DegronMD

Uniprot ID: O14513

Source protein: Nck-associated protein 5

Source gene: NCKAP5

Class: DEG_SCF_TRCP1_1

Location: 905:911

E3 ligase: BTRC

DEGRON score: 0.9842

ASA_SCORE: 89.1429

COIL: 0.9497

CONS_SCORE: 0.4285

DSS_SCORE: 0.823

HELIX: 0.0277

FCONS_SCORE: 1.1786

RIG_SCORE: 0.4666

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S895L	TCGA-12-0616	GBM	TCGA	DSGEPPT	DEG_SCF_TRCP1_1	0.0556
p.S895L	DO12718	GBM	ICGC	DSGEPPT	DEG_SCF_TRCP1_1	0.0556
p.D905N	TCGA-55-7726	LUAD	TCGA	DSGEPPT	DEG_SCF_TRCP1_1	0.6932
p.D905N	DO25594	LUAD	ICGC	DSGEPPT	DEG_SCF_TRCP1_1	0.6932
p.A900V	TCGA-AZ-4614	COAD	TCGA	DSGEPPT	DEG_SCF_TRCP1_1	0.1944
p.A900V	DO10012	COAD	ICGC	DSGEPPT	DEG_SCF_TRCP1_1	0.1944
p.A900V	DO228581	GACA	ICGC	DSGEPPT	DEG_SCF_TRCP1_1	0.1944
p.E902K	TCGA-FW-A3R5	SKCM	TCGA	DSGEPPT	DEG_SCF_TRCP1_1	0.25
p.E902K	DO37406	SKCM	ICGC	DSGEPPT	DEG_SCF_TRCP1_1	0.25
p.P909T	TCGA-L9-A444	LUAD	TCGA	DSGEPPT	DEG_SCF_TRCP1_1	0.5919
p.P909T	DO234273	ESAD	ICGC	DSGEPPT	DEG_SCF_TRCP1_1	0.5919
p.P909T	DO26015	LUAD	ICGC	DSGEPPT	DEG_SCF_TRCP1_1	0.5919
p.S918Y	DO233811	GACA	ICGC	DSGEPPT	DEG_SCF_TRCP1_1	0.1389
p.T911A	DO50883	LICA	ICGC	DSGEPPT	DEG_SCF_TRCP1_1	0.7139
p.H915Y	SIDM00565	Oral Cavity Carcinoma	GDSC	DSGEPPT	DEG_SCF_TRCP1_1	0.2222
p.H915Y	ACH-001626	Head and Neck Cancer	CCLE	DSGEPPT	DEG_SCF_TRCP1_1	0.2222
p.H915Y	OSC-20	upper_aerodigestive_tract	COSMIC	DSGEPPT	DEG_SCF_TRCP1_1	0.2222
p.S895P	SIDM00680	Colorectal Carcinoma	GDSC	DSGEPPT	DEG_SCF_TRCP1_1	0.0556
p.S895P	ACH-000957	Colon/Colorectal Cancer	CCLE	DSGEPPT	DEG_SCF_TRCP1_1	0.0556
p.S895P	LS-180	large_intestine	COSMIC	DSGEPPT	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14513	Nck-associated protein 5	DEG_SCF_TRCP1_1	905:911	DSGEPPT	BTRC	0.9842	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons