DegronMD

Uniprot ID: Q9HCH0

Source protein: Nck-associated protein 5-like

Source gene: NCKAP5L

Class: DEG_SCF_TRCP1_1

Location: 1123:1128

E3 ligase: BTRC

DEGRON score: 0.9892

ASA_SCORE: 73.7

COIL: 0.9065

CONS_SCORE: 0.9415

DSS_SCORE: 0.6402

HELIX: 0.0162

FCONS_SCORE: 1.1634

RIG_SCORE: 0.6239

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1127R	TCGA-66-2769	LUSC	TCGA	DSGIGT	DEG_SCF_TRCP1_1	0.6457
p.G1127R	TCGA-G9-6378	PRAD	TCGA	DSGIGT	DEG_SCF_TRCP1_1	0.6457
p.G1127R	DO26522	LUSC	ICGC	DSGIGT	DEG_SCF_TRCP1_1	0.6457
p.G1127R	DO36320	PRAD	ICGC	DSGIGT	DEG_SCF_TRCP1_1	0.6457
p.T1128I	DO220885	MELA	ICGC	DSGIGT	DEG_SCF_TRCP1_1	0.7078
p.P1131T	DO229229	THCA	ICGC	DSGIGT	DEG_SCF_TRCP1_1	0.25
p.D1123Y	DO229242	THCA	ICGC	DSGIGT	DEG_SCF_TRCP1_1	0.7325
p.T1113I	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DSGIGT	DEG_SCF_TRCP1_1	0.0556
p.T1113I	ACH-000981	Leukemia	CCLE	DSGIGT	DEG_SCF_TRCP1_1	0.0556
p.T1113I	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	DSGIGT	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCH0	Nck-associated protein 5-like	DEG_SCF_TRCP1_1	1123:1128	DSGIGT	BTRC	0.9892	More...
Q9NR48	Histone-lysine N-methyltransferase ASH1L	DEG_SCF_TRCP1_1	1200:1205	DSGIGT	BTRC	0.9795	More...
Q9Y6X0	SET-binding protein	DEG_SCF_TRCP1_1	868:873	DSGIGT	BTRC	0.9488	More...
O14513	Nck-associated protein 5	DEG_SCF_TRCP1_1	1719:1724	DSGIGT	BTRC	0.9843	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons