DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
DSGNRST
Uniprot ID:
O14513
Source protein:
Nck-associated protein 5
Source gene:
NCKAP5
Class:
DEG_SCF_TRCP1_1
Location:
1729:1735
E3 ligase:
BTRC
DEGRON score:
0.7087
ASA_SCORE:
90.1286
COIL:
0.9119
CONS_SCORE:
0.8571
DSS_SCORE:
0.5289
HELIX:
0.0306
FCONS_SCORE:
0.9429
RIG_SCORE:
0.6102
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S1734L
TCGA-AP-A0LM
UCEC
TCGA
DSGNRST
DEG_SCF_TRCP1_1
0.6556
p.S1734L
DO43306
UCEC
ICGC
DSGNRST
DEG_SCF_TRCP1_1
0.6556
p.R1733H
TCGA-AX-A1CE
UCEC
TCGA
DSGNRST
DEG_SCF_TRCP1_1
0.7133
p.R1733H
TCGA-BR-7851
STAD
TCGA
DSGNRST
DEG_SCF_TRCP1_1
0.7133
p.R1733H
TCGA-RQ-A68N
DLBC
TCGA
DSGNRST
DEG_SCF_TRCP1_1
0.7133
p.R1733H
DO219921
DLBC
ICGC
DSGNRST
DEG_SCF_TRCP1_1
0.7133
p.R1733H
DO38711
STAD
ICGC
DSGNRST
DEG_SCF_TRCP1_1
0.7133
p.R1733H
DO42280
UCEC
ICGC
DSGNRST
DEG_SCF_TRCP1_1
0.7133
p.S1730L
TCGA-CA-6717
COAD
TCGA
DSGNRST
DEG_SCF_TRCP1_1
0.7667
p.S1730L
DO8264
COAD
ICGC
DSGNRST
DEG_SCF_TRCP1_1
0.7667
p.R1737C
TCGA-CV-A463
HNSC
TCGA
DSGNRST
DEG_SCF_TRCP1_1
0.2778
p.R1737C
DO10324
COAD
ICGC
DSGNRST
DEG_SCF_TRCP1_1
0.2778
p.R1737C
DO233687
GACA
ICGC
DSGNRST
DEG_SCF_TRCP1_1
0.2778
p.R1737C
DO52066
HNSC
ICGC
DSGNRST
DEG_SCF_TRCP1_1
0.2778
p.P1742A
TCGA-E7-A4IJ
BLCA
TCGA
DSGNRST
DEG_SCF_TRCP1_1
0.1389
p.P1742A
DO453
BLCA
ICGC
DSGNRST
DEG_SCF_TRCP1_1
0.1389
p.G1731E
TCGA-FR-A726
SKCM
TCGA
DSGNRST
DEG_SCF_TRCP1_1
0.7199
p.G1731E
DO48665
SKCM
ICGC
DSGNRST
DEG_SCF_TRCP1_1
0.7199
p.P1728L
TCGA-MP-A4TC
LUAD
TCGA
DSGNRST
DEG_SCF_TRCP1_1
0.3056
p.P1728L
DO45342
LUAD
ICGC
DSGNRST
DEG_SCF_TRCP1_1
0.3056
p.P1742Q
TCGA-NI-A4U2
LIHC
TCGA
DSGNRST
DEG_SCF_TRCP1_1
0.1389
p.P1742Q
DO48589
LIHC
ICGC
DSGNRST
DEG_SCF_TRCP1_1
0.1389
p.R1733C
DO234208
ESAD
ICGC
DSGNRST
DEG_SCF_TRCP1_1
0.719
p.S1744F
DO220877
MELA
ICGC
DSGNRST
DEG_SCF_TRCP1_1
0.0833
p.P1726S
DO229456
SKCA
ICGC
DSGNRST
DEG_SCF_TRCP1_1
0.25
Drug responses associated with NCKAP5 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGNRST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O14513
Nck-associated protein 5
DEG_SCF_TRCP1_1
1729:1735
DSGNRST
BTRC
0.7087
More...