DegronMD

Uniprot ID: Q9UNZ2

Source protein: NSFL1 cofactor p47

Source gene: NSFL1C

Class: DEG_SPOP_SBC_1

Location: 267:271

E3 ligase: SPOP

DEGRON score: 0.7502

ASA_SCORE: 64.02

COIL: 0.655

CONS_SCORE: 0.2294

DSS_SCORE: 0.6111

HELIX: 0.1348

FCONS_SCORE: 0.3802

RIG_SCORE: 0.6907

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A279V	TCGA-AX-A3G8	UCEC	TCGA	VLSTS	DEG_SPOP_SBC_1	0.1111
p.A266D	TCGA-EO-A22U	UCEC	TCGA	VLSTS	DEG_SPOP_SBC_1	0.3056
p.S273R	TCGA-X6-A7WA	SARC	TCGA	VLSTS	DEG_SPOP_SBC_1	0.2778
p.R257L	DO37480	SKCM	ICGC	VLSTS	DEG_SPOP_SBC_1	0.0556
p.R257L	DO37443	SKCM	ICGC	VLSTS	DEG_SPOP_SBC_1	0.0556
p.L270F	SIDM00664	Pancreatic Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.6981
p.L270F	Hs766T	pancreas	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.6981
p.S273I	SIDM01100	Neuroblastoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.2778
p.S273I	SK-N-DZ	autonomic_ganglia	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.2778
p.L268F	ACH-000178	Pancreatic Cancer	CCLE	VLSTS	DEG_SPOP_SBC_1	0.587
p.L268F	Hs766T	pancreas	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.587
p.S271I	ACH-000366	Neuroblastoma	CCLE	VLSTS	DEG_SPOP_SBC_1	0.7341
p.S271I	SK-N-DZ	autonomic_ganglia	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.7341
p.G274R	SW1271	lung	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.25
p.T264I	HCT-15	large_intestine	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.25
p.T264A	GP5d	large_intestine	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.25
p.I269S	HCC2998	large_intestine	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.7341

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1481:1485	VLSTS	SPOP	0.7831	More...
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	334:338	VLSTS	SPOP	0.5966	More...
Q32MK0	Myosin light chain kinase 3	DEG_SPOP_SBC_1	174:178	VLSTS	SPOP	0.9947	More...
Q6IPM2	IQ domain-containing protein E	DEG_SPOP_SBC_1	318:322	VLSTS	SPOP	0.5759	More...
Q6ZMZ0	E3 ubiquitin-protein ligase RNF19B	DEG_SPOP_SBC_1	492:496	VLSTS	SPOP	0.944	More...
Q7KZI7	Serine/threonine-protein kinase MARK2	DEG_SPOP_SBC_1	475:479	VLSTS	SPOP	0.9918	More...
Q7Z460	CLIP-associating protein 1	DEG_SPOP_SBC_1	793:797	VLSTS	SPOP	0.9931	More...
Q8TEJ3	E3 ubiquitin-protein ligase SH3RF3	DEG_SPOP_SBC_1	696:700	VLSTS	SPOP	0.9715	More...
Q92540	Nonsense-mediated mRNA decay factor SMG7	DEG_SPOP_SBC_1	526:530	VLSTS	SPOP	0.9999	More...
Q96LA8	Protein arginine N-methyltransferase 6	DEG_SPOP_SBC_1	306:310	VLSTS	SPOP	0.5624	More...
Q9H0E7	Ubiquitin carboxyl-terminal hydrolase 44	DEG_SPOP_SBC_1	245:249	VLSTS	SPOP	0.9886	More...
Q9P275	Ubiquitin carboxyl-terminal hydrolase 36	DEG_SPOP_SBC_1	578:582	VLSTS	SPOP	0.9967	More...
Q9UNZ2	NSFL1 cofactor p47	DEG_SPOP_SBC_1	267:271	VLSTS	SPOP	0.7502	More...
Q5T8P6	RNA-binding protein 26	DEG_SPOP_SBC_1	687:691	VLSTS	SPOP	0.5563	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons