DegronMD

Uniprot ID: O94933

Source protein: SLIT and NTRK-like protein 3

Source gene: SLITRK3

Class: DEG_ODPH_VHL_1

Location: 360:371

E3 ligase: VHL

DEGRON score: 0.9959

ASA_SCORE: 53.0667

COIL: 0.8317

CONS_SCORE: 0.6886

DSS_SCORE: 0.3996

HELIX: 0.0513

FCONS_SCORE: 1.0275

RIG_SCORE: 0.7303

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P358S	TCGA-18-4083	LUSC	TCGA	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.2778
p.P358S	DO26504	LUSC	ICGC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.2778
p.G376V	TCGA-43-A56U	LUSC	TCGA	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.1944
p.G376V	DO49083	LUSC	ICGC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.1944
p.G376E	TCGA-60-2720	LUSC	TCGA	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.1944
p.G376E	DO26587	LUSC	ICGC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.1944
p.Y352C	TCGA-96-7545	LUSC	TCGA	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.1111
p.Y352C	DO26492	LUSC	ICGC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.1111
p.C373G	TCGA-99-8025	LUAD	TCGA	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.2778
p.C373G	DO24255	LUAD	ICGC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.2778
p.P359H	TCGA-D1-A2G0	UCEC	TCGA	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.3056
p.P359H	DO43049	UCEC	ICGC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.3056
p.G376R	TCGA-EY-A215	UCEC	TCGA	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.1944
p.G376R	DO42665	UCEC	ICGC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.1944
p.P358T	DO222404	BTCA	ICGC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.2778
p.G376W	DO232061	ORCA	ICGC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.1944
p.G376W	ACH-000975	Lung Cancer	CCLE	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.1944
p.P362S	DO218900	SKCA	ICGC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.6752
p.P362S	SIDM01088	Endometrial Carcinoma	GDSC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.6752
p.P362S	ACH-000965	Endometrial/Uterine Cancer	CCLE	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.6752
p.P362S	RL95-2	endometrium	COSMIC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.6752
p.Q357K	SIDM00120	Prostate Carcinoma	GDSC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.25
p.Q357K	SIDM00507	Other Solid Cancers	GDSC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.25
p.Q357K	ACH-000979	Prostate Cancer	CCLE	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.25
p.Q357K	ACH-001490	Lung Cancer	CCLE	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.25
p.Q357K	COR-L321	NS	COSMIC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.25
p.Q357K	DU-145	prostate	COSMIC	IAPYQTRPPIPI	DEG_ODPH_VHL_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPYQTRPPIPI

Degron related mutations and impact score

Drug responses associated with SLITRK3 mutations

All proteins holding degron of IAPYQTRPPIPI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94933	SLIT and NTRK-like protein 3	DEG_ODPH_VHL_1	360:371	IAPYQTRPPIPI	VHL	0.9959	More...