DegronMD - Q5T8P6(RBM26)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S390C	TCGA-53-7624	LUAD	TCGA	SATSSVPTV	DEG_COP1_1	398:406	Mutation rewiring degron network	0.1111
p.S390C	DO25058	LUAD	ICGC	SATSSVPTV	DEG_COP1_1	398:406	Mutation rewiring degron network	0.1111
p.S687Y	TCGA-55-8507	LUAD	TCGA	VLSTS	DEG_SPOP_SBC_1	687:691	Mutation altering degron motif	0.712
p.R139S	TCGA-5P-A9KA	KIRP	TCGA	PQSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1667
p.R139S	DO223953	KIRP	ICGC	PQSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1667
p.E96D	TCGA-AA-3815	COAD	TCGA	FFPHQE	LIG_APCC_ABBA_1	97:102	Mutation rewiring degron network	0.3056
p.E96D	DO9924	COAD	ICGC	FFPHQE	LIG_APCC_ABBA_1	97:102	Mutation rewiring degron network	0.3056
p.P639A	TCGA-AN-A0FL	BRCA	TCGA	VPSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.P639A	TCGA-E7-A3X6	BLCA	TCGA	VPSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.P639A	TCGA-GC-A3RD	BLCA	TCGA	VPSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.R456M	TCGA-AP-A1DK	UCEC	TCGA	QRPNLIGLT	DEG_APCC_DBOX_1	455:463	Mutation altering degron motif	0.8632
p.R456M	DO232224	PBCA	ICGC	QRPNLIGLT	DEG_APCC_DBOX_1	455:463	Mutation altering degron motif	0.8632
p.R456M	DO42033	UCEC	ICGC	QRPNLIGLT	DEG_APCC_DBOX_1	455:463	Mutation altering degron motif	0.8632
p.R472I	TCGA-B5-A11E	UCEC	TCGA	QRPNLIGLT	DEG_APCC_DBOX_1	455:463	Mutation rewiring degron network	0.0833
p.R472I	TCGA-EO-A22R	UCEC	TCGA	QRPNLIGLT	DEG_APCC_DBOX_1	455:463	Mutation rewiring degron network	0.0833
p.R472I	DO41644	UCEC	ICGC	QRPNLIGLT	DEG_APCC_DBOX_1	455:463	Mutation rewiring degron network	0.0833
p.R472I	DO42713	UCEC	ICGC	QRPNLIGLT	DEG_APCC_DBOX_1	455:463	Mutation rewiring degron network	0.0833
p.D104Y	TCGA-B5-A11N	UCEC	TCGA	FFPHQE	LIG_APCC_ABBA_1	97:102	Mutation rewiring degron network	0.2778
p.D104Y	DO41458	UCEC	ICGC	FFPHQE	LIG_APCC_ABBA_1	97:102	Mutation rewiring degron network	0.2778
p.V452M	TCGA-BS-A0UF	UCEC	TCGA	QRPNLIGLT	DEG_APCC_DBOX_1	455:463	Mutation rewiring degron network	0.25
p.V452M	DO41488	UCEC	ICGC	QRPNLIGLT	DEG_APCC_DBOX_1	455:463	Mutation rewiring degron network	0.25
p.P416S	TCGA-CQ-5326	HNSC	TCGA	SATSSVPTV	DEG_COP1_1	398:406	Mutation rewiring degron network	0.0556
p.P416S	DO15286	HNSC	ICGC	SATSSVPTV	DEG_COP1_1	398:406	Mutation rewiring degron network	0.0556
p.D104N	TCGA-CV-7568	HNSC	TCGA	FFPHQE	LIG_APCC_ABBA_1	97:102	Mutation rewiring degron network	0.2778
p.D104N	DO14160	HNSC	ICGC	FFPHQE	LIG_APCC_ABBA_1	97:102	Mutation rewiring degron network	0.2778
p.Q651K	TCGA-D3-A2JD	SKCM	TCGA	VPSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.D468N	TCGA-DF-A2KU	UCEC	TCGA	QRPNLIGLT	DEG_APCC_DBOX_1	455:463	Mutation rewiring degron network	0.1944
p.D468N	DO223286	UCEC	ICGC	QRPNLIGLT	DEG_APCC_DBOX_1	455:463	Mutation rewiring degron network	0.1944
p.R141C	TCGA-DK-A2HX	BLCA	TCGA	PQSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1111
p.R141C	DO473	BLCA	ICGC	PQSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1111
p.A696T	TCGA-EO-A22X	UCEC	TCGA	VLSTS	DEG_SPOP_SBC_1	687:691	Mutation substituting flanking lysine	0.3056
p.P396L	TCGA-GN-A26C	SKCM	TCGA	SATSSVPTV	DEG_COP1_1	398:406	Mutation rewiring degron network	0.2778
p.P396L	DO37782	SKCM	ICGC	SATSSVPTV	DEG_COP1_1	398:406	Mutation rewiring degron network	0.2778
p.P389L	TCGA-UU-A93S	BRCA	TCGA	SATSSVPTV	DEG_COP1_1	398:406	Mutation rewiring degron network	0.0833
p.P389L	DO219645	BRCA	ICGC	SATSSVPTV	DEG_COP1_1	398:406	Mutation rewiring degron network	0.0833
p.G91E	TCGA-YD-A89C	SKCM	TCGA	FFPHQE	LIG_APCC_ABBA_1	97:102	Mutation rewiring degron network	0.1667
p.G91E	DO219501	SKCM	ICGC	FFPHQE	LIG_APCC_ABBA_1	97:102	Mutation rewiring degron network	0.1667
p.P642A	DO475	BLCA	ICGC	VPSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.P642A	DO510	BLCA	ICGC	VPSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.P642A	DO1836	BRCA	ICGC	VPSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.A399S	DO225249	BRCA	ICGC	SATSSVPTV	DEG_COP1_1	398:406	Mutation altering degron motif	0.6477
p.S690F	DO233718	GACA	ICGC	VLSTS	DEG_SPOP_SBC_1	687:691	Mutation altering degron motif	0.7982
p.S635P	DO11358	GBM	ICGC	VPSST	DEG_SPOP_SBC_1	643:647	Mutation blocking phosphorylation signal	0.5556
p.S127C	DO228186	LICA	ICGC	PQSSS	DEG_SPOP_SBC_1	129:133	Mutation blocking phosphorylation signal	0.7222
p.S692Y	DO228944	LICA	ICGC	VLSTS	DEG_SPOP_SBC_1	687:691	Mutation rewiring degron network	0.3056
p.S402Y	DO228952	LICA	ICGC	SATSSVPTV	DEG_COP1_1	398:406	Mutation altering degron motif	0.6009
p.L462I	DO228976	LICA	ICGC	QRPNLIGLT	DEG_APCC_DBOX_1	455:463	Mutation altering degron motif	0.6063
p.A699E	DO229015	LICA	ICGC	VLSTS	DEG_SPOP_SBC_1	687:691	Mutation rewiring degron network	0.1111
p.A699E	DO229224	THCA	ICGC	VLSTS	DEG_SPOP_SBC_1	687:691	Mutation rewiring degron network	0.1111
p.L124V	DO23112	LINC	ICGC	PQSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1944
p.S690Y	DO45412	LUAD	ICGC	VLSTS	DEG_SPOP_SBC_1	687:691	Mutation altering degron motif	0.712
p.Q654K	DO37543	SKCM	ICGC	VPSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.1389
p.Q700K	DO229224	THCA	ICGC	VLSTS	DEG_SPOP_SBC_1	687:691	Mutation rewiring degron network	0.0833
p.A699T	DO43907	UCEC	ICGC	VLSTS	DEG_SPOP_SBC_1	687:691	Mutation rewiring degron network	0.1111
p.V700M	SIDM00120	Prostate Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	687:691	Mutation rewiring degron network	0.0833
p.V700M	DU-145	prostate	COSMIC	VLSTS	DEG_SPOP_SBC_1	687:691	Mutation rewiring degron network	0.0833
p.R141H	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PQSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1111
p.R141H	ACH-000953	Leukemia	CCLE	PQSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1111
p.R141H	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PQSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1111
p.E143K	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	PQSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.0556
p.E143K	ACH-002215	Lymphoma	CCLE	PQSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.0556
p.E143K	BC-3	haematopoietic and lymphoid tissue	COSMIC	PQSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.0556
p.P99A	SIDM00719	Small Cell Lung Carcinoma	GDSC	FFPHQE	LIG_APCC_ABBA_1	97:102	Mutation altering degron motif	0.7503
p.P99A	ACH-001364	Lung Cancer	CCLE	FFPHQE	LIG_APCC_ABBA_1	97:102	Mutation altering degron motif	0.7503
p.P99A	NCI-H345	lung	COSMIC	FFPHQE	LIG_APCC_ABBA_1	97:102	Mutation altering degron motif	0.7503
p.S449F	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	QRPNLIGLT	DEG_APCC_DBOX_1	455:463	Mutation rewiring degron network	0.1667
p.S449F	NCI-H1770	lung	COSMIC	QRPNLIGLT	DEG_APCC_DBOX_1	455:463	Mutation rewiring degron network	0.1667
p.S89L	ACH-000975	Lung Cancer	CCLE	FFPHQE	LIG_APCC_ABBA_1	97:102	Mutation rewiring degron network	0.1111
p.A648T	ACH-001369	Ovarian Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.S133P	ACH-001610	Brain Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.7863
p.P99L	ACH-001791	Liposarcoma	CCLE	FFPHQE	LIG_APCC_ABBA_1	97:102	Mutation altering degron motif	0.6471
p.E102D	ACH-002834	Bone Cancer	CCLE	FFPHQE	LIG_APCC_ABBA_1	97:102	Mutation altering degron motif	0.5647
p.V698M	DU-145	prostate	COSMIC	VLSTS	DEG_SPOP_SBC_1	687:691	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBM26

UniProt ID: Q5T8P6

Entrez ID: 64062

Protein name: RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for RBM26 in