DegronMD

Uniprot ID: Q9H4W6

Source protein: Transcription factor COE3

Source gene: EBF3

Class: DEG_SPOP_SBC_1

Location: 473:477

E3 ligase: SPOP

DEGRON score: 0.9884

ASA_SCORE: 67.66

COIL: 0.8828

CONS_SCORE: 0.328

DSS_SCORE: 0.6061

HELIX: 0.0228

FCONS_SCORE: 0.9951

RIG_SCORE: 0.6374

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q470K	TCGA-55-8507	LUAD	TCGA	VPSST	DEG_SPOP_SBC_1	0.25
p.N473S	TCGA-CD-A4MJ	STAD	TCGA	VPSST	DEG_SPOP_SBC_1	0.7069
p.V464I	TCGA-D1-A103	UCEC	TCGA	VPSST	DEG_SPOP_SBC_1	0.0833
p.V464I	TCGA-IN-A6RI	STAD	TCGA	VPSST	DEG_SPOP_SBC_1	0.0833
p.P469L	TCGA-DX-A8BP	SARC	TCGA	VPSST	DEG_SPOP_SBC_1	0.2222
p.R470Q	DO51612	CESC	ICGC	VPSST	DEG_SPOP_SBC_1	0.25
p.T485K	DO229008	LICA	ICGC	VPSST	DEG_SPOP_SBC_1	0.1111
p.V467L	DO24760	LUAD	ICGC	VPSST	DEG_SPOP_SBC_1	0.1667
p.T477A	DO232007	ORCA	ICGC	VPSST	DEG_SPOP_SBC_1	0.7139
p.V473I	DO34905	PACA	ICGC	VPSST	DEG_SPOP_SBC_1	0.7076
p.V473I	DO51736	STAD	ICGC	VPSST	DEG_SPOP_SBC_1	0.7076
p.V473I	DO42312	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	0.7076
p.S475I	DO231284	PACA	ICGC	VPSST	DEG_SPOP_SBC_1	0.7341
p.N463T	DO37810	SKCM	ICGC	VPSST	DEG_SPOP_SBC_1	0.0556
p.N463K	DO37810	SKCM	ICGC	VPSST	DEG_SPOP_SBC_1	0.0556
p.N482S	DO47811	STAD	ICGC	VPSST	DEG_SPOP_SBC_1	0.1944
p.S465N	ACH-000919	Gastric Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	0.1111
p.S465N	IM-95	stomach	COSMIC	VPSST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43451	Maltase-glucoamylase	DEG_SPOP_SBC_1	1969:1973	VPSST	SPOP	0.5297	More...
O75509	Tumor necrosis factor receptor superfamily member 21	DEG_SPOP_SBC_1	241:245	VPSST	SPOP	0.9727	More...
P15941	Mucin-1	DEG_SPOP_SBC_1	45:49	VPSST	SPOP	0.9082	More...
P19438	Tumor necrosis factor receptor superfamily member 1A	DEG_SPOP_SBC_1	288:292	VPSST	SPOP	0.9514	More...
Q9H1K0	Rabenosyn-5	DEG_SPOP_SBC_1	580:584	VPSST	SPOP	0.9962	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	156:160	VPSST	SPOP	0.8129	More...
Q9H4W6	Transcription factor COE3	DEG_SPOP_SBC_1	473:477	VPSST	SPOP	0.9884	More...
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	DEG_SPOP_SBC_1	553:557	VPSST	SPOP	0.9515	More...
Q9NYB9	Abl interactor 2	DEG_SPOP_SBC_1	310:314	VPSST	SPOP	0.9925	More...
O14513	Nck-associated protein 5	DEG_SPOP_SBC_1	1773:1777	VPSST	SPOP	0.9973	More...
Q5T8P6	RNA-binding protein 26	DEG_SPOP_SBC_1	643:647	VPSST	SPOP	0.9721	More...
Q9NRJ5	Poly	DEG_SPOP_SBC_1	536:540	VPSST	SPOP	0.998	More...
Q6ZNC4	Zinc finger protein 704	DEG_SPOP_SBC_1	121:125	VPSST	SPOP	0.9625	More...
Q96LR7	Uncharacterized protein C2orf50	DEG_SPOP_SBC_1	119:123	VPSST	SPOP	0.8932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons