DegronMD

Uniprot ID: Q68DE3

Source protein: Basic helix-loop-helix domain-containing protein USF3

Source gene: USF3

Class: DEG_SCF_FBW7_1

Location: 296:301

E3 ligase: FBXW7

DEGRON score: 0.9889

ASA_SCORE: 101.4667

COIL: 0.9403

CONS_SCORE: 0.4471

DSS_SCORE: 0.5201

HELIX: 0.0117

FCONS_SCORE: 1.0699

RIG_SCORE: 0.7411

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V300I	SIDM01619	Endometrial Carcinoma	GDSC	MTPCVT	DEG_SCF_FBW7_1	0.5965
p.I303N	SIDM02015	Colorectal Carcinoma	GDSC	MTPCVT	DEG_SCF_FBW7_1	0.2778
p.A309V	SIDM01472	Hepatocellular Carcinoma	GDSC	MTPCVT	DEG_SCF_FBW7_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SCF_FBW7_1	296:301	MTPCVT	FBXW7	0.9889	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons