DegronMD - Q96G01(BICD1)

FUNCTION: Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.

GO - Biological processes (BP): anatomical structure morphogenesis [GO:0009653]; intracellular mRNA localization [GO:0008298]; microtubule anchoring at microtubule organizing center [GO:0072393]; minus-end-directed organelle transport along microtubule [GO:0072385]; negative regulation of phospholipase C-activating G protein-coupl... View more >>

GO - Molecular function (MF): cytoskeletal anchor activity [GO:0008093]; dynactin binding [GO:0034452]; dynein complex binding [GO:0070840]; dynein intermediate chain binding [GO:0045505]; proteinase activated receptor binding [GO:0031871]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267]; structural consti... View more >>

GO - Cellular component (CC): centrosome [GO:0005813]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; secretory vesicle [GO:0099503]; trans-Golgi network [GO:0005802]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R830C	DO228328	BRCA	ICGC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.8301
p.R830C	DO219724	CESC	ICGC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.8301
p.R830C	DO232761	PBCA	ICGC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.8301
p.P828L	DO234357	ESAD	ICGC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.7582
p.P828L	DO41235	UCEC	ICGC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.7582
p.P830L	DO232224	PBCA	ICGC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.7582
p.R830G	DO45412	LUAD	ICGC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.7568
p.R830S	DO37901	SKCM	ICGC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.7427
p.H831L	DO26425	LUSC	ICGC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.7313
p.V829M	TCGA-37-4132	LUSC	TCGA	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.7208
p.V829M	DO26528	LUSC	ICGC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.7208
p.S824N	DO5682	BRCA	ICGC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.7069
p.E464K	TCGA-D3-A5GU	SKCM	TCGA	IQMYDE	LIG_APCC_ABBA_1	459:464	Mutation altering degron motif	0.7022
p.E464K	TCGA-D3-A5GU	SKCM	TCGA	KIQMYDE	LIG_APCC_ABBAyCdc20_2	458:464	Mutation altering degron motif	0.7022
p.E464K	DO47584	SKCM	ICGC	IQMYDE	LIG_APCC_ABBA_1	459:464	Mutation altering degron motif	0.7022
p.E464K	DO47584	SKCM	ICGC	KIQMYDE	LIG_APCC_ABBAyCdc20_2	458:464	Mutation altering degron motif	0.7022
p.E824K	SIDM00027	Kidney Carcinoma	GDSC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.7022
p.E824K	ACH-001192	Bone Cancer	CCLE	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.7022
p.E824K	SK-NEP-1	kidney	COSMIC	EASVTVPTI	DEG_COP1_1	824:832	Mutation altering degron motif	0.7022
p.V930L	DO233909	GACA	ICGC	QPAASVPPQ	DEG_SIAH_1	925:933	Mutation altering degron motif	0.6765

Showing 1 to 20 of 95 entries

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Kaplan plot for BICD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BICD1

UniProt ID: Q96G01

Entrez ID: 636

Protein name: Protein bicaudal D homolog 1 (Bic-D 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BICD1 in