DegronMD - Q9P275(USP36)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A998T	TCGA-19-5956	GBM	TCGA	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998T	SIDM00040	Gastric Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998T	TMK-1	stomach	COSMIC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.D985Y	TCGA-B5-A3FC	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.2222
p.L579I	TCGA-BR-8361	STAD	TCGA	VLSTS	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.6063
p.S991P	TCGA-BS-A0UJ	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	989:993	Mutation altering degron motif	0.6752
p.C994Y	TCGA-CG-5733	STAD	TCGA	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.3056
p.R572Q	DO3686	BRCA	ICGC	VLSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1667
p.R572Q	DO232224	PBCA	ICGC	VLSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1667
p.P583Q	DO20853	KIRP	ICGC	VLSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.3056
p.D590N	DO231819	LINC	ICGC	VLSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1111
p.V574A	DO229257	THCA	ICGC	VLSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.2222
p.D590Y	DO41871	UCEC	ICGC	VLSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1111
p.A998V	SIDM00582	Pancreatic Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998V	SIDM00437	Acute Myeloid Leukemia	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998V	SIDM00371	Pancreatic Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998V	SIDM00577	Neuroblastoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998V	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998V	SIDM00291	Melanoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998V	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998V	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998V	SIDM00589	Oral Cavity Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998V	SIDM00492	Glioblastoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998V	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998V	SIDM01146	Gastric Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998V	SIDM00561	Other Blood Cancers	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998V	SIDM00616	Hepatocellular Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998V	SIDM01257	Hepatocellular Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998V	SIDM00986	Head and Neck Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998V	SIDM00289	B-Lymphoblastic Leukemia	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998V	SIDM00503	Gastric Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998V	SIDM00603	Head and Neck Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998V	SIDM00381	Cervical Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998V	SIDM00062	Hepatocellular Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998V	SIDM00170	Head and Neck Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998V	SIDM00161	Biliary Tract Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998V	SIDM01691	Chronic Myelogenous Leukemia	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A998V	SIDM00164	Biliary Tract Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.A981T	SIDM00422	Hodgkin's Lymphoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1111
p.A981T	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1111
p.S992N	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation altering degron motif	0.7069
p.S992N	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation altering degron motif	0.7069
p.S992N	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation altering degron motif	0.7069
p.S992N	SIDM00650	Small Cell Lung Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation altering degron motif	0.7069
p.S992N	SIDM00854	Burkitt's Lymphoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation altering degron motif	0.7069
p.S992N	SIDM00849	Kidney Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation altering degron motif	0.7069
p.S992N	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation altering degron motif	0.7069
p.S992N	SIDM00907	Burkitt's Lymphoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation altering degron motif	0.7069
p.S992N	SIDM01147	Gastric Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation altering degron motif	0.7069
p.S992N	SIDM00863	Burkitt's Lymphoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation altering degron motif	0.7069
p.S992N	SIDM01681	Non-Cancerous	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation altering degron motif	0.7069
p.S992N	SIDM00479	Esophageal Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation altering degron motif	0.7069
p.S992N	SIDM00785	Acute Myeloid Leukemia	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation altering degron motif	0.7069
p.S992N	SIDM01409	Bladder Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	989:993	Mutation altering degron motif	0.7069
p.P1003H	ACH-000961	Endometrial/Uterine Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.0556
p.L585I	ACH-002287	Colon/Colorectal Cancer	CCLE	VLSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.25
p.L585I	NCI-H630	large intestine	COSMIC	VLSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.25

Kaplan plot for USP36 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP36

UniProt ID: Q9P275

Entrez ID: 57602

Protein name: Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP36 in