DegronMD

Uniprot ID: O14513

Source protein: Nck-associated protein 5

Source gene: NCKAP5

Class: DEG_SCF_TRCP1_1

Location: 1719:1724

E3 ligase: BTRC

DEGRON score: 0.9843

ASA_SCORE: 75.7667

COIL: 0.87

CONS_SCORE: 1

DSS_SCORE: 0.5023

HELIX: 0.0302

FCONS_SCORE: 1.1

RIG_SCORE: 0.701

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M1715L	TCGA-3H-AB3S	MESO	TCGA	DSGIGT	DEG_SCF_TRCP1_1	0.2222
p.T1724P	TCGA-D7-6528	STAD	TCGA	DSGIGT	DEG_SCF_TRCP1_1	0.7031
p.T1724P	DO38547	STAD	ICGC	DSGIGT	DEG_SCF_TRCP1_1	0.7031
p.E1710K	TCGA-FS-A1ZA	SKCM	TCGA	DSGIGT	DEG_SCF_TRCP1_1	0.0833
p.E1710K	DO37551	SKCM	ICGC	DSGIGT	DEG_SCF_TRCP1_1	0.0833
p.P1728L	TCGA-MP-A4TC	LUAD	TCGA	DSGIGT	DEG_SCF_TRCP1_1	0.2222
p.P1728L	DO45342	LUAD	ICGC	DSGIGT	DEG_SCF_TRCP1_1	0.2222
p.P1726S	DO229456	SKCA	ICGC	DSGIGT	DEG_SCF_TRCP1_1	0.2778
p.G1721R	SIDM00789	Colorectal Carcinoma	GDSC	DSGIGT	DEG_SCF_TRCP1_1	0.7568
p.G1721R	ACH-000997	Colon/Colorectal Cancer	CCLE	DSGIGT	DEG_SCF_TRCP1_1	0.7568
p.G1721R	HCT-15	large_intestine	COSMIC	DSGIGT	DEG_SCF_TRCP1_1	0.7568

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCH0	Nck-associated protein 5-like	DEG_SCF_TRCP1_1	1123:1128	DSGIGT	BTRC	0.9892	More...
Q9NR48	Histone-lysine N-methyltransferase ASH1L	DEG_SCF_TRCP1_1	1200:1205	DSGIGT	BTRC	0.9795	More...
Q9Y6X0	SET-binding protein	DEG_SCF_TRCP1_1	868:873	DSGIGT	BTRC	0.9488	More...
O14513	Nck-associated protein 5	DEG_SCF_TRCP1_1	1719:1724	DSGIGT	BTRC	0.9843	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons