DegronMD

Uniprot ID: Q6IPM2

Source protein: IQ domain-containing protein E

Source gene: IQCE

Class: DEG_SPOP_SBC_1

Location: 318:322

E3 ligase: SPOP

DEGRON score: 0.5759

ASA_SCORE: 74.16

COIL: 0.5208

CONS_SCORE: 0.6831

DSS_SCORE: 0.4093

HELIX: 0.4682

FCONS_SCORE: 0.9666

RIG_SCORE: 0.7358

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D316Y	TCGA-85-7710	LUSC	TCGA	VLSTS	DEG_SPOP_SBC_1	0.2778
p.P323T	TCGA-DF-A2KN	UCEC	TCGA	VLSTS	DEG_SPOP_SBC_1	0.3056
p.R327C	DO8842	COAD	ICGC	VLSTS	DEG_SPOP_SBC_1	0.3056
p.A312V	DO230312	COCA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.6111
p.A308S	DO229034	LICA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.0556
p.R327H	DO231075	LUSC	ICGC	VLSTS	DEG_SPOP_SBC_1	0.3056
p.P317R	DO49080	PACA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.3056
p.R317C	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.3056
p.R317C	SIDM01117	Small Cell Lung Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.3056
p.R317C	SIDM00855	Other Sarcomas	GDSC	VLSTS	DEG_SPOP_SBC_1	0.3056
p.R317C	SIDM00087	Plasma Cell Myeloma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.3056
p.R317C	SIDM00654	Small Cell Lung Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.3056
p.R317C	SIDM01112	Osteosarcoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.3056
p.R317C	SIDM00529	Breast Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.3056
p.R317C	SIDM01173	Rhabdomyosarcoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.3056
p.R317C	SIDM00628	Breast Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.3056
p.R317C	SIDM01409	Bladder Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.3056
p.L311R	SIDM00241	Breast Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.1389
p.L311R	ACH-002179	Breast Cancer	CCLE	VLSTS	DEG_SPOP_SBC_1	0.1389
p.L311R	OCUB-M	breast	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.1389
p.N308S	ACH-000982	Colon/Colorectal Cancer	CCLE	VLSTS	DEG_SPOP_SBC_1	0.0556
p.L324P	NB1	autonomic_ganglia	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.7222
p.S315L	SK-OV-3	ovary	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1481:1485	VLSTS	SPOP	0.7831	More...
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	334:338	VLSTS	SPOP	0.5966	More...
Q32MK0	Myosin light chain kinase 3	DEG_SPOP_SBC_1	174:178	VLSTS	SPOP	0.9947	More...
Q6IPM2	IQ domain-containing protein E	DEG_SPOP_SBC_1	318:322	VLSTS	SPOP	0.5759	More...
Q6ZMZ0	E3 ubiquitin-protein ligase RNF19B	DEG_SPOP_SBC_1	492:496	VLSTS	SPOP	0.944	More...
Q7KZI7	Serine/threonine-protein kinase MARK2	DEG_SPOP_SBC_1	475:479	VLSTS	SPOP	0.9918	More...
Q7Z460	CLIP-associating protein 1	DEG_SPOP_SBC_1	793:797	VLSTS	SPOP	0.9931	More...
Q8TEJ3	E3 ubiquitin-protein ligase SH3RF3	DEG_SPOP_SBC_1	696:700	VLSTS	SPOP	0.9715	More...
Q92540	Nonsense-mediated mRNA decay factor SMG7	DEG_SPOP_SBC_1	526:530	VLSTS	SPOP	0.9999	More...
Q96LA8	Protein arginine N-methyltransferase 6	DEG_SPOP_SBC_1	306:310	VLSTS	SPOP	0.5624	More...
Q9H0E7	Ubiquitin carboxyl-terminal hydrolase 44	DEG_SPOP_SBC_1	245:249	VLSTS	SPOP	0.9886	More...
Q9P275	Ubiquitin carboxyl-terminal hydrolase 36	DEG_SPOP_SBC_1	578:582	VLSTS	SPOP	0.9967	More...
Q9UNZ2	NSFL1 cofactor p47	DEG_SPOP_SBC_1	267:271	VLSTS	SPOP	0.7502	More...
Q5T8P6	RNA-binding protein 26	DEG_SPOP_SBC_1	687:691	VLSTS	SPOP	0.5563	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons