DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
ERHHLYQMQ
Uniprot ID:
Q68DE3
Source protein:
Basic helix-loop-helix domain-containing protein USF3
Source gene:
USF3
Class:
DEG_APCC_DBOX_1
Location:
1484:1492
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8795
ASA_SCORE:
118.6889
COIL:
0.4847
CONS_SCORE:
0.6789
DSS_SCORE:
0.7827
HELIX:
0.4711
FCONS_SCORE:
1.0712
RIG_SCORE:
0.6261
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q1478H
SIDM00487
Colorectal Carcinoma
GDSC
ERHHLYQMQ
DEG_APCC_DBOX_1
0.1667
Drug responses associated with USF3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ERHHLYQMQ
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q68DE3
Basic helix-loop-helix domain-containing protein USF3
DEG_APCC_DBOX_1
1484:1492
ERHHLYQMQ
APC,CDC20,FZR1
0.8795
More...