DegronMD

Uniprot ID: Q7KZI7

Source protein: Serine/threonine-protein kinase MARK2

Source gene: MARK2

Class: DEG_SCF_FBW7_2

Location: 736:743

E3 ligase: FBXW7

DEGRON score: 0.551

ASA_SCORE: 67.025

COIL: 0.6506

CONS_SCORE: 0.2951

DSS_SCORE: 0.1137

HELIX: 0.0271

FCONS_SCORE: 0.8866

RIG_SCORE: 0.7069

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E729Q	TCGA-ZJ-AAXT	CESC	TCGA	MHGTPGHE	DEG_SCF_FBW7_2	0.1389
p.S736L	DO26444	LUSC	ICGC	MHGTPGHE	DEG_SCF_FBW7_2	0.7667
p.R734W	DO46657	PAAD	ICGC	MHGTPGHE	DEG_SCF_FBW7_2	0.2778
p.M732V	SIDM00933	Breast Carcinoma	GDSC	MHGTPGHE	DEG_SCF_FBW7_2	0.2222
p.M732V	CAL-51	breast	COSMIC	MHGTPGHE	DEG_SCF_FBW7_2	0.2222
p.R734Q	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	MHGTPGHE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7KZI7	Serine/threonine-protein kinase MARK2	DEG_SCF_FBW7_2	736:743	MHGTPGHE	FBXW7	0.551	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons