DegronMD

Uniprot ID: Q5T8P6

Source protein: RNA-binding protein 26

Source gene: RBM26

Class: DEG_SPOP_SBC_1

Location: 643:647

E3 ligase: SPOP

DEGRON score: 0.9721

ASA_SCORE: 84.7

COIL: 0.9212

CONS_SCORE: 0.2072

DSS_SCORE: 0.5614

HELIX: 0.0422

FCONS_SCORE: 1.036

RIG_SCORE: 0.6476

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P639A	TCGA-AN-A0FL	BRCA	TCGA	VPSST	DEG_SPOP_SBC_1	0.2222
p.P639A	TCGA-E7-A3X6	BLCA	TCGA	VPSST	DEG_SPOP_SBC_1	0.2222
p.P639A	TCGA-GC-A3RD	BLCA	TCGA	VPSST	DEG_SPOP_SBC_1	0.2222
p.Q651K	TCGA-D3-A2JD	SKCM	TCGA	VPSST	DEG_SPOP_SBC_1	0.2222
p.P642A	DO475	BLCA	ICGC	VPSST	DEG_SPOP_SBC_1	0.3056
p.P642A	DO510	BLCA	ICGC	VPSST	DEG_SPOP_SBC_1	0.3056
p.P642A	DO1836	BRCA	ICGC	VPSST	DEG_SPOP_SBC_1	0.3056
p.S635P	DO11358	GBM	ICGC	VPSST	DEG_SPOP_SBC_1	0.5556
p.Q654K	DO37543	SKCM	ICGC	VPSST	DEG_SPOP_SBC_1	0.1389
p.A648T	ACH-001369	Ovarian Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43451	Maltase-glucoamylase	DEG_SPOP_SBC_1	1969:1973	VPSST	SPOP	0.5297	More...
O75509	Tumor necrosis factor receptor superfamily member 21	DEG_SPOP_SBC_1	241:245	VPSST	SPOP	0.9727	More...
P15941	Mucin-1	DEG_SPOP_SBC_1	45:49	VPSST	SPOP	0.9082	More...
P19438	Tumor necrosis factor receptor superfamily member 1A	DEG_SPOP_SBC_1	288:292	VPSST	SPOP	0.9514	More...
Q9H1K0	Rabenosyn-5	DEG_SPOP_SBC_1	580:584	VPSST	SPOP	0.9962	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	156:160	VPSST	SPOP	0.8129	More...
Q9H4W6	Transcription factor COE3	DEG_SPOP_SBC_1	473:477	VPSST	SPOP	0.9884	More...
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	DEG_SPOP_SBC_1	553:557	VPSST	SPOP	0.9515	More...
Q9NYB9	Abl interactor 2	DEG_SPOP_SBC_1	310:314	VPSST	SPOP	0.9925	More...
O14513	Nck-associated protein 5	DEG_SPOP_SBC_1	1773:1777	VPSST	SPOP	0.9973	More...
Q5T8P6	RNA-binding protein 26	DEG_SPOP_SBC_1	643:647	VPSST	SPOP	0.9721	More...
Q9NRJ5	Poly	DEG_SPOP_SBC_1	536:540	VPSST	SPOP	0.998	More...
Q6ZNC4	Zinc finger protein 704	DEG_SPOP_SBC_1	121:125	VPSST	SPOP	0.9625	More...
Q96LR7	Uncharacterized protein C2orf50	DEG_SPOP_SBC_1	119:123	VPSST	SPOP	0.8932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons