protein kinase MARK2	DEG_SPOP_SBC_1	475:479	VLSTS	SPOP	0.9918	More...
Q7Z460	CLIP-associating protein 1	DEG_SPOP_SBC_1	793:797	VLSTS	SPOP	0.9931	More...
Q8TEJ3	E3 ubiquitin-protein ligase SH3RF3	DEG_SPOP_SBC_1	696:700	VLSTS	SPOP	0.9715	More...
Q92540	Nonsense-mediated mRNA decay factor SMG7	DEG_SPOP_SBC_1	526:530	VLSTS	SPOP	0.9999	More...
Q96LA8	Protein arginine N-methyltransferase 6	DEG_SPOP_SBC_1	306:310	VLSTS	SPOP	0.5624	More...
Q9H0E7	Ubiquitin carboxyl-terminal hydrolase 44	DEG_SPOP_SBC_1	245:249	VLSTS	SPOP	0.9886	More...
Q9P275	Ubiquitin carboxyl-terminal hydrolase 36	DEG_SPOP_SBC_1	578:582	VLSTS	SPOP	0.9967	More...
Q9UNZ2	NSFL1 cofactor p47	DEG_SPOP_SBC_1	267:271	VLSTS	SPOP	0.7502	More...
Q5T8P6	RNA-binding protein 26	DEG_SPOP_SBC_1	687:691	VLSTS	SPOP	0.5563	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons