DegronMD

Uniprot ID: Q9HCH0

Source protein: Nck-associated protein 5-like

Source gene: NCKAP5L

Class: DEG_SPOP_SBC_1

Location: 424:428

E3 ligase: SPOP

DEGRON score: 0.8761

ASA_SCORE: 79.8

COIL: 0.8796

CONS_SCORE: 0.6502

DSS_SCORE: 0.74

HELIX: 0.0868

FCONS_SCORE: 0.9092

RIG_SCORE: 0.5469

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P424L	DO34680	PACA	ICGC	PHSSS	DEG_SPOP_SBC_1	0.7582
p.S432N	SIDM01062	Breast Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.6667
p.S432N	ACH-000643	Breast Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	0.6667
p.S432N	HDQ-P1	breast	COSMIC	PHSSS	DEG_SPOP_SBC_1	0.6667
p.H423Y	TCGA-85-7697	LUSC	TCGA	PHSSS	DEG_SPOP_SBC_1	0.3056
p.H423Y	DO27053	LUSC	ICGC	PHSSS	DEG_SPOP_SBC_1	0.3056
p.Q429K	ACH-001495	Endometrial/Uterine Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	0.3056
p.G418D	SIDM00941	Kidney Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.1667
p.G418D	SIDM00140	Melanoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.1667

Showing 1 to 9 of 9 entries

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Drug responses associated with NCKAP5L mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PHSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	304:308	PHSSS	SPOP	0.9956	More...
Q9UIF9	Bromodomain adjacent to zinc finger domain protein 2A	DEG_SPOP_SBC_1	74:78	PHSSS	SPOP	0.969	More...
Q8TDJ6	DmX-like protein 2	DEG_SPOP_SBC_1	956:960	PHSSS	SPOP	0.985	More...
P29372	DNA-3-methyladenine glycosylase	DEG_SPOP_SBC_1	45:49	PHSSS	SPOP	0.9962	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	3950:3954	PHSSS	SPOP	0.969	More...
Q14C86	GTPase-activating protein and VPS9 domain-containing protein 1	DEG_SPOP_SBC_1	944:948	PHSSS	SPOP	0.9376	More...
O60229	Kalirin	DEG_SPOP_SBC_1	732:736	PHSSS	SPOP	0.9258	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4662:4666	PHSSS	SPOP	0.7998	More...
Q9HCH0	Nck-associated protein 5-like	DEG_SPOP_SBC_1	424:428	PHSSS	SPOP	0.8761	More...
Q9C0B5	Palmitoyltransferase ZDHHC5	DEG_SPOP_SBC_1	368:372	PHSSS	SPOP	0.9986	More...
O75747	Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma	DEG_SPOP_SBC_1	30:34	PHSSS	SPOP	0.9099	More...
Q8NEL9	Phospholipase DDHD1	DEG_SPOP_SBC_1	802:806	PHSSS	SPOP	0.812	More...
Q9H6K5	Proline-rich protein 36	DEG_SPOP_SBC_1	357:361	PHSSS	SPOP	0.9525	More...
Q96G01	Protein bicaudal D homolog 1	DEG_SPOP_SBC_1	957:961	PHSSS	SPOP	0.9246	More...
Q76I76	Protein phosphatase Slingshot homolog 2	DEG_SPOP_SBC_1	1079:1083	PHSSS	SPOP	0.7902	More...
Q76I76	Protein phosphatase Slingshot homolog 2	DEG_SPOP_SBC_1	1213:1217	PHSSS	SPOP	0.9976	More...
Q9P1A2	Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like	DEG_SPOP_SBC_1	345:349	PHSSS	SPOP	0.5244	More...
O14559	Rho GTPase-activating protein 33	DEG_SPOP_SBC_1	658:662	PHSSS	SPOP	0.9958	More...
O94933	SLIT and NTRK-like protein 3	DEG_SPOP_SBC_1	296:300	PHSSS	SPOP	0.8737	More...
P48436	Transcription factor SOX-9	DEG_SPOP_SBC_1	212:216	PHSSS	SPOP	0.9783	More...
Q5VYM1	Uncharacterized protein C9orf131	DEG_SPOP_SBC_1	840:844	PHSSS	SPOP	0.8857	More...
Q8IYI8	Zinc finger protein 440	DEG_SPOP_SBC_1	378:382	PHSSS	SPOP	0.7442	More...
Q13129	Zinc finger protein Rlf	DEG_SPOP_SBC_1	1828:1832	PHSSS	SPOP	0.9974	More...

Showing 1 to 23 of 23 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PHSSS

Degron related mutations and impact score

Drug responses associated with NCKAP5L mutations

All proteins holding degron of PHSSS