DegronMD - Q9H4W6(EBF3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q470K	TCGA-55-8507	LUAD	TCGA	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation rewiring degron network	0.2222
p.Q470K	TCGA-55-8507	LUAD	TCGA	VPSST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.25
p.A488T	TCGA-A5-A0G2	UCEC	TCGA	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation rewiring degron network	0.1389
p.A488T	TCGA-BR-7704	STAD	TCGA	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation rewiring degron network	0.1389
p.A488T	TCGA-FG-A6J1	LGG	TCGA	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation rewiring degron network	0.1389
p.A490V	TCGA-AA-3864	COAD	TCGA	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation rewiring degron network	0.0833
p.N473S	TCGA-CD-A4MJ	STAD	TCGA	VPSST	DEG_SPOP_SBC_1	473:477	Mutation altering degron motif	0.7069
p.V464I	TCGA-D1-A103	UCEC	TCGA	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation rewiring degron network	0.0556
p.V464I	TCGA-D1-A103	UCEC	TCGA	VPSST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.0833
p.V464I	TCGA-IN-A6RI	STAD	TCGA	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation rewiring degron network	0.0556
p.V464I	TCGA-IN-A6RI	STAD	TCGA	VPSST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.0833
p.P469L	TCGA-DX-A8BP	SARC	TCGA	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation rewiring degron network	0.1944
p.P469L	TCGA-DX-A8BP	SARC	TCGA	VPSST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.2222
p.S491I	TCGA-G4-6628	COAD	TCGA	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation rewiring degron network	0.0556
p.R470Q	DO51612	CESC	ICGC	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation rewiring degron network	0.2222
p.R470Q	DO51612	CESC	ICGC	VPSST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.25
p.T488N	DO229029	LICA	ICGC	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation rewiring degron network	0.1389
p.T485K	DO229008	LICA	ICGC	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation rewiring degron network	0.2222
p.T485K	DO229008	LICA	ICGC	VPSST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.1111
p.Q479K	DO45412	LUAD	ICGC	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation altering degron motif	0.5833
p.V467L	DO24760	LUAD	ICGC	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation rewiring degron network	0.1389
p.V467L	DO24760	LUAD	ICGC	VPSST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.1667
p.T477A	DO232007	ORCA	ICGC	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation altering degron motif	0.7139
p.T477A	DO232007	ORCA	ICGC	VPSST	DEG_SPOP_SBC_1	473:477	Mutation altering degron motif	0.7139
p.V473I	DO34905	PACA	ICGC	VPSST	DEG_SPOP_SBC_1	473:477	Mutation altering degron motif	0.7076
p.V473I	DO51736	STAD	ICGC	VPSST	DEG_SPOP_SBC_1	473:477	Mutation altering degron motif	0.7076
p.V473I	DO42312	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	473:477	Mutation altering degron motif	0.7076
p.S475I	DO231284	PACA	ICGC	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation altering degron motif	0.623
p.S475I	DO231284	PACA	ICGC	VPSST	DEG_SPOP_SBC_1	473:477	Mutation altering degron motif	0.7341
p.P478L	DO220056	SARC	ICGC	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation altering degron motif	0.7582
p.N463T	DO37810	SKCM	ICGC	VPSST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.0556
p.N463K	DO37810	SKCM	ICGC	VPSST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.0556
p.N482S	DO47811	STAD	ICGC	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation rewiring degron network	0.3056
p.N482S	DO47811	STAD	ICGC	VPSST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.1944
p.S491N	SIDM00845	Burkitt's Lymphoma	GDSC	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation rewiring degron network	0.0556
p.S491N	SIDM00461	Acute Myeloid Leukemia	GDSC	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation rewiring degron network	0.0556
p.S491N	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation rewiring degron network	0.0556
p.S491N	SIDM01519	Head and Neck Carcinoma	GDSC	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation rewiring degron network	0.0556
p.S491N	Daudi	haematopoietic and lymphoid tissue	COSMIC	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation rewiring degron network	0.0556
p.S491N	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation rewiring degron network	0.0556
p.S491N	DND-41	haematopoietic and lymphoid tissue	COSMIC	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation rewiring degron network	0.0556
p.M481I	SIDM00011	Melanoma	GDSC	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation altering degron motif	0.7618
p.M490I	ACH-000477	Skin Cancer	CCLE	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation rewiring degron network	0.0833
p.S465N	ACH-000919	Gastric Cancer	CCLE	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation rewiring degron network	0.0833
p.S465N	ACH-000919	Gastric Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.1111
p.S465N	IM-95	stomach	COSMIC	PSSTPQQS	DEG_SCF_FBW7_1	474:481	Mutation rewiring degron network	0.0833
p.S465N	IM-95	stomach	COSMIC	VPSST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EBF3

UniProt ID: Q9H4W6

Entrez ID: 253738

Protein name: Transcription factor COE3 (Early B-cell factor 3) (EBF-3) (Olf-1/EBF-like 2) (O/E-2) (OE-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EBF3 in