DegronMD

Uniprot ID: Q9HCH0

Source protein: Nck-associated protein 5-like

Source gene: NCKAP5L

Class: DEG_APCC_DBOX_1

Location: 661:669

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9984

ASA_SCORE: 79.8667

COIL: 0.4684

CONS_SCORE: 0.919

DSS_SCORE: 0.7348

HELIX: 0.5217

FCONS_SCORE: 1.3485

RIG_SCORE: 0.7329

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E676K	TCGA-AC-A5XS	BRCA	TCGA	LRDRLAALG	DEG_APCC_DBOX_1	0.1389
p.E676K	TCGA-CR-5248	HNSC	TCGA	LRDRLAALG	DEG_APCC_DBOX_1	0.1389
p.E676K	DO50023	BRCA	ICGC	LRDRLAALG	DEG_APCC_DBOX_1	0.1389
p.E676K	DO14694	HNSC	ICGC	LRDRLAALG	DEG_APCC_DBOX_1	0.1389
p.E676K	SIDM00933	Breast Carcinoma	GDSC	LRDRLAALG	DEG_APCC_DBOX_1	0.1389
p.E676K	SIDM00473	Oral Cavity Carcinoma	GDSC	LRDRLAALG	DEG_APCC_DBOX_1	0.1389
p.E676K	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRDRLAALG	DEG_APCC_DBOX_1	0.1389
p.E676K	CAL-51	breast	COSMIC	LRDRLAALG	DEG_APCC_DBOX_1	0.1389
p.E676K	PE/CA-PJ15	upper_aerodigestive_tract	COSMIC	LRDRLAALG	DEG_APCC_DBOX_1	0.1389
p.R652G	TCGA-EE-A2A2	SKCM	TCGA	LRDRLAALG	DEG_APCC_DBOX_1	0.0833
p.R652G	DO37583	SKCM	ICGC	LRDRLAALG	DEG_APCC_DBOX_1	0.0833
p.P653T	DO32817	PACA	ICGC	LRDRLAALG	DEG_APCC_DBOX_1	0.1111
p.P653T	SIDM01135	Pancreatic Carcinoma	GDSC	LRDRLAALG	DEG_APCC_DBOX_1	0.1111
p.P653T	PANC-10-05	pancreas	COSMIC	LRDRLAALG	DEG_APCC_DBOX_1	0.1111
p.R662W	SIDM00447	B-Lymphoblastic Leukemia	GDSC	LRDRLAALG	DEG_APCC_DBOX_1	0.8634
p.R662W	ACH-000960	Leukemia	CCLE	LRDRLAALG	DEG_APCC_DBOX_1	0.8634
p.R662W	REH	haematopoietic_and_lymphoid_tissue	COSMIC	LRDRLAALG	DEG_APCC_DBOX_1	0.8634
p.R651W	SIDM00694	Other Solid Cancers	GDSC	LRDRLAALG	DEG_APCC_DBOX_1	0.0556
p.R651W	ACH-000538	Gastric Cancer	CCLE	LRDRLAALG	DEG_APCC_DBOX_1	0.0556
p.R651W	HUTU-80	small_intestine	COSMIC	LRDRLAALG	DEG_APCC_DBOX_1	0.0556
p.D663G	ACH-000971	Colon/Colorectal Cancer	CCLE	LRDRLAALG	DEG_APCC_DBOX_1	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCH0	Nck-associated protein 5-like	DEG_APCC_DBOX_1	661:669	LRDRLAALG	APC,CDC20,FZR1	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons