DegronMD

Uniprot ID: O14513

Source protein: Nck-associated protein 5

Source gene: NCKAP5

Class: DEG_SCF_FBW7_2

Location: 1286:1292

E3 ligase: FBXW7

DEGRON score: 0.9831

ASA_SCORE: 94.9571

COIL: 0.9553

CONS_SCORE: 0.8571

DSS_SCORE: 0.7367

HELIX: 0.0133

FCONS_SCORE: 1.1786

RIG_SCORE: 0.5775

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1300E	TCGA-33-AAS8	LUSC	TCGA	PSTPPIE	DEG_SCF_FBW7_2	0.1111
p.Q1300E	DO219123	LUSC	ICGC	PSTPPIE	DEG_SCF_FBW7_2	0.1111
p.H1276D	TCGA-A7-A6VY	BRCA	TCGA	PSTPPIE	DEG_SCF_FBW7_2	0.0556
p.H1276D	DO50021	BRCA	ICGC	PSTPPIE	DEG_SCF_FBW7_2	0.0556
p.T1288M	TCGA-AA-3681	COAD	TCGA	PSTPPIE	DEG_SCF_FBW7_2	0.7423
p.T1288M	DO9682	COAD	ICGC	PSTPPIE	DEG_SCF_FBW7_2	0.7423
p.T1288M	DO233072	GACA	ICGC	PSTPPIE	DEG_SCF_FBW7_2	0.7423
p.T1288M	SIDM01293	Colorectal Carcinoma	GDSC	PSTPPIE	DEG_SCF_FBW7_2	0.7423
p.D1284Y	TCGA-AA-3977	COAD	TCGA	PSTPPIE	DEG_SCF_FBW7_2	0.2778
p.D1284Y	DO8730	COAD	ICGC	PSTPPIE	DEG_SCF_FBW7_2	0.2778
p.R1298C	TCGA-BP-5177	KIRC	TCGA	PSTPPIE	DEG_SCF_FBW7_2	0.1667
p.R1298C	DO16614	KIRC	ICGC	PSTPPIE	DEG_SCF_FBW7_2	0.1667
p.V1297A	TCGA-D8-A27H	BRCA	TCGA	PSTPPIE	DEG_SCF_FBW7_2	0.1944
p.V1297A	DO1249	BRCA	ICGC	PSTPPIE	DEG_SCF_FBW7_2	0.1944
p.R1298H	TCGA-L5-A43J	ESCA	TCGA	PSTPPIE	DEG_SCF_FBW7_2	0.1667
p.R1298H	SIDM01608	Endometrial Carcinoma	GDSC	PSTPPIE	DEG_SCF_FBW7_2	0.1667
p.R1298H	ACH-000990	Endometrial/Uterine Cancer	CCLE	PSTPPIE	DEG_SCF_FBW7_2	0.1667
p.P1290T	DO234202	ESAD	ICGC	PSTPPIE	DEG_SCF_FBW7_2	0.5919
p.K1296N	DO233273	GACA	ICGC	PSTPPIE	DEG_SCF_FBW7_2	0.3333
p.K1296N	DO228936	LICA	ICGC	PSTPPIE	DEG_SCF_FBW7_2	0.3333
p.S1279R	DO233653	GACA	ICGC	PSTPPIE	DEG_SCF_FBW7_2	0.1389
p.S1282P	DO35442	PACA	ICGC	PSTPPIE	DEG_SCF_FBW7_2	0.2222
p.S1287T	SIDM00280	Gastric Carcinoma	GDSC	PSTPPIE	DEG_SCF_FBW7_2	0.6005
p.S1287T	ACH-000560	Gastric Cancer	CCLE	PSTPPIE	DEG_SCF_FBW7_2	0.6005
p.S1287T	ECC10	stomach	COSMIC	PSTPPIE	DEG_SCF_FBW7_2	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14513	Nck-associated protein 5	DEG_SCF_FBW7_2	1286:1292	PSTPPIE	FBXW7	0.9831	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons