DegronMD

Uniprot ID: Q96G01

Source protein: Protein bicaudal D homolog 1

Source gene: BICD1

Class: DEG_SIAH_1

Location: 925:933

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9425

ASA_SCORE: 73.4111

COIL: 0.9072

CONS_SCORE: 0.2437

DSS_SCORE: 0.53

HELIX: 0.0558

FCONS_SCORE: 1.0406

RIG_SCORE: 0.6615

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P931R	TCGA-55-8507	LUAD	TCGA	QPAASVPPQ	DEG_SIAH_1	0.6401
p.G939R	TCGA-C5-A7UC	CESC	TCGA	QPAASVPPQ	DEG_SIAH_1	0.1667
p.G939R	TCGA-W3-AA1O	SKCM	TCGA	QPAASVPPQ	DEG_SIAH_1	0.1667
p.G939R	DO49889	CESC	ICGC	QPAASVPPQ	DEG_SIAH_1	0.1667
p.G939R	DO51274	SKCM	ICGC	QPAASVPPQ	DEG_SIAH_1	0.1667
p.P931Q	TCGA-D3-A2J6	SKCM	TCGA	QPAASVPPQ	DEG_SIAH_1	0.5924
p.P920S	TCGA-EE-A2M5	SKCM	TCGA	QPAASVPPQ	DEG_SIAH_1	0.1944
p.P920S	DO222423	MELA	ICGC	QPAASVPPQ	DEG_SIAH_1	0.1944
p.P920S	DO37425	SKCM	ICGC	QPAASVPPQ	DEG_SIAH_1	0.1944
p.A938V	TCGA-EE-A3J5	SKCM	TCGA	QPAASVPPQ	DEG_SIAH_1	0.1944
p.A938V	DO47331	SKCM	ICGC	QPAASVPPQ	DEG_SIAH_1	0.1944
p.D922Y	TCGA-G7-6797	KIRP	TCGA	QPAASVPPQ	DEG_SIAH_1	0.25
p.D922Y	DO20917	KIRP	ICGC	QPAASVPPQ	DEG_SIAH_1	0.25
p.T917A	TCGA-HU-8602	STAD	TCGA	QPAASVPPQ	DEG_SIAH_1	0.1111
p.T917A	DO47829	STAD	ICGC	QPAASVPPQ	DEG_SIAH_1	0.1111
p.P931L	TCGA-MA-AA42	CESC	TCGA	QPAASVPPQ	DEG_SIAH_1	0.6471
p.G939E	TCGA-W3-AA1O	SKCM	TCGA	QPAASVPPQ	DEG_SIAH_1	0.1667
p.G939E	DO51274	SKCM	ICGC	QPAASVPPQ	DEG_SIAH_1	0.1667
p.V918L	TCGA-ZP-A9D1	LIHC	TCGA	QPAASVPPQ	DEG_SIAH_1	0.1389
p.V918L	DO52332	LIHC	ICGC	QPAASVPPQ	DEG_SIAH_1	0.1389
p.V930L	DO233909	GACA	ICGC	QPAASVPPQ	DEG_SIAH_1	0.6765
p.D942Y	DO231204	LUSC	ICGC	QPAASVPPQ	DEG_SIAH_1	0.0833
p.A927V	SIDM02015	Colorectal Carcinoma	GDSC	QPAASVPPQ	DEG_SIAH_1	0.5825
p.C943Y	SIDM00845	Burkitt's Lymphoma	GDSC	QPAASVPPQ	DEG_SIAH_1	0.0556
p.V918M	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	QPAASVPPQ	DEG_SIAH_1	0.1389
p.V918M	EBC-1	lung	COSMIC	QPAASVPPQ	DEG_SIAH_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96G01	Protein bicaudal D homolog 1	DEG_SIAH_1	925:933	QPAASVPPQ	SIAH1,SIAH2,SIAH3	0.9425	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons