DegronMD

Uniprot ID: Q96G01

Source protein: Protein bicaudal D homolog 1

Source gene: BICD1

Class: DEG_COP1_1

Location: 824:832

E3 ligase: COP1

DEGRON score: 0.9174

ASA_SCORE: 96.7

COIL: 0.9413

CONS_SCORE: 0.218

DSS_SCORE: 0.4513

HELIX: 0.0259

FCONS_SCORE: 0.8322

RIG_SCORE: 0.7358

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V829M	TCGA-37-4132	LUSC	TCGA	EASVTVPTI	DEG_COP1_1	0.7208
p.V829M	DO26528	LUSC	ICGC	EASVTVPTI	DEG_COP1_1	0.7208
p.P842Q	TCGA-CN-6010	HNSC	TCGA	EASVTVPTI	DEG_COP1_1	0.0556
p.P842Q	DO14766	HNSC	ICGC	EASVTVPTI	DEG_COP1_1	0.0556
p.R830C	DO228328	BRCA	ICGC	EASVTVPTI	DEG_COP1_1	0.8301
p.R830C	DO219724	CESC	ICGC	EASVTVPTI	DEG_COP1_1	0.8301
p.R830C	DO232761	PBCA	ICGC	EASVTVPTI	DEG_COP1_1	0.8301
p.S824N	DO5682	BRCA	ICGC	EASVTVPTI	DEG_COP1_1	0.7069
p.P828L	DO234357	ESAD	ICGC	EASVTVPTI	DEG_COP1_1	0.7582
p.P828L	DO41235	UCEC	ICGC	EASVTVPTI	DEG_COP1_1	0.7582
p.R830G	DO45412	LUAD	ICGC	EASVTVPTI	DEG_COP1_1	0.7568
p.H831L	DO26425	LUSC	ICGC	EASVTVPTI	DEG_COP1_1	0.7313
p.P830L	DO232224	PBCA	ICGC	EASVTVPTI	DEG_COP1_1	0.7582
p.R830S	DO37901	SKCM	ICGC	EASVTVPTI	DEG_COP1_1	0.7427
p.V827D	SIDM00845	Burkitt's Lymphoma	GDSC	EASVTVPTI	DEG_COP1_1	0.6674
p.V827D	ACH-000786	Lymphoma	CCLE	EASVTVPTI	DEG_COP1_1	0.6674
p.V827D	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	EASVTVPTI	DEG_COP1_1	0.6674
p.E824K	SIDM00027	Kidney Carcinoma	GDSC	EASVTVPTI	DEG_COP1_1	0.7022
p.E824K	ACH-001192	Bone Cancer	CCLE	EASVTVPTI	DEG_COP1_1	0.7022
p.E824K	SK-NEP-1	kidney	COSMIC	EASVTVPTI	DEG_COP1_1	0.7022
p.S814T	SIDM00929	Chondrosarcoma	GDSC	EASVTVPTI	DEG_COP1_1	0.0556
p.S814T	ACH-000516	Bone Cancer	CCLE	EASVTVPTI	DEG_COP1_1	0.0556
p.S814T	CAL-78	bone	COSMIC	EASVTVPTI	DEG_COP1_1	0.0556
p.S826P	ACH-000786	Lymphoma	CCLE	EASVTVPTI	DEG_COP1_1	0.6752
p.S826P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	EASVTVPTI	DEG_COP1_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96G01	Protein bicaudal D homolog 1	DEG_COP1_1	824:832	EASVTVPTI	COP1	0.9174	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons