DegronMD

Uniprot ID: Q7KZI7

Source protein: Serine/threonine-protein kinase MARK2

Source gene: MARK2

Class: DEG_APCC_DBOX_1

Location: 4:12

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9913

ASA_SCORE: 105.4

COIL: 0.9596

CONS_SCORE: 0.2511

DSS_SCORE: 0.8551

HELIX: 0.0278

FCONS_SCORE: 1.0276

RIG_SCORE: 0.6555

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L21F	TCGA-05-4396	LUAD	TCGA	ARTPLPTLN	DEG_APCC_DBOX_1	0.0833
p.L21F	DO23838	LUAD	ICGC	ARTPLPTLN	DEG_APCC_DBOX_1	0.0833
p.T16A	DO234463	ESAD	ICGC	ARTPLPTLN	DEG_APCC_DBOX_1	0.2222
p.R21L	DO229019	LICA	ICGC	ARTPLPTLN	DEG_APCC_DBOX_1	0.0833
p.L21S	SIDM00683	Prostate Carcinoma	GDSC	ARTPLPTLN	DEG_APCC_DBOX_1	0.0833
p.L21S	ACH-000977	lymph_node	CCLE	ARTPLPTLN	DEG_APCC_DBOX_1	0.0833
p.L21S	LNCaP-Clone-FGC	prostate	COSMIC	ARTPLPTLN	DEG_APCC_DBOX_1	0.0833
p.N12K	SIDM00871	Non-Cancerous	GDSC	ARTPLPTLN	DEG_APCC_DBOX_1	0.5806
p.N12K	SIDM00872	Breast Carcinoma	GDSC	ARTPLPTLN	DEG_APCC_DBOX_1	0.5806
p.R3Q	ACH-000874	Leukemia	CCLE	ARTPLPTLN	DEG_APCC_DBOX_1	0.4167
p.R3Q	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	ARTPLPTLN	DEG_APCC_DBOX_1	0.4167
p.I2M	ACH-000992	Head and Neck Cancer	CCLE	ARTPLPTLN	DEG_APCC_DBOX_1	0.7222
p.I2M	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ARTPLPTLN	DEG_APCC_DBOX_1	0.7222
p.I2L	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ARTPLPTLN	DEG_APCC_DBOX_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7KZI7	Serine/threonine-protein kinase MARK2	DEG_APCC_DBOX_1	4:12	ARTPLPTLN	APC,CDC20,FZR1	0.9913	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons