DegronMD - Q9HCH0(NCKAP5L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A778S	TCGA-19-5956	GBM	TCGA	PRSCLTKVE	DEG_APCC_DBOX_1	768:776	Mutation rewiring degron network	0.2778
p.A778S	DO13863	GBM	ICGC	PRSCLTKVE	DEG_APCC_DBOX_1	768:776	Mutation rewiring degron network	0.2778
p.Q534H	TCGA-22-1000	LUSC	TCGA	ALSTT	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.1389
p.Q534H	DO27060	LUSC	ICGC	ALSTT	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.1389
p.S1246T	TCGA-46-3769	LUSC	TCGA	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation altering degron motif	0.6005
p.S1246T	DO26590	LUSC	ICGC	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation altering degron motif	0.6005
p.G1127R	TCGA-66-2769	LUSC	TCGA	DSGIGT	DEG_SCF_TRCP1_1	1123:1128	Mutation altering degron motif	0.6457
p.G1127R	TCGA-G9-6378	PRAD	TCGA	DSGIGT	DEG_SCF_TRCP1_1	1123:1128	Mutation altering degron motif	0.6457
p.G1127R	DO26522	LUSC	ICGC	DSGIGT	DEG_SCF_TRCP1_1	1123:1128	Mutation altering degron motif	0.6457
p.G1127R	DO36320	PRAD	ICGC	DSGIGT	DEG_SCF_TRCP1_1	1123:1128	Mutation altering degron motif	0.6457
p.G784V	TCGA-66-2795	LUSC	TCGA	PRSCLTKVE	DEG_APCC_DBOX_1	768:776	Mutation rewiring degron network	0.1111
p.G784V	DO26710	LUSC	ICGC	PRSCLTKVE	DEG_APCC_DBOX_1	768:776	Mutation rewiring degron network	0.1111
p.R760W	TCGA-78-7155	LUAD	TCGA	ARVDLEPVS	DEG_APCC_DBOX_1	759:767	Mutation altering degron motif	0.8634
p.R760W	DO23590	LUAD	ICGC	ARVDLEPVS	DEG_APCC_DBOX_1	759:767	Mutation altering degron motif	0.8634
p.R760W	SIDM01695	Acute Myeloid Leukemia	GDSC	ARVDLEPVS	DEG_APCC_DBOX_1	759:767	Mutation altering degron motif	0.8634
p.R760W	ACH-000166	Leukemia	CCLE	ARVDLEPVS	DEG_APCC_DBOX_1	759:767	Mutation altering degron motif	0.8634
p.H423Y	TCGA-85-7697	LUSC	TCGA	PHSSS	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.3056
p.H423Y	DO27053	LUSC	ICGC	PHSSS	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.3056
p.G549C	TCGA-91-A4BC	LUAD	TCGA	ALSTT	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.2222
p.G549C	DO45422	LUAD	ICGC	ALSTT	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.2222
p.G1243S	TCGA-A5-A0G2	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation altering degron motif	0.5882
p.G1243S	DO41235	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation altering degron motif	0.5882
p.E676K	TCGA-AC-A5XS	BRCA	TCGA	LRDRLAALG	DEG_APCC_DBOX_1	661:669	Mutation rewiring degron network	0.1389
p.E676K	TCGA-CR-5248	HNSC	TCGA	LRDRLAALG	DEG_APCC_DBOX_1	661:669	Mutation rewiring degron network	0.1389
p.E676K	DO50023	BRCA	ICGC	LRDRLAALG	DEG_APCC_DBOX_1	661:669	Mutation rewiring degron network	0.1389
p.E676K	DO14694	HNSC	ICGC	LRDRLAALG	DEG_APCC_DBOX_1	661:669	Mutation rewiring degron network	0.1389
p.E676K	SIDM00933	Breast Carcinoma	GDSC	LRDRLAALG	DEG_APCC_DBOX_1	661:669	Mutation rewiring degron network	0.1389
p.E676K	SIDM00473	Oral Cavity Carcinoma	GDSC	LRDRLAALG	DEG_APCC_DBOX_1	661:669	Mutation rewiring degron network	0.1389
p.E676K	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRDRLAALG	DEG_APCC_DBOX_1	661:669	Mutation rewiring degron network	0.1389
p.E676K	CAL-51	breast	COSMIC	LRDRLAALG	DEG_APCC_DBOX_1	661:669	Mutation rewiring degron network	0.1389
p.E676K	PE/CA-PJ15	upper aerodigestive tract	COSMIC	LRDRLAALG	DEG_APCC_DBOX_1	661:669	Mutation rewiring degron network	0.1389
p.K1232N	TCGA-AX-A05Z	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation substituting flanking lysine	0.1667
p.K1232N	TCGA-EO-A22U	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation substituting flanking lysine	0.1667
p.K1232N	DO40884	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation substituting flanking lysine	0.1667
p.K1232N	DO43755	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation substituting flanking lysine	0.1667
p.R1254Q	TCGA-AZ-6600	COAD	TCGA	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation rewiring degron network	0.1111
p.R1254Q	DO10774	COAD	ICGC	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation rewiring degron network	0.1111
p.R1254Q	SIDM02074	Esophageal Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation rewiring degron network	0.1111
p.R1254Q	SIDM01617	Endometrial Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation rewiring degron network	0.1111
p.R1254Q	ACH-000994	Endometrial/Uterine Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation rewiring degron network	0.1111
p.M1250T	TCGA-CR-7402	HNSC	TCGA	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation rewiring degron network	0.2222
p.M1250T	DO15727	HNSC	ICGC	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation rewiring degron network	0.2222
p.R652G	TCGA-EE-A2A2	SKCM	TCGA	LRDRLAALG	DEG_APCC_DBOX_1	661:669	Mutation rewiring degron network	0.0833
p.R652G	DO37583	SKCM	ICGC	LRDRLAALG	DEG_APCC_DBOX_1	661:669	Mutation rewiring degron network	0.0833
p.D762N	TCGA-EE-A3J5	SKCM	TCGA	ARVDLEPVS	DEG_APCC_DBOX_1	759:767	Mutation altering degron motif	0.5821
p.D762N	DO47331	SKCM	ICGC	ARVDLEPVS	DEG_APCC_DBOX_1	759:767	Mutation altering degron motif	0.5821
p.L1249F	TCGA-GC-A6I3	BLCA	TCGA	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation rewiring degron network	0.25
p.L1249F	DO219025	BLCA	ICGC	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation rewiring degron network	0.25
p.C1251W	TCGA-NJ-A4YQ	LUAD	TCGA	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation rewiring degron network	0.1944
p.C1251W	DO218944	LUAD	ICGC	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation rewiring degron network	0.1944
p.L535P	TCGA-UY-A8OB	BLCA	TCGA	ALSTT	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.1667
p.L535P	DO219037	BLCA	ICGC	ALSTT	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.1667
p.G295D	TCGA-VQ-A91D	STAD	TCGA	PGSSS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.6087
p.G295D	DO232224	PBCA	ICGC	PGSSS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.6087
p.G295D	DO51783	STAD	ICGC	PGSSS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.6087
p.G295D	SIDM00193	Colorectal Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.6087
p.G295D	ACH-000991	Colon/Colorectal Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.6087
p.G295D	SNU-81	large intestine	COSMIC	PGSSS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.6087
p.Q1255K	DO229029	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation rewiring degron network	0.0833
p.T1128I	DO220885	MELA	ICGC	DSGIGT	DEG_SCF_TRCP1_1	1123:1128	Mutation altering degron motif	0.7078
p.P424L	DO34680	PACA	ICGC	PHSSS	DEG_SPOP_SBC_1	424:428	Mutation altering degron motif	0.7582
p.P653T	DO32817	PACA	ICGC	LRDRLAALG	DEG_APCC_DBOX_1	661:669	Mutation rewiring degron network	0.1111
p.P653T	SIDM01135	Pancreatic Carcinoma	GDSC	LRDRLAALG	DEG_APCC_DBOX_1	661:669	Mutation rewiring degron network	0.1111
p.P653T	PANC-10-05	pancreas	COSMIC	LRDRLAALG	DEG_APCC_DBOX_1	661:669	Mutation rewiring degron network	0.1111
p.S754F	DO32831	PACA	ICGC	ARVDLEPVS	DEG_APCC_DBOX_1	759:767	Mutation rewiring degron network	0.1944
p.P1131T	DO229229	THCA	ICGC	DSGIGT	DEG_SCF_TRCP1_1	1123:1128	Mutation rewiring degron network	0.25
p.D1123Y	DO229242	THCA	ICGC	DSGIGT	DEG_SCF_TRCP1_1	1123:1128	Mutation altering degron motif	0.7325
p.P294T	SIDM01293	Colorectal Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.7031
p.T1113I	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DSGIGT	DEG_SCF_TRCP1_1	1123:1128	Mutation rewiring degron network	0.0556
p.T1113I	ACH-000981	Leukemia	CCLE	DSGIGT	DEG_SCF_TRCP1_1	1123:1128	Mutation rewiring degron network	0.0556
p.T1113I	DND-41	haematopoietic and lymphoid tissue	COSMIC	DSGIGT	DEG_SCF_TRCP1_1	1123:1128	Mutation rewiring degron network	0.0556
p.S432N	SIDM01062	Breast Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	424:428	Mutation blocking phosphorylation signal	0.6667
p.S432N	ACH-000643	Breast Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	424:428	Mutation blocking phosphorylation signal	0.6667
p.S432N	HDQ-P1	breast	COSMIC	PHSSS	DEG_SPOP_SBC_1	424:428	Mutation blocking phosphorylation signal	0.6667
p.R536K	SIDM01206	Neuroblastoma	GDSC	ALSTT	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.1944
p.R536K	ACH-002248	Neuroblastoma	CCLE	ALSTT	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.1944
p.R536K	IMR-5	autonomic ganglia	COSMIC	ALSTT	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.1944
p.R662W	SIDM00447	B-Lymphoblastic Leukemia	GDSC	LRDRLAALG	DEG_APCC_DBOX_1	661:669	Mutation altering degron motif	0.8634
p.R662W	ACH-000960	Leukemia	CCLE	LRDRLAALG	DEG_APCC_DBOX_1	661:669	Mutation altering degron motif	0.8634
p.R662W	REH	haematopoietic and lymphoid tissue	COSMIC	LRDRLAALG	DEG_APCC_DBOX_1	661:669	Mutation altering degron motif	0.8634
p.S299F	SIDM01060	Melanoma	GDSC	PGSSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.3056
p.S299F	ACH-000882	Skin Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.3056
p.S299F	IGR-1	skin	COSMIC	PGSSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.3056
p.R651W	SIDM00694	Other Solid Cancers	GDSC	LRDRLAALG	DEG_APCC_DBOX_1	661:669	Mutation rewiring degron network	0.0556
p.R651W	ACH-000538	Gastric Cancer	CCLE	LRDRLAALG	DEG_APCC_DBOX_1	661:669	Mutation rewiring degron network	0.0556
p.R651W	HUTU-80	small intestine	COSMIC	LRDRLAALG	DEG_APCC_DBOX_1	661:669	Mutation rewiring degron network	0.0556
p.A1241E	SIDM00556	Neuroblastoma	GDSC	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation rewiring degron network	0.3056
p.A1241E	SIDM00018	Acute Myeloid Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation rewiring degron network	0.3056
p.A1241E	KP-N-YN	autonomic ganglia	COSMIC	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation rewiring degron network	0.3056
p.A1241E	KO52	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation rewiring degron network	0.3056
p.G418D	SIDM00941	Kidney Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.1667
p.G418D	SIDM00140	Melanoma	GDSC	PHSSS	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.1667
p.A749T	SIDM01133	Other Solid Cancers	GDSC	ARVDLEPVS	DEG_APCC_DBOX_1	759:767	Mutation rewiring degron network	0.0556
p.A749T	ACH-002177	Lung Cancer	CCLE	ARVDLEPVS	DEG_APCC_DBOX_1	759:767	Mutation rewiring degron network	0.0556
p.A749T	NCI-H835	lung	COSMIC	ARVDLEPVS	DEG_APCC_DBOX_1	759:767	Mutation rewiring degron network	0.0556
p.T286N	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PGSSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1111
p.T286N	ACH-000964	Leukemia	CCLE	PGSSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1111
p.P538L	SIDM01480	Ovarian Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.25
p.P538L	ACH-000256	Ovarian Cancer	CCLE	ALSTT	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.25
p.L786M	ACH-000903	Thyroid Cancer	CCLE	PRSCLTKVE	DEG_APCC_DBOX_1	768:776	Mutation rewiring degron network	0.0556
p.D663G	ACH-000971	Colon/Colorectal Cancer	CCLE	LRDRLAALG	DEG_APCC_DBOX_1	661:669	Mutation altering degron motif	0.6087
p.Q429K	ACH-001495	Endometrial/Uterine Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.3056
p.S301F	ACH-001495	Endometrial/Uterine Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.25
p.T544S	ACH-001523	Skin Cancer	CCLE	ALSTT	DEG_SPOP_SBC_1	541:545	Mutation altering degron motif	0.6005
p.M1250L	ACH-001844	Bile Duct Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	1242:1246	Mutation rewiring degron network	0.2222
p.G289S	ACH-002005	Skin Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NCKAP5L

UniProt ID: Q9HCH0

Entrez ID: 57701

Protein name: Nck-associated protein 5-like (NCKAP5-like) (Centrosomal protein of 169 kDa) (Cep169)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NCKAP5L in