DegronMD

Uniprot ID: Q9HCH0

Source protein: Nck-associated protein 5-like

Source gene: NCKAP5L

Class: DEG_APCC_DBOX_1

Location: 759:767

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9504

ASA_SCORE: 92.9667

COIL: 0.9072

CONS_SCORE: 0.7373

DSS_SCORE: 0.4143

HELIX: 0.0288

FCONS_SCORE: 0.9952

RIG_SCORE: 0.7254

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R760W	TCGA-78-7155	LUAD	TCGA	ARVDLEPVS	DEG_APCC_DBOX_1	0.8634
p.R760W	DO23590	LUAD	ICGC	ARVDLEPVS	DEG_APCC_DBOX_1	0.8634
p.R760W	SIDM01695	Acute Myeloid Leukemia	GDSC	ARVDLEPVS	DEG_APCC_DBOX_1	0.8634
p.R760W	ACH-000166	Leukemia	CCLE	ARVDLEPVS	DEG_APCC_DBOX_1	0.8634
p.D762N	TCGA-EE-A3J5	SKCM	TCGA	ARVDLEPVS	DEG_APCC_DBOX_1	0.5821
p.D762N	DO47331	SKCM	ICGC	ARVDLEPVS	DEG_APCC_DBOX_1	0.5821
p.S754F	DO32831	PACA	ICGC	ARVDLEPVS	DEG_APCC_DBOX_1	0.1944
p.A749T	SIDM01133	Other Solid Cancers	GDSC	ARVDLEPVS	DEG_APCC_DBOX_1	0.0556
p.A749T	ACH-002177	Lung Cancer	CCLE	ARVDLEPVS	DEG_APCC_DBOX_1	0.0556
p.A749T	NCI-H835	lung	COSMIC	ARVDLEPVS	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCH0	Nck-associated protein 5-like	DEG_APCC_DBOX_1	759:767	ARVDLEPVS	APC,CDC20,FZR1	0.9504	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons