DegronMD

Uniprot ID: Q9HCH0

Source protein: Nck-associated protein 5-like

Source gene: NCKAP5L

Class: DEG_APCC_DBOX_1

Location: 768:776

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7432

ASA_SCORE: 93.0778

COIL: 0.679

CONS_SCORE: 0.8013

DSS_SCORE: 0.3559

HELIX: 0.2964

FCONS_SCORE: 1.1254

RIG_SCORE: 0.7942

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A778S	TCGA-19-5956	GBM	TCGA	PRSCLTKVE	DEG_APCC_DBOX_1	0.2778
p.A778S	DO13863	GBM	ICGC	PRSCLTKVE	DEG_APCC_DBOX_1	0.2778
p.G784V	TCGA-66-2795	LUSC	TCGA	PRSCLTKVE	DEG_APCC_DBOX_1	0.1111
p.G784V	DO26710	LUSC	ICGC	PRSCLTKVE	DEG_APCC_DBOX_1	0.1111
p.L786M	ACH-000903	Thyroid Cancer	CCLE	PRSCLTKVE	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCH0	Nck-associated protein 5-like	DEG_APCC_DBOX_1	768:776	PRSCLTKVE	APC,CDC20,FZR1	0.7432	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons