DegronMD - Q9UNZ2(NSFL1C)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L188I	TCGA-61-1725	OV	TCGA	SLDNGE	DEG_Kelch_Keap1_1	192:197	Mutation blocking ubiquitination signal	0.6667
p.A279V	TCGA-AX-A3G8	UCEC	TCGA	VLSTS	DEG_SPOP_SBC_1	267:271	Mutation rewiring degron network	0.1111
p.H183N	TCGA-BS-A0UV	UCEC	TCGA	SLDNGE	DEG_Kelch_Keap1_1	192:197	Mutation rewiring degron network	0.0833
p.D196G	TCGA-E7-A7DV	BLCA	TCGA	SLDNGE	DEG_Kelch_Keap1_1	192:197	Mutation altering degron motif	0.7198
p.A266D	TCGA-EO-A22U	UCEC	TCGA	VLSTS	DEG_SPOP_SBC_1	267:271	Mutation rewiring degron network	0.3056
p.S273R	TCGA-X6-A7WA	SARC	TCGA	VLSTS	DEG_SPOP_SBC_1	267:271	Mutation rewiring degron network	0.2778
p.V198G	DO48396	BLCA	ICGC	SLDNGE	DEG_Kelch_Keap1_1	192:197	Mutation rewiring degron network	0.3056
p.V198G	DO48363	BLCA	ICGC	SLDNGE	DEG_Kelch_Keap1_1	192:197	Mutation rewiring degron network	0.3056
p.H203R	DO9346	COAD	ICGC	SLDNGE	DEG_Kelch_Keap1_1	192:197	Mutation rewiring degron network	0.1667
p.R190W	DO8730	COAD	ICGC	SLDNGE	DEG_Kelch_Keap1_1	192:197	Mutation rewiring degron network	0.2778
p.R190W	DO222798	COCA	ICGC	SLDNGE	DEG_Kelch_Keap1_1	192:197	Mutation rewiring degron network	0.2778
p.R190W	DO13863	GBM	ICGC	SLDNGE	DEG_Kelch_Keap1_1	192:197	Mutation rewiring degron network	0.2778
p.R190W	DO14393	HNSC	ICGC	SLDNGE	DEG_Kelch_Keap1_1	192:197	Mutation rewiring degron network	0.2778
p.R190W	DO36881	READ	ICGC	SLDNGE	DEG_Kelch_Keap1_1	192:197	Mutation rewiring degron network	0.2778
p.R190W	DO43186	UCEC	ICGC	SLDNGE	DEG_Kelch_Keap1_1	192:197	Mutation rewiring degron network	0.2778
p.R190W	DO42400	UCEC	ICGC	SLDNGE	DEG_Kelch_Keap1_1	192:197	Mutation rewiring degron network	0.2778
p.R190W	DO41361	UCEC	ICGC	SLDNGE	DEG_Kelch_Keap1_1	192:197	Mutation rewiring degron network	0.2778
p.Q188K	DO228969	LICA	ICGC	SLDNGE	DEG_Kelch_Keap1_1	192:197	Mutation blocking ubiquitination signal	0.6667
p.R196K	DO228974	LICA	ICGC	SLDNGE	DEG_Kelch_Keap1_1	192:197	Mutation altering degron motif	0.7237
p.L197M	DO229031	LICA	ICGC	SLDNGE	DEG_Kelch_Keap1_1	192:197	Mutation altering degron motif	0.711
p.S204T	DO45527	LUSC	ICGC	SLDNGE	DEG_Kelch_Keap1_1	192:197	Mutation rewiring degron network	0.1389
p.R257L	DO37480	SKCM	ICGC	VLSTS	DEG_SPOP_SBC_1	267:271	Mutation rewiring degron network	0.0556
p.R257L	DO37443	SKCM	ICGC	VLSTS	DEG_SPOP_SBC_1	267:271	Mutation rewiring degron network	0.0556
p.R190Q	DO48016	STAD	ICGC	SLDNGE	DEG_Kelch_Keap1_1	192:197	Mutation rewiring degron network	0.2778
p.L270F	SIDM00664	Pancreatic Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	267:271	Mutation altering degron motif	0.6981
p.L270F	Hs766T	pancreas	COSMIC	VLSTS	DEG_SPOP_SBC_1	267:271	Mutation altering degron motif	0.6981
p.L186F	SIDM00025	Head and Neck Carcinoma	GDSC	SLDNGE	DEG_Kelch_Keap1_1	192:197	Mutation rewiring degron network	0.1667
p.L186F	UDSCC2	upper aerodigestive tract	COSMIC	SLDNGE	DEG_Kelch_Keap1_1	192:197	Mutation rewiring degron network	0.1667
p.S273I	SIDM01100	Neuroblastoma	GDSC	VLSTS	DEG_SPOP_SBC_1	267:271	Mutation rewiring degron network	0.2778
p.S273I	SK-N-DZ	autonomic ganglia	COSMIC	VLSTS	DEG_SPOP_SBC_1	267:271	Mutation rewiring degron network	0.2778
p.L268F	ACH-000178	Pancreatic Cancer	CCLE	VLSTS	DEG_SPOP_SBC_1	267:271	Mutation altering degron motif	0.587
p.L268F	Hs766T	pancreas	COSMIC	VLSTS	DEG_SPOP_SBC_1	267:271	Mutation altering degron motif	0.587
p.S271I	ACH-000366	Neuroblastoma	CCLE	VLSTS	DEG_SPOP_SBC_1	267:271	Mutation altering degron motif	0.7341
p.S271I	SK-N-DZ	autonomic ganglia	COSMIC	VLSTS	DEG_SPOP_SBC_1	267:271	Mutation altering degron motif	0.7341
p.L184F	ACH-002391	Head and Neck Cancer	CCLE	SLDNGE	DEG_Kelch_Keap1_1	192:197	Mutation rewiring degron network	0.1111
p.L184F	UDSCC2	upper aerodigestive tract	COSMIC	SLDNGE	DEG_Kelch_Keap1_1	192:197	Mutation rewiring degron network	0.1111
p.G274R	SW1271	lung	COSMIC	VLSTS	DEG_SPOP_SBC_1	267:271	Mutation rewiring degron network	0.25
p.T264I	HCT-15	large intestine	COSMIC	VLSTS	DEG_SPOP_SBC_1	267:271	Mutation rewiring degron network	0.25
p.R183C	COLO-205	large intestine	COSMIC	SLDNGE	DEG_Kelch_Keap1_1	192:197	Mutation rewiring degron network	0.0833
p.T264A	GP5d	large intestine	COSMIC	VLSTS	DEG_SPOP_SBC_1	267:271	Mutation rewiring degron network	0.25
p.I269S	HCC2998	large intestine	COSMIC	VLSTS	DEG_SPOP_SBC_1	267:271	Mutation altering degron motif	0.7341

Kaplan plot for NSFL1C in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NSFL1C

UniProt ID: Q9UNZ2

Entrez ID: 55968

Protein name: NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NSFL1C in