DegronMD - Q96G01(BICD1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V829M	TCGA-37-4132	LUSC	TCGA	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.7208
p.V829M	DO26528	LUSC	ICGC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.7208
p.K596N	TCGA-55-8506	LUAD	TCGA	PTKTPTIS	DEG_SCF_FBW7_1	594:601	Mutation altering degron motif	0.5806
p.K596N	DO45390	LUAD	ICGC	PTKTPTIS	DEG_SCF_FBW7_1	594:601	Mutation altering degron motif	0.5806
p.P931R	TCGA-55-8507	LUAD	TCGA	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation altering degron motif	0.6401
p.E591K	TCGA-78-7539	LUAD	TCGA	PTKTPTIS	DEG_SCF_FBW7_1	594:601	Mutation rewiring degron network	0.25
p.E591K	DO26210	LUAD	ICGC	PTKTPTIS	DEG_SCF_FBW7_1	594:601	Mutation rewiring degron network	0.25
p.H290Y	TCGA-93-7347	LUAD	TCGA	DYR	CBL_MET	299:301	Mutation rewiring degron network	0.0833
p.H290Y	DO24364	LUAD	ICGC	DYR	CBL_MET	299:301	Mutation rewiring degron network	0.0833
p.T605A	TCGA-AA-3811	COAD	TCGA	PTKTPTIS	DEG_SCF_FBW7_1	594:601	Mutation blocking phosphorylation signal	0.6667
p.T605A	DO7962	COAD	ICGC	PTKTPTIS	DEG_SCF_FBW7_1	594:601	Mutation blocking phosphorylation signal	0.6667
p.P602S	TCGA-BF-AAP1	SKCM	TCGA	PTKTPTIS	DEG_SCF_FBW7_1	594:601	Mutation rewiring degron network	0.3056
p.P602S	DO219464	SKCM	ICGC	PTKTPTIS	DEG_SCF_FBW7_1	594:601	Mutation rewiring degron network	0.3056
p.G939R	TCGA-C5-A7UC	CESC	TCGA	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation rewiring degron network	0.1667
p.G939R	TCGA-W3-AA1O	SKCM	TCGA	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation rewiring degron network	0.1667
p.G939R	DO49889	CESC	ICGC	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation rewiring degron network	0.1667
p.G939R	DO51274	SKCM	ICGC	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation rewiring degron network	0.1667
p.P842Q	TCGA-CN-6010	HNSC	TCGA	EASVTVPTI	DEG_COP1_1	824:832	Mutation rewiring degron network	0.0556
p.P842Q	DO14766	HNSC	ICGC	EASVTVPTI	DEG_COP1_1	824:832	Mutation rewiring degron network	0.0556
p.P931Q	TCGA-D3-A2J6	SKCM	TCGA	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation altering degron motif	0.5924
p.L469I	TCGA-D3-A2JC	SKCM	TCGA	IQMYDE	LIG_APCC_ABBA_1	459:464	Mutation rewiring degron network	0.1944
p.L469I	TCGA-D3-A2JC	SKCM	TCGA	KIQMYDE	LIG_APCC_ABBAyCdc20_2	458:464	Mutation rewiring degron network	0.1944
p.L469I	DO47578	SKCM	ICGC	IQMYDE	LIG_APCC_ABBA_1	459:464	Mutation rewiring degron network	0.1944
p.L469I	DO47578	SKCM	ICGC	KIQMYDE	LIG_APCC_ABBAyCdc20_2	458:464	Mutation rewiring degron network	0.1944
p.E464K	TCGA-D3-A5GU	SKCM	TCGA	IQMYDE	LIG_APCC_ABBA_1	459:464	Mutation altering degron motif	0.7022
p.E464K	TCGA-D3-A5GU	SKCM	TCGA	KIQMYDE	LIG_APCC_ABBAyCdc20_2	458:464	Mutation altering degron motif	0.7022
p.E464K	DO47584	SKCM	ICGC	IQMYDE	LIG_APCC_ABBA_1	459:464	Mutation altering degron motif	0.7022
p.E464K	DO47584	SKCM	ICGC	KIQMYDE	LIG_APCC_ABBAyCdc20_2	458:464	Mutation altering degron motif	0.7022
p.S609T	TCGA-D6-A6EK	HNSC	TCGA	PTKTPTIS	DEG_SCF_FBW7_1	594:601	Mutation rewiring degron network	0.1111
p.S609T	DO52080	HNSC	ICGC	PTKTPTIS	DEG_SCF_FBW7_1	594:601	Mutation rewiring degron network	0.1111
p.E470Q	TCGA-DK-A2I4	BLCA	TCGA	IQMYDE	LIG_APCC_ABBA_1	459:464	Mutation rewiring degron network	0.1667
p.E470Q	TCGA-DK-A2I4	BLCA	TCGA	KIQMYDE	LIG_APCC_ABBAyCdc20_2	458:464	Mutation rewiring degron network	0.1667
p.E470Q	DO465	BLCA	ICGC	IQMYDE	LIG_APCC_ABBA_1	459:464	Mutation rewiring degron network	0.1667
p.E470Q	DO465	BLCA	ICGC	KIQMYDE	LIG_APCC_ABBAyCdc20_2	458:464	Mutation rewiring degron network	0.1667
p.A964T	TCGA-E6-A1LX	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	957:961	Mutation rewiring degron network	0.25
p.A964T	DO41020	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	957:961	Mutation rewiring degron network	0.25
p.A964T	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	957:961	Mutation rewiring degron network	0.25
p.A964T	ACH-000925	Lung Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	957:961	Mutation rewiring degron network	0.25
p.P920S	TCGA-EE-A2M5	SKCM	TCGA	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation rewiring degron network	0.1944
p.P920S	DO222423	MELA	ICGC	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation rewiring degron network	0.1944
p.P920S	DO37425	SKCM	ICGC	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation rewiring degron network	0.1944
p.A938V	TCGA-EE-A3J5	SKCM	TCGA	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation rewiring degron network	0.1944
p.A938V	DO47331	SKCM	ICGC	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation rewiring degron network	0.1944
p.D922Y	TCGA-G7-6797	KIRP	TCGA	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation rewiring degron network	0.25
p.D922Y	DO20917	KIRP	ICGC	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation rewiring degron network	0.25
p.T917A	TCGA-HU-8602	STAD	TCGA	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation rewiring degron network	0.1111
p.T917A	DO47829	STAD	ICGC	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation rewiring degron network	0.1111
p.P931L	TCGA-MA-AA42	CESC	TCGA	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation altering degron motif	0.6471
p.G939E	TCGA-W3-AA1O	SKCM	TCGA	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation rewiring degron network	0.1667
p.G939E	DO51274	SKCM	ICGC	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation rewiring degron network	0.1667
p.V918L	TCGA-ZP-A9D1	LIHC	TCGA	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation rewiring degron network	0.1389
p.V918L	DO52332	LIHC	ICGC	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation rewiring degron network	0.1389
p.R830C	DO228328	BRCA	ICGC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.8301
p.R830C	DO219724	CESC	ICGC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.8301
p.R830C	DO232761	PBCA	ICGC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.8301
p.S824N	DO5682	BRCA	ICGC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.7069
p.V603A	DO222798	COCA	ICGC	PTKTPTIS	DEG_SCF_FBW7_1	594:601	Mutation rewiring degron network	0.2778
p.T473A	DO222884	COCA	ICGC	IQMYDE	LIG_APCC_ABBA_1	459:464	Mutation rewiring degron network	0.0833
p.T473A	DO222884	COCA	ICGC	KIQMYDE	LIG_APCC_ABBAyCdc20_2	458:464	Mutation rewiring degron network	0.0833
p.P828L	DO234357	ESAD	ICGC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.7582
p.P828L	DO41235	UCEC	ICGC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.7582
p.L305V	DO218442	GACA	ICGC	DYR	CBL_MET	299:301	Mutation rewiring degron network	0.2222
p.V930L	DO233909	GACA	ICGC	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation altering degron motif	0.6765
p.A606S	DO229031	LICA	ICGC	PTKTPTIS	DEG_SCF_FBW7_1	594:601	Mutation rewiring degron network	0.1944
p.K971N	DO229006	LICA	ICGC	PHSSS	DEG_SPOP_SBC_1	957:961	Mutation substituting flanking lysine	0.1667
p.R830G	DO45412	LUAD	ICGC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.7568
p.D942Y	DO231204	LUSC	ICGC	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation rewiring degron network	0.0833
p.H831L	DO26425	LUSC	ICGC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.7313
p.L952F	DO222413	MELA	ICGC	PHSSS	DEG_SPOP_SBC_1	957:961	Mutation rewiring degron network	0.1944
p.P830L	DO232224	PBCA	ICGC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.7582
p.R830S	DO37901	SKCM	ICGC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.7427
p.T467I	SIDM02039	Colorectal Carcinoma	GDSC	IQMYDE	LIG_APCC_ABBA_1	459:464	Mutation rewiring degron network	0.25
p.T467I	SIDM02039	Colorectal Carcinoma	GDSC	KIQMYDE	LIG_APCC_ABBAyCdc20_2	458:464	Mutation rewiring degron network	0.25
p.A927V	SIDM02015	Colorectal Carcinoma	GDSC	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation altering degron motif	0.5825
p.V827D	SIDM00845	Burkitt's Lymphoma	GDSC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.6674
p.V827D	ACH-000786	Lymphoma	CCLE	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.6674
p.V827D	Daudi	haematopoietic and lymphoid tissue	COSMIC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.6674
p.C943Y	SIDM00845	Burkitt's Lymphoma	GDSC	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation rewiring degron network	0.0556
p.E824K	SIDM00027	Kidney Carcinoma	GDSC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.7022
p.E824K	ACH-001192	Bone Cancer	CCLE	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.7022
p.E824K	SK-NEP-1	kidney	COSMIC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.7022
p.V918M	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation rewiring degron network	0.1389
p.V918M	EBC-1	lung	COSMIC	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation rewiring degron network	0.1389
p.T605I	SIDM00683	Prostate Carcinoma	GDSC	PTKTPTIS	DEG_SCF_FBW7_1	594:601	Mutation blocking phosphorylation signal	0.6667
p.T605I	LNCaP-Clone-FGC	prostate	COSMIC	PTKTPTIS	DEG_SCF_FBW7_1	594:601	Mutation blocking phosphorylation signal	0.6667
p.S814T	SIDM00929	Chondrosarcoma	GDSC	EASVTVPTI	DEG_COP1_1	824:832	Mutation rewiring degron network	0.0556
p.S814T	ACH-000516	Bone Cancer	CCLE	EASVTVPTI	DEG_COP1_1	824:832	Mutation rewiring degron network	0.0556
p.S814T	CAL-78	bone	COSMIC	EASVTVPTI	DEG_COP1_1	824:832	Mutation rewiring degron network	0.0556
p.I600M	SIDM00861	Ovarian Carcinoma	GDSC	PTKTPTIS	DEG_SCF_FBW7_1	594:601	Mutation altering degron motif	0.6507
p.I600M	ACH-000906	Ovarian Cancer	CCLE	PTKTPTIS	DEG_SCF_FBW7_1	594:601	Mutation altering degron motif	0.6507
p.I600M	ES-2	ovary	COSMIC	PTKTPTIS	DEG_SCF_FBW7_1	594:601	Mutation altering degron motif	0.6507
p.S826P	ACH-000786	Lymphoma	CCLE	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.6752
p.S826P	Daudi	haematopoietic and lymphoid tissue	COSMIC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.6752
p.T467A	ACH-000937	Leukemia	CCLE	IQMYDE	LIG_APCC_ABBA_1	459:464	Mutation rewiring degron network	0.25
p.T467A	ACH-000937	Leukemia	CCLE	KIQMYDE	LIG_APCC_ABBAyCdc20_2	458:464	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BICD1

UniProt ID: Q96G01

Entrez ID: 636

Protein name: Protein bicaudal D homolog 1 (Bic-D 1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for BICD1 in