DegronMD

Uniprot ID: O14513

Source protein: Nck-associated protein 5

Source gene: NCKAP5

Class: DEG_SPOP_SBC_1

Location: 1773:1777

E3 ligase: SPOP

DEGRON score: 0.9973

ASA_SCORE: 83.36

COIL: 0.9454

CONS_SCORE: 1

DSS_SCORE: 0.7292

HELIX: 0.0298

FCONS_SCORE: 1.6924

RIG_SCORE: 0.631

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1787T	TCGA-22-4613	LUSC	TCGA	VPSST	DEG_SPOP_SBC_1	0.0556
p.I1787T	DO26468	LUSC	ICGC	VPSST	DEG_SPOP_SBC_1	0.0556
p.L1769F	TCGA-3N-A9WC	SKCM	TCGA	VPSST	DEG_SPOP_SBC_1	0.2222
p.L1769F	DO51234	SKCM	ICGC	VPSST	DEG_SPOP_SBC_1	0.2222
p.M1764I	TCGA-55-1592	LUAD	TCGA	VPSST	DEG_SPOP_SBC_1	0.0833
p.M1764I	DO23556	LUAD	ICGC	VPSST	DEG_SPOP_SBC_1	0.0833
p.S1785R	TCGA-55-6972	LUAD	TCGA	VPSST	DEG_SPOP_SBC_1	0.1111
p.S1785R	DO25010	LUAD	ICGC	VPSST	DEG_SPOP_SBC_1	0.1111
p.D1784V	TCGA-90-7769	LUSC	TCGA	VPSST	DEG_SPOP_SBC_1	0.1389
p.D1784V	DO26822	LUSC	ICGC	VPSST	DEG_SPOP_SBC_1	0.1389
p.L1769R	TCGA-AA-3977	COAD	TCGA	VPSST	DEG_SPOP_SBC_1	0.2222
p.L1769R	DO8730	COAD	ICGC	VPSST	DEG_SPOP_SBC_1	0.2222
p.P1782R	TCGA-DU-6396	LGG	TCGA	VPSST	DEG_SPOP_SBC_1	0.1944
p.P1782R	DO22143	LGG	ICGC	VPSST	DEG_SPOP_SBC_1	0.1944
p.R1765G	TCGA-FI-A2D6	UCEC	TCGA	VPSST	DEG_SPOP_SBC_1	0.1111
p.R1765G	DO43867	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	0.1111
p.D1778A	TCGA-L5-A43J	ESCA	TCGA	VPSST	DEG_SPOP_SBC_1	0.3056
p.A1766V	TCGA-SW-A7EA	STAD	TCGA	VPSST	DEG_SPOP_SBC_1	0.1389
p.A1766V	DO51749	STAD	ICGC	VPSST	DEG_SPOP_SBC_1	0.1389
p.R1771C	DO233270	GACA	ICGC	VPSST	DEG_SPOP_SBC_1	0.2778
p.R1771H	DO228138	PBCA	ICGC	VPSST	DEG_SPOP_SBC_1	0.2778
p.M1764V	DO50432	PRAD	ICGC	VPSST	DEG_SPOP_SBC_1	0.0833
p.A1783E	DO50415	PRAD	ICGC	VPSST	DEG_SPOP_SBC_1	0.1667
p.S1763Y	DO46941	RECA	ICGC	VPSST	DEG_SPOP_SBC_1	0.0556
p.A1766T	DO46941	RECA	ICGC	VPSST	DEG_SPOP_SBC_1	0.1389
p.G1779S	SIDM01295	Pancreatic Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.2778
p.R1781H	SIDM00596	Endometrial Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.2222
p.R1781H	SIDM00487	Colorectal Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.2222
p.R1781H	ACH-000941	Endometrial/Uterine Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	0.2222
p.R1781H	ACH-000954	Endometrial/Uterine Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	0.2222
p.R1781H	ACH-000963	Colon/Colorectal Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	0.2222
p.R1781H	ACH-001517	Endometrial/Uterine Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	0.2222
p.R1781H	ACH-001991	Primary	CCLE	VPSST	DEG_SPOP_SBC_1	0.2222
p.R1781H	CCK-81	large_intestine	COSMIC	VPSST	DEG_SPOP_SBC_1	0.2222
p.R1781H	HEC-1	endometrium	COSMIC	VPSST	DEG_SPOP_SBC_1	0.2222
p.S1763F	ACH-001568	Skin Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43451	Maltase-glucoamylase	DEG_SPOP_SBC_1	1969:1973	VPSST	SPOP	0.5297	More...
O75509	Tumor necrosis factor receptor superfamily member 21	DEG_SPOP_SBC_1	241:245	VPSST	SPOP	0.9727	More...
P15941	Mucin-1	DEG_SPOP_SBC_1	45:49	VPSST	SPOP	0.9082	More...
P19438	Tumor necrosis factor receptor superfamily member 1A	DEG_SPOP_SBC_1	288:292	VPSST	SPOP	0.9514	More...
Q9H1K0	Rabenosyn-5	DEG_SPOP_SBC_1	580:584	VPSST	SPOP	0.9962	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	156:160	VPSST	SPOP	0.8129	More...
Q9H4W6	Transcription factor COE3	DEG_SPOP_SBC_1	473:477	VPSST	SPOP	0.9884	More...
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	DEG_SPOP_SBC_1	553:557	VPSST	SPOP	0.9515	More...
Q9NYB9	Abl interactor 2	DEG_SPOP_SBC_1	310:314	VPSST	SPOP	0.9925	More...
O14513	Nck-associated protein 5	DEG_SPOP_SBC_1	1773:1777	VPSST	SPOP	0.9973	More...
Q5T8P6	RNA-binding protein 26	DEG_SPOP_SBC_1	643:647	VPSST	SPOP	0.9721	More...
Q9NRJ5	Poly	DEG_SPOP_SBC_1	536:540	VPSST	SPOP	0.998	More...
Q6ZNC4	Zinc finger protein 704	DEG_SPOP_SBC_1	121:125	VPSST	SPOP	0.9625	More...
Q96LR7	Uncharacterized protein C2orf50	DEG_SPOP_SBC_1	119:123	VPSST	SPOP	0.8932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPSST

Degron related mutations and impact score

Drug responses associated with NCKAP5 mutations

All proteins holding degron of VPSST