DegronMD

Uniprot ID: O94933

Source protein: SLIT and NTRK-like protein 3

Source gene: SLITRK3

Class: DEG_SPOP_SBC_1

Location: 296:300

E3 ligase: SPOP

DEGRON score: 0.8737

ASA_SCORE: 51.22

COIL: 0.8372

CONS_SCORE: 0.4161

DSS_SCORE: 0.4849

HELIX: 0.0894

FCONS_SCORE: 0.7945

RIG_SCORE: 0.6165

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A291P	TCGA-05-4427	LUAD	TCGA	PHSSS	DEG_SPOP_SBC_1	0.1944
p.A291P	DO23666	LUAD	ICGC	PHSSS	DEG_SPOP_SBC_1	0.1944
p.P310S	TCGA-3R-A8YX	SARC	TCGA	PHSSS	DEG_SPOP_SBC_1	0.0556
p.P310S	DO219943	SARC	ICGC	PHSSS	DEG_SPOP_SBC_1	0.0556
p.S299T	TCGA-78-7161	LUAD	TCGA	PHSSS	DEG_SPOP_SBC_1	0.6005
p.S299T	DO25975	LUAD	ICGC	PHSSS	DEG_SPOP_SBC_1	0.6005
p.E303D	TCGA-A5-A0G2	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	0.25
p.E303D	DO41235	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	0.25
p.S298L	TCGA-AA-A00N	COAD	TCGA	PHSSS	DEG_SPOP_SBC_1	0.7667
p.S298L	TCGA-AA-A010	COAD	TCGA	PHSSS	DEG_SPOP_SBC_1	0.7667
p.S298L	TCGA-D3-A8GB	SKCM	TCGA	PHSSS	DEG_SPOP_SBC_1	0.7667
p.S298L	TCGA-EE-A29M	SKCM	TCGA	PHSSS	DEG_SPOP_SBC_1	0.7667
p.S298L	DO9876	COAD	ICGC	PHSSS	DEG_SPOP_SBC_1	0.7667
p.S298L	DO222762	COCA	ICGC	PHSSS	DEG_SPOP_SBC_1	0.7667
p.S298L	DO222837	MELA	ICGC	PHSSS	DEG_SPOP_SBC_1	0.7667
p.S298L	DO37404	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	0.7667
p.S298L	DO50280	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	0.7667
p.I295F	TCGA-DA-A1HV	SKCM	TCGA	PHSSS	DEG_SPOP_SBC_1	0.3056
p.I295F	DO37659	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	0.3056
p.G294E	TCGA-DA-A1HV	SKCM	TCGA	PHSSS	DEG_SPOP_SBC_1	0.2778
p.G294E	DO37659	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	0.2778
p.S287F	TCGA-EE-A2GD	SKCM	TCGA	PHSSS	DEG_SPOP_SBC_1	0.0833
p.S287F	DO37603	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	0.0833
p.S287F	SIDM01060	Melanoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.0833
p.S287F	ACH-000882	Skin Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	0.0833
p.S287F	IGR-1	skin	COSMIC	PHSSS	DEG_SPOP_SBC_1	0.0833
p.E288D	TCGA-JY-A6FA	ESCA	TCGA	PHSSS	DEG_SPOP_SBC_1	0.1111
p.S301I	TCGA-ND-A4WC	UCS	TCGA	PHSSS	DEG_SPOP_SBC_1	0.3056
p.L293M	DO234403	ESAD	ICGC	PHSSS	DEG_SPOP_SBC_1	0.25
p.E288K	DO223046	ESCA	ICGC	PHSSS	DEG_SPOP_SBC_1	0.1111
p.K309R	DO228676	GACA	ICGC	PHSSS	DEG_SPOP_SBC_1	0.1944
p.K302Q	DO222843	MELA	ICGC	PHSSS	DEG_SPOP_SBC_1	0.2778
p.P296L	DO218856	SKCA	ICGC	PHSSS	DEG_SPOP_SBC_1	0.7582
p.L293F	DO220994	WT	ICGC	PHSSS	DEG_SPOP_SBC_1	0.25
p.A305T	SIDM00965	Small Cell Lung Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.1944
p.A305T	ACH-000800	Lung Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	0.1944
p.A305T	NCI-H446	lung	COSMIC	PHSSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14559	Rho GTPase-activating protein 33	DEG_SPOP_SBC_1	658:662	PHSSS	SPOP	0.9958	More...
O60229	Kalirin	DEG_SPOP_SBC_1	732:736	PHSSS	SPOP	0.9258	More...
O75747	Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma	DEG_SPOP_SBC_1	30:34	PHSSS	SPOP	0.9099	More...
O94933	SLIT and NTRK-like protein 3	DEG_SPOP_SBC_1	296:300	PHSSS	SPOP	0.8737	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	3950:3954	PHSSS	SPOP	0.969	More...
P29372	DNA-3-methyladenine glycosylase	DEG_SPOP_SBC_1	45:49	PHSSS	SPOP	0.9962	More...
P48436	Transcription factor SOX-9	DEG_SPOP_SBC_1	212:216	PHSSS	SPOP	0.9783	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4662:4666	PHSSS	SPOP	0.7998	More...
Q13129	Zinc finger protein Rlf	DEG_SPOP_SBC_1	1828:1832	PHSSS	SPOP	0.9974	More...
Q14C86	GTPase-activating protein and VPS9 domain-containing protein 1	DEG_SPOP_SBC_1	944:948	PHSSS	SPOP	0.9376	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	304:308	PHSSS	SPOP	0.9956	More...
Q76I76	Protein phosphatase Slingshot homolog 2	DEG_SPOP_SBC_1	1079:1083	PHSSS	SPOP	0.7902	More...
Q76I76	Protein phosphatase Slingshot homolog 2	DEG_SPOP_SBC_1	1213:1217	PHSSS	SPOP	0.9976	More...
Q8IYI8	Zinc finger protein 440	DEG_SPOP_SBC_1	378:382	PHSSS	SPOP	0.7442	More...
Q8NEL9	Phospholipase DDHD1	DEG_SPOP_SBC_1	802:806	PHSSS	SPOP	0.812	More...
Q8TDJ6	DmX-like protein 2	DEG_SPOP_SBC_1	956:960	PHSSS	SPOP	0.985	More...
Q96G01	Protein bicaudal D homolog 1	DEG_SPOP_SBC_1	957:961	PHSSS	SPOP	0.9246	More...
Q9C0B5	Palmitoyltransferase ZDHHC5	DEG_SPOP_SBC_1	368:372	PHSSS	SPOP	0.9986	More...
Q9HCH0	Nck-associated protein 5-like	DEG_SPOP_SBC_1	424:428	PHSSS	SPOP	0.8761	More...
Q9UIF9	Bromodomain adjacent to zinc finger domain protein 2A	DEG_SPOP_SBC_1	74:78	PHSSS	SPOP	0.969	More...
Q5VYM1	Uncharacterized protein C9orf131	DEG_SPOP_SBC_1	840:844	PHSSS	SPOP	0.8857	More...
Q9P1A2	Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like	DEG_SPOP_SBC_1	345:349	PHSSS	SPOP	0.5244	More...
Q9H6K5	Proline-rich protein 36	DEG_SPOP_SBC_1	357:361	PHSSS	SPOP	0.9525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PHSSS

Degron related mutations and impact score

Drug responses associated with SLITRK3 mutations

All proteins holding degron of PHSSS