DegronMD

Uniprot ID: Q96G01

Source protein: Protein bicaudal D homolog 1

Source gene: BICD1

Class: LIG_APCC_ABBA_1

Location: 459:464

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8664

ASA_SCORE: 105.4333

COIL: 0.0547

CONS_SCORE: 0.3556

DSS_SCORE: 0.3967

HELIX: 0.9468

FCONS_SCORE: 0.9961

RIG_SCORE: 0.7903

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L469I	TCGA-D3-A2JC	SKCM	TCGA	IQMYDE	LIG_APCC_ABBA_1	0.1944
p.L469I	DO47578	SKCM	ICGC	IQMYDE	LIG_APCC_ABBA_1	0.1944
p.E464K	TCGA-D3-A5GU	SKCM	TCGA	IQMYDE	LIG_APCC_ABBA_1	0.7022
p.E464K	DO47584	SKCM	ICGC	IQMYDE	LIG_APCC_ABBA_1	0.7022
p.E470Q	TCGA-DK-A2I4	BLCA	TCGA	IQMYDE	LIG_APCC_ABBA_1	0.1667
p.E470Q	DO465	BLCA	ICGC	IQMYDE	LIG_APCC_ABBA_1	0.1667
p.T473A	DO222884	COCA	ICGC	IQMYDE	LIG_APCC_ABBA_1	0.0833
p.T467I	SIDM02039	Colorectal Carcinoma	GDSC	IQMYDE	LIG_APCC_ABBA_1	0.25
p.T467A	ACH-000937	Leukemia	CCLE	IQMYDE	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96G01	Protein bicaudal D homolog 1	LIG_APCC_ABBA_1	459:464	IQMYDE	APC,CDC20,FZR1	0.8664	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons