DegronMD - Q6IPM2(IQCE)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D316Y	TCGA-85-7710	LUSC	TCGA	VLSTS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.2778
p.K691N	TCGA-CA-6717	COAD	TCGA	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation altering degron motif	0.5806
p.K691N	TCGA-D1-A16X	UCEC	TCGA	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation altering degron motif	0.5806
p.K691N	TCGA-E6-A1LX	UCEC	TCGA	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation altering degron motif	0.5806
p.P323T	TCGA-DF-A2KN	UCEC	TCGA	VLSTS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.3056
p.V674I	TCGA-QA-A7B7	LIHC	TCGA	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation rewiring degron network	0.0556
p.R327C	DO8842	COAD	ICGC	VLSTS	DEG_SPOP_SBC_1	318:322	Mutation substituting flanking lysine	0.3056
p.A312V	DO230312	COCA	ICGC	VLSTS	DEG_SPOP_SBC_1	318:322	Mutation blocking ubiquitination signal	0.6111
p.A308S	DO229034	LICA	ICGC	VLSTS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.0556
p.R327H	DO231075	LUSC	ICGC	VLSTS	DEG_SPOP_SBC_1	318:322	Mutation substituting flanking lysine	0.3056
p.P317R	DO49080	PACA	ICGC	VLSTS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.3056
p.D681N	SIDM02055	Colorectal Carcinoma	GDSC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation rewiring degron network	0.25
p.R317C	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.3056
p.R317C	SIDM01117	Small Cell Lung Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.3056
p.R317C	SIDM00855	Other Sarcomas	GDSC	VLSTS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.3056
p.R317C	SIDM00087	Plasma Cell Myeloma	GDSC	VLSTS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.3056
p.R317C	SIDM00654	Small Cell Lung Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.3056
p.R317C	SIDM01112	Osteosarcoma	GDSC	VLSTS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.3056
p.R317C	SIDM00529	Breast Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.3056
p.R317C	SIDM01173	Rhabdomyosarcoma	GDSC	VLSTS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.3056
p.R317C	SIDM00628	Breast Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.3056
p.R317C	SIDM01409	Bladder Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.3056
p.Q675H	SIDM00697	Small Cell Lung Carcinoma	GDSC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation rewiring degron network	0.0833
p.Q675H	NCI-H1436	lung	COSMIC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation rewiring degron network	0.0833
p.R685W	SIDM01040	Ovarian Carcinoma	GDSC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation altering degron motif	0.8634
p.R685W	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation altering degron motif	0.8634
p.R685W	SIDM00555	Glioblastoma	GDSC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation altering degron motif	0.8634
p.R685W	SIDM00273	Glioblastoma	GDSC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation altering degron motif	0.8634
p.R685W	KS-1	central nervous system	COSMIC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation altering degron motif	0.8634
p.R685W	GI-1	central nervous system	COSMIC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation altering degron motif	0.8634
p.R685W	FU-OV-1	ovary	COSMIC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation altering degron motif	0.8634
p.R685W	JEKO-1	haematopoietic and lymphoid tissue	COSMIC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation altering degron motif	0.8634
p.V694M	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation altering degron motif	0.7208
p.V694M	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation altering degron motif	0.7208
p.I682T	SIDM00556	Neuroblastoma	GDSC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation rewiring degron network	0.2778
p.I682T	ACH-000227	Neuroblastoma	CCLE	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation rewiring degron network	0.2778
p.I682T	KP-N-YN	autonomic ganglia	COSMIC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation rewiring degron network	0.2778
p.L311R	SIDM00241	Breast Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1389
p.L311R	ACH-002179	Breast Cancer	CCLE	VLSTS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1389
p.L311R	OCUB-M	breast	COSMIC	VLSTS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1389
p.G692R	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation altering degron motif	0.7568
p.G692R	HCC-15	lung	COSMIC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation altering degron motif	0.7568
p.S688L	SIDM01619	Endometrial Carcinoma	GDSC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation altering degron motif	0.7667
p.N308S	ACH-000982	Colon/Colorectal Cancer	CCLE	VLSTS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.0556
p.G676R	HCC-15	lung	COSMIC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation rewiring degron network	0.1111
p.L324P	NB1	autonomic ganglia	COSMIC	VLSTS	DEG_SPOP_SBC_1	318:322	Mutation blocking phosphorylation signal	0.7222
p.V678M	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	684:695	Mutation rewiring degron network	0.1667
p.S315L	SK-OV-3	ovary	COSMIC	VLSTS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IQCE

UniProt ID: Q6IPM2

Entrez ID: 23288

Protein name: IQ domain-containing protein E

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IQCE in