DegronMD - O94933(SLITRK3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A291P	TCGA-05-4427	LUAD	TCGA	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.1944
p.A291P	DO23666	LUAD	ICGC	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.1944
p.P358S	TCGA-18-4083	LUSC	TCGA	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation rewiring degron network	0.2778
p.P358S	TCGA-18-4083	LUSC	TCGA	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.0556
p.P358S	DO26504	LUSC	ICGC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation rewiring degron network	0.2778
p.P358S	DO26504	LUSC	ICGC	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.0556
p.L791I	TCGA-35-4122	LUAD	TCGA	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation rewiring degron network	0.0556
p.L791I	DO23782	LUAD	ICGC	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation rewiring degron network	0.0556
p.P310S	TCGA-3R-A8YX	SARC	TCGA	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.0556
p.P310S	DO219943	SARC	ICGC	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.0556
p.G376V	TCGA-43-A56U	LUSC	TCGA	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation rewiring degron network	0.1944
p.G376V	DO49083	LUSC	ICGC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation rewiring degron network	0.1944
p.R340G	TCGA-55-8507	LUAD	TCGA	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2222
p.R340G	DO45412	LUAD	ICGC	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2222
p.R340G	SIDM01146	Gastric Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2222
p.R340G	ACH-000932	Gastric Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2222
p.R340G	NCI-SNU-1	stomach	COSMIC	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2222
p.G376E	TCGA-60-2720	LUSC	TCGA	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation rewiring degron network	0.1944
p.G376E	DO26587	LUSC	ICGC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation rewiring degron network	0.1944
p.R340L	TCGA-60-2725	LUSC	TCGA	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2222
p.R340L	DO26674	LUSC	ICGC	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2222
p.S299T	TCGA-78-7161	LUAD	TCGA	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation altering degron motif	0.6005
p.S299T	DO25975	LUAD	ICGC	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation altering degron motif	0.6005
p.Y352C	TCGA-96-7545	LUSC	TCGA	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation rewiring degron network	0.1111
p.Y352C	TCGA-96-7545	LUSC	TCGA	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2222
p.Y352C	DO26492	LUSC	ICGC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation rewiring degron network	0.1111
p.Y352C	DO26492	LUSC	ICGC	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2222
p.C373G	TCGA-99-8025	LUAD	TCGA	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation rewiring degron network	0.2778
p.C373G	DO24255	LUAD	ICGC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation rewiring degron network	0.2778
p.R343M	TCGA-A5-A0G2	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.3056
p.R343M	TCGA-EO-A22U	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.3056
p.R343M	DO41235	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.3056
p.R343M	DO43755	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.3056
p.E303D	TCGA-A5-A0G2	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.25
p.E303D	DO41235	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.25
p.S298L	TCGA-AA-A00N	COAD	TCGA	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation altering degron motif	0.7667
p.S298L	TCGA-AA-A010	COAD	TCGA	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation altering degron motif	0.7667
p.S298L	TCGA-D3-A8GB	SKCM	TCGA	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation altering degron motif	0.7667
p.S298L	TCGA-EE-A29M	SKCM	TCGA	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation altering degron motif	0.7667
p.S298L	DO9876	COAD	ICGC	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation altering degron motif	0.7667
p.S298L	DO222762	COCA	ICGC	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation altering degron motif	0.7667
p.S298L	DO222837	MELA	ICGC	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation altering degron motif	0.7667
p.S298L	DO37404	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation altering degron motif	0.7667
p.S298L	DO50280	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation altering degron motif	0.7667
p.L812Q	TCGA-AD-6901	COAD	TCGA	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation rewiring degron network	0.1389
p.L812Q	DO9218	COAD	ICGC	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation rewiring degron network	0.1389
p.R340Q	TCGA-AP-A056	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2222
p.R340Q	TCGA-CN-A6V3	HNSC	TCGA	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2222
p.R340Q	TCGA-GF-A6C9	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2222
p.R340Q	DO52050	HNSC	ICGC	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2222
p.R340Q	DO51254	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2222
p.R340Q	DO43971	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2222
p.A798V	TCGA-AP-A1DK	UCEC	TCGA	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation rewiring degron network	0.25
p.A798V	DO42033	UCEC	ICGC	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation rewiring degron network	0.25
p.P359H	TCGA-D1-A2G0	UCEC	TCGA	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation rewiring degron network	0.3056
p.P359H	DO43049	UCEC	ICGC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation rewiring degron network	0.3056
p.I295F	TCGA-DA-A1HV	SKCM	TCGA	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.3056
p.I295F	DO37659	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.3056
p.G294E	TCGA-DA-A1HV	SKCM	TCGA	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.2778
p.G294E	DO37659	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.2778
p.S287F	TCGA-EE-A2GD	SKCM	TCGA	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.0833
p.S287F	DO37603	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.0833
p.S287F	SIDM01060	Melanoma	GDSC	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.0833
p.S287F	ACH-000882	Skin Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.0833
p.S287F	IGR-1	skin	COSMIC	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.0833
p.E803D	TCGA-EO-A22U	UCEC	TCGA	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation altering degron motif	0.6758
p.E803D	DO43755	UCEC	ICGC	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation altering degron motif	0.6758
p.S348F	TCGA-ER-A42L	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation altering degron motif	0.7982
p.S348F	DO223910	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation altering degron motif	0.7982
p.G376R	TCGA-EY-A215	UCEC	TCGA	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation rewiring degron network	0.1944
p.G376R	DO42665	UCEC	ICGC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation rewiring degron network	0.1944
p.P345L	TCGA-FI-A2D0	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation altering degron motif	0.6471
p.P345L	DO43891	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation altering degron motif	0.6471
p.L791F	TCGA-FW-A3R5	SKCM	TCGA	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation rewiring degron network	0.0556
p.L791F	DO37406	SKCM	ICGC	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation rewiring degron network	0.0556
p.E288D	TCGA-JY-A6FA	ESCA	TCGA	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.1111
p.S301I	TCGA-ND-A4WC	UCS	TCGA	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.3056
p.E815Q	TCGA-ZF-AA4V	BLCA	TCGA	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation rewiring degron network	0.0556
p.E815Q	DO219087	BLCA	ICGC	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation rewiring degron network	0.0556
p.T810I	DO222404	BTCA	ICGC	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation rewiring degron network	0.1944
p.P358T	DO222404	BTCA	ICGC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation rewiring degron network	0.2778
p.P358T	DO222404	BTCA	ICGC	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.0556
p.E813K	DO6376	CLLE	ICGC	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation rewiring degron network	0.1111
p.L293M	DO234403	ESAD	ICGC	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.25
p.E288K	DO223046	ESCA	ICGC	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.1111
p.K309R	DO228676	GACA	ICGC	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation substituting flanking lysine	0.1944
p.E815V	DO228278	LICA	ICGC	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation rewiring degron network	0.0556
p.Q338K	DO228985	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.1667
p.P342Q	DO229022	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2778
p.T341K	DO229031	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.25
p.KE802KK	DO222753	MELA	ICGC	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation altering degron motif	0.6667
p.K302Q	DO222843	MELA	ICGC	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.2778
p.G376W	DO232061	ORCA	ICGC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation rewiring degron network	0.1944
p.G376W	ACH-000975	Lung Cancer	CCLE	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation rewiring degron network	0.1944
p.P362S	DO218900	SKCA	ICGC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation altering degron motif	0.6752
p.P362S	SIDM01088	Endometrial Carcinoma	GDSC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation altering degron motif	0.6752
p.P362S	ACH-000965	Endometrial/Uterine Cancer	CCLE	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation altering degron motif	0.6752
p.P362S	RL95-2	endometrium	COSMIC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation altering degron motif	0.6752
p.P296L	DO218856	SKCA	ICGC	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation altering degron motif	0.7582
p.L293F	DO220994	WT	ICGC	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.25
p.S346A	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation altering degron motif	0.7588
p.S346A	ACH-000920	Leukemia	CCLE	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation altering degron motif	0.7588
p.P335L	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.0833
p.P335L	Calu-3	lung	COSMIC	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.0833
p.E803K	SIDM00082	Melanoma	GDSC	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation altering degron motif	0.7022
p.E803K	ACH-001190	Skin Cancer	CCLE	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation altering degron motif	0.7022
p.E803K	SK-MEL-2	skin	COSMIC	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation altering degron motif	0.7022
p.Q357K	SIDM00120	Prostate Carcinoma	GDSC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation rewiring degron network	0.25
p.Q357K	SIDM00120	Prostate Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.0833
p.Q357K	SIDM00507	Other Solid Cancers	GDSC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation rewiring degron network	0.25
p.Q357K	SIDM00507	Other Solid Cancers	GDSC	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.0833
p.Q357K	ACH-000979	Prostate Cancer	CCLE	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation rewiring degron network	0.25
p.Q357K	ACH-000979	Prostate Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.0833
p.Q357K	ACH-001490	Lung Cancer	CCLE	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation rewiring degron network	0.25
p.Q357K	ACH-001490	Lung Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.0833
p.Q357K	COR-L321	NS	COSMIC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation rewiring degron network	0.25
p.Q357K	COR-L321	NS	COSMIC	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.0833
p.Q357K	DU-145	prostate	COSMIC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	360:371	Mutation rewiring degron network	0.25
p.Q357K	DU-145	prostate	COSMIC	PPSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.0833
p.A305T	SIDM00965	Small Cell Lung Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.1944
p.A305T	ACH-000800	Lung Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.1944
p.A305T	NCI-H446	lung	COSMIC	PHSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.1944
p.N804I	SIDM00068	Colorectal Carcinoma	GDSC	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation altering degron motif	0.728
p.N804I	ACH-002394	Colon/Colorectal Cancer	CCLE	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation altering degron motif	0.728
p.N804I	GEO	large intestine	COSMIC	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation altering degron motif	0.728
p.L812M	SIDM01693	B-Lymphoblastic Leukemia	GDSC	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation rewiring degron network	0.1389
p.L812M	ACH-000032	Leukemia	CCLE	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation rewiring degron network	0.1389
p.Q796R	SIDM01693	B-Lymphoblastic Leukemia	GDSC	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation rewiring degron network	0.1944
p.Q796R	ACH-000032	Leukemia	CCLE	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation rewiring degron network	0.1944
p.Q796K	SIDM01693	B-Lymphoblastic Leukemia	GDSC	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation rewiring degron network	0.1944
p.Q796K	ACH-000032	Leukemia	CCLE	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation rewiring degron network	0.1944
p.E795K	SIDM01761	Rhabdomyosarcoma	GDSC	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation rewiring degron network	0.1667
p.E795K	ACH-000175	Non-Cancerous	CCLE	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation rewiring degron network	0.1667
p.N804T	SIDM00159	Biliary Tract Carcinoma	GDSC	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation altering degron motif	0.7055
p.N804T	ACH-000182	Bile Duct Cancer	CCLE	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation altering degron motif	0.7055
p.R809W	ACH-001991	Primary	CCLE	PKENH	DEG_APCC_KENBOX_2	801:805	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLITRK3

UniProt ID: O94933

Entrez ID: 22865

Protein name: SLIT and NTRK-like protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLITRK3 in