DegronMD - O14513(NCKAP5)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S895L	TCGA-12-0616	GBM	TCGA	SSDSGE	DEG_Kelch_Keap1_1	903:908	Mutation rewiring degron network	0.1111
p.S895L	TCGA-12-0616	GBM	TCGA	DSGEPPT	DEG_SCF_TRCP1_1	905:911	Mutation rewiring degron network	0.0556
p.S895L	DO12718	GBM	ICGC	SSDSGE	DEG_Kelch_Keap1_1	903:908	Mutation rewiring degron network	0.1111
p.S895L	DO12718	GBM	ICGC	DSGEPPT	DEG_SCF_TRCP1_1	905:911	Mutation rewiring degron network	0.0556
p.I1787T	TCGA-22-4613	LUSC	TCGA	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.0556
p.I1787T	TCGA-22-4613	LUSC	TCGA	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.3056
p.I1787T	DO26468	LUSC	ICGC	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.0556
p.I1787T	DO26468	LUSC	ICGC	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.3056
p.V1015A	TCGA-24-2281	OV	TCGA	APSSS	DEG_SPOP_SBC_1	1024:1028	Mutation rewiring degron network	0.0833
p.V1015A	TCGA-BR-8060	STAD	TCGA	APSSS	DEG_SPOP_SBC_1	1024:1028	Mutation rewiring degron network	0.0833
p.V1015A	DO32459	OV	ICGC	APSSS	DEG_SPOP_SBC_1	1024:1028	Mutation rewiring degron network	0.0833
p.V1015A	DO38205	STAD	ICGC	APSSS	DEG_SPOP_SBC_1	1024:1028	Mutation rewiring degron network	0.0833
p.Q1300E	TCGA-33-AAS8	LUSC	TCGA	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation rewiring degron network	0.1111
p.Q1300E	DO219123	LUSC	ICGC	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation rewiring degron network	0.1111
p.M1715L	TCGA-3H-AB3S	MESO	TCGA	DSGIGT	DEG_SCF_TRCP1_1	1719:1724	Mutation rewiring degron network	0.2222
p.L1769F	TCGA-3N-A9WC	SKCM	TCGA	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.2222
p.L1769F	DO51234	SKCM	ICGC	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.2222
p.Q1064R	TCGA-43-A56U	LUSC	TCGA	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation altering degron motif	0.6218
p.Q1064R	DO49083	LUSC	ICGC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation altering degron motif	0.6218
p.L1076M	TCGA-50-5933	LUAD	TCGA	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.1389
p.L1076M	DO24800	LUAD	ICGC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.1389
p.M1764I	TCGA-55-1592	LUAD	TCGA	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.0833
p.M1764I	DO23556	LUAD	ICGC	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.0833
p.S1785R	TCGA-55-6972	LUAD	TCGA	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.1111
p.S1785R	TCGA-55-6972	LUAD	TCGA	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.25
p.S1785R	DO25010	LUAD	ICGC	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.1111
p.S1785R	DO25010	LUAD	ICGC	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.25
p.D905N	TCGA-55-7726	LUAD	TCGA	SSDSGE	DEG_Kelch_Keap1_1	903:908	Mutation altering degron motif	0.6932
p.D905N	TCGA-55-7726	LUAD	TCGA	DSGEPPT	DEG_SCF_TRCP1_1	905:911	Mutation altering degron motif	0.6932
p.D905N	DO25594	LUAD	ICGC	SSDSGE	DEG_Kelch_Keap1_1	903:908	Mutation altering degron motif	0.6932
p.D905N	DO25594	LUAD	ICGC	DSGEPPT	DEG_SCF_TRCP1_1	905:911	Mutation altering degron motif	0.6932
p.E1109D	TCGA-61-2002	OV	TCGA	VSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.1667
p.E1109D	DO27994	OV	ICGC	VSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.1667
p.G1062V	TCGA-64-5781	LUAD	TCGA	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.3056
p.G1062V	DO23740	LUAD	ICGC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.3056
p.T1079M	TCGA-77-7337	LUSC	TCGA	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.0556
p.T1079M	TCGA-DU-6392	LGG	TCGA	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.0556
p.T1079M	TCGA-WS-AB45	COAD	TCGA	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.0556
p.T1079M	DO51734	COAD	ICGC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.0556
p.T1079M	DO222881	COCA	ICGC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.0556
p.T1079M	DO22237	LGG	ICGC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.0556
p.T1079M	DO27445	LUSC	ICGC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.0556
p.E1109Q	TCGA-80-5607	LUAD	TCGA	VSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.1667
p.E1109Q	DO25957	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.1667
p.D1784V	TCGA-90-7769	LUSC	TCGA	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.1389
p.D1784V	TCGA-90-7769	LUSC	TCGA	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.2222
p.D1784V	DO26822	LUSC	ICGC	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.1389
p.D1784V	DO26822	LUSC	ICGC	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.2222
p.S1118F	TCGA-A5-A0G2	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.7982
p.S1118F	DO41235	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.7982
p.H1789Q	TCGA-A5-A1OF	UCEC	TCGA	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation altering degron motif	0.647
p.H1789Q	DO42568	UCEC	ICGC	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation altering degron motif	0.647
p.H1276D	TCGA-A7-A6VY	BRCA	TCGA	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation rewiring degron network	0.0556
p.H1276D	DO50021	BRCA	ICGC	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation rewiring degron network	0.0556
p.T1288M	TCGA-AA-3681	COAD	TCGA	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation altering degron motif	0.7423
p.T1288M	DO9682	COAD	ICGC	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation altering degron motif	0.7423
p.T1288M	DO233072	GACA	ICGC	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation altering degron motif	0.7423
p.T1288M	SIDM01293	Colorectal Carcinoma	GDSC	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation altering degron motif	0.7423
p.L1769R	TCGA-AA-3977	COAD	TCGA	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.2222
p.L1769R	DO8730	COAD	ICGC	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.2222
p.D1284Y	TCGA-AA-3977	COAD	TCGA	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation rewiring degron network	0.2778
p.D1284Y	DO8730	COAD	ICGC	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation rewiring degron network	0.2778
p.M1032L	TCGA-AA-A02R	COAD	TCGA	APSSS	DEG_SPOP_SBC_1	1024:1028	Mutation rewiring degron network	0.2222
p.L1076P	TCGA-AG-3906	READ	TCGA	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.1389
p.L1076P	DO36491	READ	ICGC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.1389
p.S1734L	TCGA-AP-A0LM	UCEC	TCGA	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation altering degron motif	0.6556
p.S1734L	DO43306	UCEC	ICGC	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation altering degron motif	0.6556
p.S1123P	TCGA-AX-A063	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.2222
p.S1123P	DO42201	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.2222
p.R1733H	TCGA-AX-A1CE	UCEC	TCGA	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation altering degron motif	0.7133
p.R1733H	TCGA-BR-7851	STAD	TCGA	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation altering degron motif	0.7133
p.R1733H	TCGA-RQ-A68N	DLBC	TCGA	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation altering degron motif	0.7133
p.R1733H	DO219921	DLBC	ICGC	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation altering degron motif	0.7133
p.R1733H	DO38711	STAD	ICGC	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation altering degron motif	0.7133
p.R1733H	DO42280	UCEC	ICGC	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation altering degron motif	0.7133
p.A900V	TCGA-AZ-4614	COAD	TCGA	SSDSGE	DEG_Kelch_Keap1_1	903:908	Mutation rewiring degron network	0.25
p.A900V	TCGA-AZ-4614	COAD	TCGA	DSGEPPT	DEG_SCF_TRCP1_1	905:911	Mutation rewiring degron network	0.1944
p.A900V	DO10012	COAD	ICGC	SSDSGE	DEG_Kelch_Keap1_1	903:908	Mutation rewiring degron network	0.25
p.A900V	DO10012	COAD	ICGC	DSGEPPT	DEG_SCF_TRCP1_1	905:911	Mutation rewiring degron network	0.1944
p.A900V	DO228581	GACA	ICGC	SSDSGE	DEG_Kelch_Keap1_1	903:908	Mutation rewiring degron network	0.25
p.A900V	DO228581	GACA	ICGC	DSGEPPT	DEG_SCF_TRCP1_1	905:911	Mutation rewiring degron network	0.1944
p.A1125T	TCGA-AZ-6599	COAD	TCGA	VSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.1667
p.A1125T	DO10606	COAD	ICGC	VSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.1667
p.A1022D	TCGA-B5-A0JY	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	1024:1028	Mutation rewiring degron network	0.2778
p.A1022D	DO43041	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	1024:1028	Mutation rewiring degron network	0.2778
p.R1298C	TCGA-BP-5177	KIRC	TCGA	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation rewiring degron network	0.1667
p.R1298C	DO16614	KIRC	ICGC	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation rewiring degron network	0.1667
p.A1125S	TCGA-BP-5190	KIRC	TCGA	VSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.1667
p.A1125S	DO17937	KIRC	ICGC	VSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.1667
p.T1056S	TCGA-BS-A0WQ	UCEC	TCGA	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.1389
p.T1056S	DO42705	UCEC	ICGC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.1389
p.S1730L	TCGA-CA-6717	COAD	TCGA	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation altering degron motif	0.7667
p.S1730L	DO8264	COAD	ICGC	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation altering degron motif	0.7667
p.R1737C	TCGA-CV-A463	HNSC	TCGA	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation rewiring degron network	0.2778
p.R1737C	DO10324	COAD	ICGC	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation rewiring degron network	0.2778
p.R1737C	DO233687	GACA	ICGC	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation rewiring degron network	0.2778
p.R1737C	DO52066	HNSC	ICGC	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation rewiring degron network	0.2778
p.G894V	TCGA-D3-A3CE	SKCM	TCGA	SSDSGE	DEG_Kelch_Keap1_1	903:908	Mutation rewiring degron network	0.0833
p.G894V	DO37405	SKCM	ICGC	SSDSGE	DEG_Kelch_Keap1_1	903:908	Mutation rewiring degron network	0.0833
p.P1036S	TCGA-D3-A8GM	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	1024:1028	Mutation rewiring degron network	0.1111
p.P1036S	DO50288	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	1024:1028	Mutation rewiring degron network	0.1111
p.T1724P	TCGA-D7-6528	STAD	TCGA	DSGIGT	DEG_SCF_TRCP1_1	1719:1724	Mutation altering degron motif	0.7031
p.T1724P	DO38547	STAD	ICGC	DSGIGT	DEG_SCF_TRCP1_1	1719:1724	Mutation altering degron motif	0.7031
p.V1297A	TCGA-D8-A27H	BRCA	TCGA	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation rewiring degron network	0.1944
p.V1297A	DO1249	BRCA	ICGC	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation rewiring degron network	0.1944
p.M1078I	TCGA-DA-A1HY	SKCM	TCGA	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.0833
p.M1078I	DO37409	SKCM	ICGC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.0833
p.M1801I	TCGA-DA-A960	SKCM	TCGA	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.0833
p.M1801I	DO219482	SKCM	ICGC	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.0833
p.V1115I	TCGA-DF-A2KZ	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.7076
p.V1115I	DO52409	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.7076
p.P1782R	TCGA-DU-6396	LGG	TCGA	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.1944
p.P1782R	TCGA-DU-6396	LGG	TCGA	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.1667
p.P1782R	DO22143	LGG	ICGC	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.1944
p.P1782R	DO22143	LGG	ICGC	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.1667
p.S1119T	TCGA-E6-A1LX	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.6005
p.S1119T	DO41020	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.6005
p.P1742A	TCGA-E7-A4IJ	BLCA	TCGA	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation rewiring degron network	0.1389
p.P1742A	DO453	BLCA	ICGC	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation rewiring degron network	0.1389
p.A1125V	TCGA-E9-A1RH	BRCA	TCGA	VSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.1667
p.A1125V	DO1279	BRCA	ICGC	VSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.1667
p.E957K	TCGA-EB-A97M	SKCM	TCGA	APSST	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.25
p.E957K	TCGA-EE-A182	SKCM	TCGA	APSST	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.25
p.E957K	DO37814	SKCM	ICGC	APSST	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.25
p.E957K	DO50298	SKCM	ICGC	APSST	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.25
p.R1765G	TCGA-FI-A2D6	UCEC	TCGA	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.1111
p.R1765G	DO43867	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.1111
p.P1794S	TCGA-FR-A726	SKCM	TCGA	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.2778
p.P1794S	DO48665	SKCM	ICGC	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.2778
p.G1731E	TCGA-FR-A726	SKCM	TCGA	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation altering degron motif	0.7199
p.G1731E	DO48665	SKCM	ICGC	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation altering degron motif	0.7199
p.E1077K	TCGA-FR-A726	SKCM	TCGA	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.1111
p.E1077K	DO48665	SKCM	ICGC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.1111
p.D1060N	TCGA-FR-A726	SKCM	TCGA	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.25
p.D1060N	DO48665	SKCM	ICGC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.25
p.E1710K	TCGA-FS-A1ZA	SKCM	TCGA	DSGIGT	DEG_SCF_TRCP1_1	1719:1724	Mutation rewiring degron network	0.0833
p.E1710K	DO37551	SKCM	ICGC	DSGIGT	DEG_SCF_TRCP1_1	1719:1724	Mutation rewiring degron network	0.0833
p.R1802K	TCGA-FW-A3R5	SKCM	TCGA	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.0556
p.R1802K	DO37406	SKCM	ICGC	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.0556
p.R1802K	SIDM00007	Other Solid Cancers	GDSC	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.0556
p.R1802K	ACH-001550	Skin Cancer	CCLE	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.0556
p.R1802K	MCC13	skin	COSMIC	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.0556
p.E902K	TCGA-FW-A3R5	SKCM	TCGA	SSDSGE	DEG_Kelch_Keap1_1	903:908	Mutation rewiring degron network	0.3056
p.E902K	TCGA-FW-A3R5	SKCM	TCGA	DSGEPPT	DEG_SCF_TRCP1_1	905:911	Mutation rewiring degron network	0.25
p.E902K	DO37406	SKCM	ICGC	SSDSGE	DEG_Kelch_Keap1_1	903:908	Mutation rewiring degron network	0.3056
p.E902K	DO37406	SKCM	ICGC	DSGEPPT	DEG_SCF_TRCP1_1	905:911	Mutation rewiring degron network	0.25
p.S953F	TCGA-GN-A8LK	SKCM	TCGA	APSST	DEG_SPOP_SBC_1	950:954	Mutation altering degron motif	0.7982
p.S953F	DO51259	SKCM	ICGC	APSST	DEG_SPOP_SBC_1	950:954	Mutation altering degron motif	0.7982
p.D1778A	TCGA-L5-A43J	ESCA	TCGA	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.3056
p.D1778A	TCGA-L5-A43J	ESCA	TCGA	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.0556
p.R1298H	TCGA-L5-A43J	ESCA	TCGA	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation rewiring degron network	0.1667
p.R1298H	SIDM01608	Endometrial Carcinoma	GDSC	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation rewiring degron network	0.1667
p.R1298H	ACH-000990	Endometrial/Uterine Cancer	CCLE	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation rewiring degron network	0.1667
p.P909T	TCGA-L9-A444	LUAD	TCGA	DSGEPPT	DEG_SCF_TRCP1_1	905:911	Mutation altering degron motif	0.5919
p.P909T	DO234273	ESAD	ICGC	DSGEPPT	DEG_SCF_TRCP1_1	905:911	Mutation altering degron motif	0.5919
p.P909T	DO26015	LUAD	ICGC	DSGEPPT	DEG_SCF_TRCP1_1	905:911	Mutation altering degron motif	0.5919
p.P1728L	TCGA-MP-A4TC	LUAD	TCGA	DSGIGT	DEG_SCF_TRCP1_1	1719:1724	Mutation rewiring degron network	0.2222
p.P1728L	TCGA-MP-A4TC	LUAD	TCGA	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation rewiring degron network	0.3056
p.P1728L	DO45342	LUAD	ICGC	DSGIGT	DEG_SCF_TRCP1_1	1719:1724	Mutation rewiring degron network	0.2222
p.P1728L	DO45342	LUAD	ICGC	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation rewiring degron network	0.3056
p.P1742Q	TCGA-NI-A4U2	LIHC	TCGA	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation rewiring degron network	0.1389
p.P1742Q	DO48589	LIHC	ICGC	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation rewiring degron network	0.1389
p.A1766V	TCGA-SW-A7EA	STAD	TCGA	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.1389
p.A1766V	DO51749	STAD	ICGC	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.1389
p.E1074K	TCGA-XX-A899	BRCA	TCGA	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.1944
p.E1074K	DO51228	BRCA	ICGC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.1944
p.T1030I	TCGA-YD-A89C	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	1024:1028	Mutation rewiring degron network	0.2778
p.T1030I	DO219501	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	1024:1028	Mutation rewiring degron network	0.2778
p.Y947S	DO227942	BRCA	ICGC	APSST	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.25
p.L1105V	DO50450	ESAD	ICGC	VSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.0556
p.R1733C	DO234208	ESAD	ICGC	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation altering degron motif	0.719
p.P1290T	DO234202	ESAD	ICGC	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation altering degron motif	0.5919
p.I1068F	DO222446	ESCA	ICGC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation altering degron motif	0.6304
p.R1771C	DO233270	GACA	ICGC	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.2778
p.K1296N	DO233273	GACA	ICGC	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation substituting flanking lysine	0.3333
p.K1296N	DO228936	LICA	ICGC	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation substituting flanking lysine	0.3333
p.S1028F	DO233195	GACA	ICGC	APSSS	DEG_SPOP_SBC_1	1024:1028	Mutation altering degron motif	0.7982
p.S1028F	DO222843	MELA	ICGC	APSSS	DEG_SPOP_SBC_1	1024:1028	Mutation altering degron motif	0.7982
p.S1028F	ACH-001569	Skin Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	1024:1028	Mutation altering degron motif	0.7982
p.S1279R	DO233653	GACA	ICGC	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation rewiring degron network	0.1389
p.S918Y	DO233811	GACA	ICGC	SSDSGE	DEG_Kelch_Keap1_1	903:908	Mutation rewiring degron network	0.0556
p.S918Y	DO233811	GACA	ICGC	DSGEPPT	DEG_SCF_TRCP1_1	905:911	Mutation rewiring degron network	0.1389
p.T1056N	DO229018	LICA	ICGC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.1389
p.D1060E	DO229031	LICA	ICGC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.25
p.S1127R	DO229038	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.1111
p.T911A	DO50883	LICA	ICGC	DSGEPPT	DEG_SCF_TRCP1_1	905:911	Mutation altering degron motif	0.7139
p.T1797I	DO231690	LINC	ICGC	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.1944
p.N1108I	DO45277	LIRI	ICGC	VSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.1389
p.S1744F	DO220877	MELA	ICGC	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation rewiring degron network	0.0833
p.G1055E	DO222875	MELA	ICGC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.1111
p.S1282P	DO35442	PACA	ICGC	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation rewiring degron network	0.2222
p.R1771H	DO228138	PBCA	ICGC	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.2778
p.M1764V	DO50432	PRAD	ICGC	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.0833
p.A1783E	DO50415	PRAD	ICGC	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.1667
p.A1783E	DO50415	PRAD	ICGC	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.1944
p.S1763Y	DO46941	RECA	ICGC	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.0556
p.A1766T	DO46941	RECA	ICGC	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.1389
p.P1726S	DO229456	SKCA	ICGC	DSGIGT	DEG_SCF_TRCP1_1	1719:1724	Mutation rewiring degron network	0.2778
p.P1726S	DO229456	SKCA	ICGC	DSGNRST	DEG_SCF_TRCP1_1	1729:1735	Mutation rewiring degron network	0.25
p.G1779S	SIDM01295	Pancreatic Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.2778
p.G1779S	SIDM01295	Pancreatic Carcinoma	GDSC	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.0833
p.V960I	SIDM00499	Prostate Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.1667
p.V960I	ACH-000956	Prostate Cancer	CCLE	APSST	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.1667
p.V960I	22RV1	prostate	COSMIC	APSST	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.1667
p.R1019Q	SIDM00425	Ovarian Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	1024:1028	Mutation rewiring degron network	0.1944
p.R1019Q	ACH-000663	Ovarian Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	1024:1028	Mutation rewiring degron network	0.1944
p.R1019Q	OVTOKO	ovary	COSMIC	APSSS	DEG_SPOP_SBC_1	1024:1028	Mutation rewiring degron network	0.1944
p.H915Y	SIDM00565	Oral Cavity Carcinoma	GDSC	SSDSGE	DEG_Kelch_Keap1_1	903:908	Mutation rewiring degron network	0.1389
p.H915Y	SIDM00565	Oral Cavity Carcinoma	GDSC	DSGEPPT	DEG_SCF_TRCP1_1	905:911	Mutation rewiring degron network	0.2222
p.H915Y	ACH-001626	Head and Neck Cancer	CCLE	SSDSGE	DEG_Kelch_Keap1_1	903:908	Mutation rewiring degron network	0.1389
p.H915Y	ACH-001626	Head and Neck Cancer	CCLE	DSGEPPT	DEG_SCF_TRCP1_1	905:911	Mutation rewiring degron network	0.2222
p.H915Y	OSC-20	upper aerodigestive tract	COSMIC	SSDSGE	DEG_Kelch_Keap1_1	903:908	Mutation rewiring degron network	0.1389
p.H915Y	OSC-20	upper aerodigestive tract	COSMIC	DSGEPPT	DEG_SCF_TRCP1_1	905:911	Mutation rewiring degron network	0.2222
p.S895P	SIDM00680	Colorectal Carcinoma	GDSC	SSDSGE	DEG_Kelch_Keap1_1	903:908	Mutation rewiring degron network	0.1111
p.S895P	SIDM00680	Colorectal Carcinoma	GDSC	DSGEPPT	DEG_SCF_TRCP1_1	905:911	Mutation rewiring degron network	0.0556
p.S895P	ACH-000957	Colon/Colorectal Cancer	CCLE	SSDSGE	DEG_Kelch_Keap1_1	903:908	Mutation rewiring degron network	0.1111
p.S895P	ACH-000957	Colon/Colorectal Cancer	CCLE	DSGEPPT	DEG_SCF_TRCP1_1	905:911	Mutation rewiring degron network	0.0556
p.S895P	LS-180	large intestine	COSMIC	SSDSGE	DEG_Kelch_Keap1_1	903:908	Mutation rewiring degron network	0.1111
p.S895P	LS-180	large intestine	COSMIC	DSGEPPT	DEG_SCF_TRCP1_1	905:911	Mutation rewiring degron network	0.0556
p.G1721R	SIDM00789	Colorectal Carcinoma	GDSC	DSGIGT	DEG_SCF_TRCP1_1	1719:1724	Mutation altering degron motif	0.7568
p.G1721R	ACH-000997	Colon/Colorectal Cancer	CCLE	DSGIGT	DEG_SCF_TRCP1_1	1719:1724	Mutation altering degron motif	0.7568
p.G1721R	HCT-15	large intestine	COSMIC	DSGIGT	DEG_SCF_TRCP1_1	1719:1724	Mutation altering degron motif	0.7568
p.I1061M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.2778
p.I1061M	ACH-002256	Leukemia	CCLE	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.2778
p.I1061M	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.2778
p.R1781H	SIDM00596	Endometrial Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.2222
p.R1781H	SIDM00596	Endometrial Carcinoma	GDSC	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.1389
p.R1781H	SIDM00487	Colorectal Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.2222
p.R1781H	SIDM00487	Colorectal Carcinoma	GDSC	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.1389
p.R1781H	ACH-000941	Endometrial/Uterine Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.2222
p.R1781H	ACH-000941	Endometrial/Uterine Cancer	CCLE	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.1389
p.R1781H	ACH-000954	Endometrial/Uterine Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.2222
p.R1781H	ACH-000954	Endometrial/Uterine Cancer	CCLE	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.1389
p.R1781H	ACH-000963	Colon/Colorectal Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.2222
p.R1781H	ACH-000963	Colon/Colorectal Cancer	CCLE	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.1389
p.R1781H	ACH-001517	Endometrial/Uterine Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.2222
p.R1781H	ACH-001517	Endometrial/Uterine Cancer	CCLE	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.1389
p.R1781H	ACH-001991	Primary	CCLE	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.2222
p.R1781H	ACH-001991	Primary	CCLE	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.1389
p.R1781H	CCK-81	large intestine	COSMIC	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.2222
p.R1781H	CCK-81	large intestine	COSMIC	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.1389
p.R1781H	HEC-1	endometrium	COSMIC	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.2222
p.R1781H	HEC-1	endometrium	COSMIC	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.1389
p.G1035W	SIDM00487	Colorectal Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	1024:1028	Mutation rewiring degron network	0.1389
p.G1035W	ACH-000963	Colon/Colorectal Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	1024:1028	Mutation rewiring degron network	0.1389
p.G1035W	CCK-81	large intestine	COSMIC	APSSS	DEG_SPOP_SBC_1	1024:1028	Mutation rewiring degron network	0.1389
p.D1060H	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.25
p.D1060H	SIDM00863	Burkitt's Lymphoma	GDSC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.25
p.T1072N	SIDM00940	Breast Carcinoma	GDSC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.25
p.T1072N	ACH-000212	Breast Cancer	CCLE	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.25
p.S1287T	SIDM00280	Gastric Carcinoma	GDSC	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation altering degron motif	0.6005
p.S1287T	ACH-000560	Gastric Cancer	CCLE	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation altering degron motif	0.6005
p.S1287T	ECC10	stomach	COSMIC	PSTPPIE	DEG_SCF_FBW7_2	1286:1292	Mutation altering degron motif	0.6005
p.P1070S	SIDM01059	Melanoma	GDSC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.3056
p.P1070S	ACH-000915	Skin Cancer	CCLE	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.3056
p.P1070S	IPC-298	skin	COSMIC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.3056
p.Q1064H	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation altering degron motif	0.647
p.Q1064H	ACH-000553	Lung Cancer	CCLE	LQTPRIS	DEG_SCF_FBW7_1	1063:1069	Mutation altering degron motif	0.647
p.E1109K	ACH-000169	Sarcoma	CCLE	VSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.1667
p.K1038M	ACH-000591	Brain Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	1024:1028	Mutation substituting flanking lysine	0.1667
p.D1793A	ACH-000894	Lung Cancer	CCLE	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.3056
p.D1793A	NCI-H1869	lung	COSMIC	VHSTS	DEG_SPOP_SBC_1	1788:1792	Mutation rewiring degron network	0.3056
p.S1763F	ACH-001568	Skin Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	1773:1777	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NCKAP5

UniProt ID: O14513

Entrez ID: 344148

Protein name: Nck-associated protein 5 (NAP-5) (Peripheral clock protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NCKAP5 in