DegronMD

Uniprot ID: Q9H9J4

Source protein: Ubiquitin carboxyl-terminal hydrolase 42

Source gene: USP42

Class: DEG_SPOP_SBC_1

Location: 553:557

E3 ligase: SPOP

DEGRON score: 0.9515

ASA_SCORE: 88.82

COIL: 0.9336

CONS_SCORE: 0.2876

DSS_SCORE: 0.6246

HELIX: 0.046

FCONS_SCORE: 1.0331

RIG_SCORE: 0.636

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S543G	TCGA-CN-A63W	HNSC	TCGA	VPSST	DEG_SPOP_SBC_1	0.0556
p.S543G	DO49031	HNSC	ICGC	VPSST	DEG_SPOP_SBC_1	0.0556
p.S543I	TCGA-EY-A215	UCEC	TCGA	VPSST	DEG_SPOP_SBC_1	0.0556
p.S543I	DO42665	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	0.0556
p.V553I	TCGA-HU-8602	STAD	TCGA	VPSST	DEG_SPOP_SBC_1	0.7076
p.V553I	DO47829	STAD	ICGC	VPSST	DEG_SPOP_SBC_1	0.7076
p.V553I	SIDM01619	Endometrial Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.7076
p.V553I	ACH-000984	Endometrial/Uterine Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	0.7076
p.L546S	SIDM00792	Small Cell Lung Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.1389
p.L546S	NCI-H1688	lung	COSMIC	VPSST	DEG_SPOP_SBC_1	0.1389
p.I558V	SIDM01000	Melanoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.3056
p.I558V	ACH-000304	Skin Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	0.3056
p.I558V	WM-115	skin	COSMIC	VPSST	DEG_SPOP_SBC_1	0.3056
p.S556C	SIDM00863	Burkitt's Lymphoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.7541

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43451	Maltase-glucoamylase	DEG_SPOP_SBC_1	1969:1973	VPSST	SPOP	0.5297	More...
O75509	Tumor necrosis factor receptor superfamily member 21	DEG_SPOP_SBC_1	241:245	VPSST	SPOP	0.9727	More...
P15941	Mucin-1	DEG_SPOP_SBC_1	45:49	VPSST	SPOP	0.9082	More...
P19438	Tumor necrosis factor receptor superfamily member 1A	DEG_SPOP_SBC_1	288:292	VPSST	SPOP	0.9514	More...
Q9H1K0	Rabenosyn-5	DEG_SPOP_SBC_1	580:584	VPSST	SPOP	0.9962	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	156:160	VPSST	SPOP	0.8129	More...
Q9H4W6	Transcription factor COE3	DEG_SPOP_SBC_1	473:477	VPSST	SPOP	0.9884	More...
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	DEG_SPOP_SBC_1	553:557	VPSST	SPOP	0.9515	More...
Q9NYB9	Abl interactor 2	DEG_SPOP_SBC_1	310:314	VPSST	SPOP	0.9925	More...
O14513	Nck-associated protein 5	DEG_SPOP_SBC_1	1773:1777	VPSST	SPOP	0.9973	More...
Q5T8P6	RNA-binding protein 26	DEG_SPOP_SBC_1	643:647	VPSST	SPOP	0.9721	More...
Q9NRJ5	Poly	DEG_SPOP_SBC_1	536:540	VPSST	SPOP	0.998	More...
Q6ZNC4	Zinc finger protein 704	DEG_SPOP_SBC_1	121:125	VPSST	SPOP	0.9625	More...
Q96LR7	Uncharacterized protein C2orf50	DEG_SPOP_SBC_1	119:123	VPSST	SPOP	0.8932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons