DegronMD

Uniprot ID: Q96G01

Source protein: Protein bicaudal D homolog 1

Source gene: BICD1

Class: DEG_SCF_FBW7_1

Location: 594:601

E3 ligase: FBXW7

DEGRON score: 0.9976

ASA_SCORE: 100.475

COIL: 0.9326

CONS_SCORE: 0.3632

DSS_SCORE: 0.6665

HELIX: 0.0441

FCONS_SCORE: 1.1429

RIG_SCORE: 0.6183

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K596N	TCGA-55-8506	LUAD	TCGA	PTKTPTIS	DEG_SCF_FBW7_1	0.5806
p.K596N	DO45390	LUAD	ICGC	PTKTPTIS	DEG_SCF_FBW7_1	0.5806
p.E591K	TCGA-78-7539	LUAD	TCGA	PTKTPTIS	DEG_SCF_FBW7_1	0.25
p.E591K	DO26210	LUAD	ICGC	PTKTPTIS	DEG_SCF_FBW7_1	0.25
p.T605A	TCGA-AA-3811	COAD	TCGA	PTKTPTIS	DEG_SCF_FBW7_1	0.6667
p.T605A	DO7962	COAD	ICGC	PTKTPTIS	DEG_SCF_FBW7_1	0.6667
p.P602S	TCGA-BF-AAP1	SKCM	TCGA	PTKTPTIS	DEG_SCF_FBW7_1	0.3056
p.P602S	DO219464	SKCM	ICGC	PTKTPTIS	DEG_SCF_FBW7_1	0.3056
p.S609T	TCGA-D6-A6EK	HNSC	TCGA	PTKTPTIS	DEG_SCF_FBW7_1	0.1111
p.S609T	DO52080	HNSC	ICGC	PTKTPTIS	DEG_SCF_FBW7_1	0.1111
p.V603A	DO222798	COCA	ICGC	PTKTPTIS	DEG_SCF_FBW7_1	0.2778
p.A606S	DO229031	LICA	ICGC	PTKTPTIS	DEG_SCF_FBW7_1	0.1944
p.T605I	SIDM00683	Prostate Carcinoma	GDSC	PTKTPTIS	DEG_SCF_FBW7_1	0.6667
p.T605I	LNCaP-Clone-FGC	prostate	COSMIC	PTKTPTIS	DEG_SCF_FBW7_1	0.6667
p.I600M	SIDM00861	Ovarian Carcinoma	GDSC	PTKTPTIS	DEG_SCF_FBW7_1	0.6507
p.I600M	ACH-000906	Ovarian Cancer	CCLE	PTKTPTIS	DEG_SCF_FBW7_1	0.6507
p.I600M	ES-2	ovary	COSMIC	PTKTPTIS	DEG_SCF_FBW7_1	0.6507

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96G01	Protein bicaudal D homolog 1	DEG_SCF_FBW7_1	594:601	PTKTPTIS	FBXW7	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons