DegronMD - Q68DE3(USF3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I303N	SIDM02015	Colorectal Carcinoma	GDSC	MTPCVT	DEG_SCF_FBW7_1	296:301	Mutation rewiring degron network	0.2778
p.I303N	SIDM02015	Colorectal Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.3056
p.D1085N	SIDM02021	Esophageal Carcinoma	GDSC	PMSTS	DEG_SPOP_SBC_1	1087:1091	Mutation rewiring degron network	0.2778
p.S679P	SIDM00321	Ovarian Carcinoma	GDSC	VMSSS	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.6752
p.S679P	TYK-nu	ovary	COSMIC	VMSSS	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.6752
p.I1906T	SIDM00338	Acute Myeloid Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	1896:1900	Mutation rewiring degron network	0.1667
p.I1906T	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	1896:1900	Mutation rewiring degron network	0.1667
p.I1906T	SIDM00562	Breast Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	1896:1900	Mutation rewiring degron network	0.1667
p.I1906T	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	1896:1900	Mutation rewiring degron network	0.1667
p.I1906T	SIDM00365	Small Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	1896:1900	Mutation rewiring degron network	0.1667
p.I1906T	SIDM00576	Acute Myeloid Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	1896:1900	Mutation rewiring degron network	0.1667
p.I1906T	SIDM00574	Glioblastoma	GDSC	PFSSS	DEG_SPOP_SBC_1	1896:1900	Mutation rewiring degron network	0.1667
p.I1906T	SIDM00469	Pancreatic Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	1896:1900	Mutation rewiring degron network	0.1667
p.I1906T	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	1896:1900	Mutation rewiring degron network	0.1667
p.I1906T	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	1896:1900	Mutation rewiring degron network	0.1667
p.I1906T	SIDM01588	Endometrial Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	1896:1900	Mutation rewiring degron network	0.1667
p.I1906T	SIDM01473	Plasma Cell Myeloma	GDSC	PFSSS	DEG_SPOP_SBC_1	1896:1900	Mutation rewiring degron network	0.1667
p.I1906T	ME-1	haematopoietic and lymphoid tissue	COSMIC	PFSSS	DEG_SPOP_SBC_1	1896:1900	Mutation rewiring degron network	0.1667
p.N607S	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	SNNSVQNVPTP	DEG_COP1_1	615:625	Mutation rewiring degron network	0.1111
p.N607S	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	SNNSVQNVPTP	DEG_COP1_1	615:625	Mutation rewiring degron network	0.1111
p.T686S	SIDM00845	Burkitt's Lymphoma	GDSC	VMSSS	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.1667
p.T686S	SIDM00035	Thyroid Gland Carcinoma	GDSC	VMSSS	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.1667
p.T686S	SIDM00461	Acute Myeloid Leukemia	GDSC	VMSSS	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.1667
p.T686S	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VMSSS	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.1667
p.T686S	SIDM01519	Head and Neck Carcinoma	GDSC	VMSSS	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.1667
p.V1277I	SIDM00602	Gastric Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	1277:1281	Mutation altering degron motif	0.7076
p.V1277I	IM-95	stomach	COSMIC	VSSSS	DEG_SPOP_SBC_1	1277:1281	Mutation altering degron motif	0.7076
p.N573S	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	PSTTPCPT	DEG_SCF_FBW7_1	558:565	Mutation rewiring degron network	0.1111
p.N573S	HOP-92	lung	COSMIC	PSTTPCPT	DEG_SCF_FBW7_1	558:565	Mutation rewiring degron network	0.1111
p.Q1478H	SIDM00487	Colorectal Carcinoma	GDSC	ERHHLYQMQ	DEG_APCC_DBOX_1	1484:1492	Mutation rewiring degron network	0.1667
p.R1096H	SIDM00150	Colorectal Carcinoma	GDSC	PMSTS	DEG_SPOP_SBC_1	1087:1091	Mutation rewiring degron network	0.1944
p.R1096H	KM12	large intestine	COSMIC	PMSTS	DEG_SPOP_SBC_1	1087:1091	Mutation rewiring degron network	0.1944
p.P562L	SIDM00515	Melanoma	GDSC	PSTTPCPT	DEG_SCF_FBW7_1	558:565	Mutation altering degron motif	0.7582
p.P562L	COLO-800	skin	COSMIC	PSTTPCPT	DEG_SCF_FBW7_1	558:565	Mutation altering degron motif	0.7582
p.L1291V	SIDM01472	Hepatocellular Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	1277:1281	Mutation rewiring degron network	0.0556
p.A309V	SIDM01472	Hepatocellular Carcinoma	GDSC	MTPCVT	DEG_SCF_FBW7_1	296:301	Mutation rewiring degron network	0.1111
p.A309V	SIDM01472	Hepatocellular Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.3056
p.V300I	SIDM01619	Endometrial Carcinoma	GDSC	MTPCVT	DEG_SCF_FBW7_1	296:301	Mutation altering degron motif	0.5965

Kaplan plot for USF3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USF3

UniProt ID: Q68DE3

Entrez ID: 205717

Protein name: Basic helix-loop-helix domain-containing protein USF3 (Upstream transcription factor 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USF3 in