DegronMD

Uniprot ID: Q7KZI7

Source protein: Serine/threonine-protein kinase MARK2

Source gene: MARK2

Class: LIG_APCC_ABBA_1

Location: 313:318

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9961

ASA_SCORE: 84.7667

COIL: 0.864

CONS_SCORE: 0.3638

DSS_SCORE: 0.4797

HELIX: 0.0275

FCONS_SCORE: 0.9918

RIG_SCORE: 0.7482

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P326L	TCGA-69-7979	LUAD	TCGA	LKPYVE	LIG_APCC_ABBA_1	0.1111
p.P326L	DO23874	LUAD	ICGC	LKPYVE	LIG_APCC_ABBA_1	0.1111
p.E309K	TCGA-AA-3833	COAD	TCGA	LKPYVE	LIG_APCC_ABBA_1	0.2222
p.E309K	TCGA-AP-A056	UCEC	TCGA	LKPYVE	LIG_APCC_ABBA_1	0.2222
p.R327Q	TCGA-BP-4961	KIRC	TCGA	LKPYVE	LIG_APCC_ABBA_1	0.0833
p.D325E	TCGA-XM-AAZ2	THYM	TCGA	LKPYVE	LIG_APCC_ABBA_1	0.1389
p.L328M	DO7776	COAD	ICGC	LKPYVE	LIG_APCC_ABBA_1	0.0556
p.E308D	DO8842	COAD	ICGC	LKPYVE	LIG_APCC_ABBA_1	0.1944
p.G315V	DO229028	LICA	ICGC	LKPYVE	LIG_APCC_ABBA_1	0.7532
p.K324N	DO230529	LUSC	ICGC	LKPYVE	LIG_APCC_ABBA_1	0.2778
p.R306P	ACH-002051	Lung Cancer	CCLE	LKPYVE	LIG_APCC_ABBA_1	0.1389
p.R306P	LU-134-A	lung	COSMIC	LKPYVE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7KZI7	Serine/threonine-protein kinase MARK2	LIG_APCC_ABBA_1	313:318	LKPYVE	APC,CDC20,FZR1	0.9961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons