DegronMD - Q7KZI7(MARK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L21F	TCGA-05-4396	LUAD	TCGA	ARTPLPTLN	DEG_APCC_DBOX_1	4:12	Mutation rewiring degron network	0.0833
p.L21F	DO23838	LUAD	ICGC	ARTPLPTLN	DEG_APCC_DBOX_1	4:12	Mutation rewiring degron network	0.0833
p.P326L	TCGA-69-7979	LUAD	TCGA	LKPYVE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.1111
p.P326L	DO23874	LUAD	ICGC	LKPYVE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.1111
p.E309K	TCGA-AA-3833	COAD	TCGA	LKPYVE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.2222
p.E309K	TCGA-AP-A056	UCEC	TCGA	LKPYVE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.2222
p.R327Q	TCGA-BP-4961	KIRC	TCGA	LKPYVE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.0833
p.P487S	TCGA-EE-A2MI	SKCM	TCGA	VLSTS	DEG_SPOP_SBC_1	475:479	Mutation rewiring degron network	0.1111
p.D325E	TCGA-XM-AAZ2	THYM	TCGA	LKPYVE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.1389
p.E729Q	TCGA-ZJ-AAXT	CESC	TCGA	MHGTPGHE	DEG_SCF_FBW7_2	736:743	Mutation rewiring degron network	0.1389
p.S480Y	DO6275	CESC	ICGC	VLSTS	DEG_SPOP_SBC_1	475:479	Mutation rewiring degron network	0.3056
p.L328M	DO7776	COAD	ICGC	LKPYVE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.0556
p.E308D	DO8842	COAD	ICGC	LKPYVE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.1944
p.T16A	DO234463	ESAD	ICGC	ARTPLPTLN	DEG_APCC_DBOX_1	4:12	Mutation rewiring degron network	0.2222
p.V474I	DO233865	GACA	ICGC	VLSTS	DEG_SPOP_SBC_1	475:479	Mutation rewiring degron network	0.3056
p.R21L	DO229019	LICA	ICGC	ARTPLPTLN	DEG_APCC_DBOX_1	4:12	Mutation rewiring degron network	0.0833
p.G315V	DO229028	LICA	ICGC	LKPYVE	LIG_APCC_ABBA_1	313:318	Mutation altering degron motif	0.7532
p.K324N	DO230529	LUSC	ICGC	LKPYVE	LIG_APCC_ABBA_1	313:318	Mutation substituting flanking lysine	0.2778
p.Q467H	DO26488	LUSC	ICGC	VLSTS	DEG_SPOP_SBC_1	475:479	Mutation blocking phosphorylation signal	0.5556
p.S736L	DO26444	LUSC	ICGC	MHGTPGHE	DEG_SCF_FBW7_2	736:743	Mutation altering degron motif	0.7667
p.P475L	DO27381	LUSC	ICGC	VLSTS	DEG_SPOP_SBC_1	475:479	Mutation altering degron motif	0.7582
p.P469S	DO222702	MELA	ICGC	VLSTS	DEG_SPOP_SBC_1	475:479	Mutation blocking phosphorylation signal	0.6111
p.R734W	DO46657	PAAD	ICGC	MHGTPGHE	DEG_SCF_FBW7_2	736:743	Mutation rewiring degron network	0.2778
p.T482M	DO51766	STAD	ICGC	VLSTS	DEG_SPOP_SBC_1	475:479	Mutation rewiring degron network	0.25
p.L21S	SIDM00683	Prostate Carcinoma	GDSC	ARTPLPTLN	DEG_APCC_DBOX_1	4:12	Mutation rewiring degron network	0.0833
p.L21S	ACH-000977	lymph node	CCLE	ARTPLPTLN	DEG_APCC_DBOX_1	4:12	Mutation rewiring degron network	0.0833
p.L21S	LNCaP-Clone-FGC	prostate	COSMIC	ARTPLPTLN	DEG_APCC_DBOX_1	4:12	Mutation rewiring degron network	0.0833
p.M732V	SIDM00933	Breast Carcinoma	GDSC	MHGTPGHE	DEG_SCF_FBW7_2	736:743	Mutation rewiring degron network	0.2222
p.M732V	CAL-51	breast	COSMIC	MHGTPGHE	DEG_SCF_FBW7_2	736:743	Mutation rewiring degron network	0.2222
p.N12K	SIDM00871	Non-Cancerous	GDSC	ARTPLPTLN	DEG_APCC_DBOX_1	4:12	Mutation altering degron motif	0.5806
p.N12K	SIDM00872	Breast Carcinoma	GDSC	ARTPLPTLN	DEG_APCC_DBOX_1	4:12	Mutation altering degron motif	0.5806
p.R3Q	ACH-000874	Leukemia	CCLE	ARTPLPTLN	DEG_APCC_DBOX_1	4:12	Mutation substituting flanking lysine	0.4167
p.R3Q	RS4-11	haematopoietic and lymphoid tissue	COSMIC	ARTPLPTLN	DEG_APCC_DBOX_1	4:12	Mutation substituting flanking lysine	0.4167
p.I2M	ACH-000992	Head and Neck Cancer	CCLE	ARTPLPTLN	DEG_APCC_DBOX_1	4:12	Mutation blocking phosphorylation signal	0.7222
p.I2M	Daudi	haematopoietic and lymphoid tissue	COSMIC	ARTPLPTLN	DEG_APCC_DBOX_1	4:12	Mutation blocking phosphorylation signal	0.7222
p.A484V	ACH-000994	Endometrial/Uterine Cancer	CCLE	VLSTS	DEG_SPOP_SBC_1	475:479	Mutation rewiring degron network	0.1944
p.R306P	ACH-002051	Lung Cancer	CCLE	LKPYVE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.1389
p.R306P	LU-134-A	lung	COSMIC	LKPYVE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.1389
p.R477W	MES-SA	soft tissue	COSMIC	VLSTS	DEG_SPOP_SBC_1	475:479	Mutation altering degron motif	0.8634
p.I2L	Daudi	haematopoietic and lymphoid tissue	COSMIC	ARTPLPTLN	DEG_APCC_DBOX_1	4:12	Mutation blocking phosphorylation signal	0.7222
p.R734Q	Jurkat	haematopoietic and lymphoid tissue	COSMIC	MHGTPGHE	DEG_SCF_FBW7_2	736:743	Mutation rewiring degron network	0.2778

Kaplan plot for MARK2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MARK2

UniProt ID: Q7KZI7

Entrez ID: 2011

Protein name: Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MARK2 in