DegronMD

Uniprot ID: Q68DE3

Source protein: Basic helix-loop-helix domain-containing protein USF3

Source gene: USF3

Class: DEG_SPOP_SBC_1

Location: 676:680

E3 ligase: SPOP

DEGRON score: 0.9741

ASA_SCORE: 98.28

COIL: 0.9444

CONS_SCORE: 0.5605

DSS_SCORE: 0.534

HELIX: 0.014

FCONS_SCORE: 0.7957

RIG_SCORE: 0.6558

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S679P	SIDM00321	Ovarian Carcinoma	GDSC	VMSSS	DEG_SPOP_SBC_1	0.6752
p.S679P	TYK-nu	ovary	COSMIC	VMSSS	DEG_SPOP_SBC_1	0.6752
p.T686S	SIDM00845	Burkitt's Lymphoma	GDSC	VMSSS	DEG_SPOP_SBC_1	0.1667
p.T686S	SIDM00035	Thyroid Gland Carcinoma	GDSC	VMSSS	DEG_SPOP_SBC_1	0.1667
p.T686S	SIDM00461	Acute Myeloid Leukemia	GDSC	VMSSS	DEG_SPOP_SBC_1	0.1667
p.T686S	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VMSSS	DEG_SPOP_SBC_1	0.1667
p.T686S	SIDM01519	Head and Neck Carcinoma	GDSC	VMSSS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49848	Transcription initiation factor TFIID subunit 6	DEG_SPOP_SBC_1	540:544	VMSSS	SPOP	0.9875	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	676:680	VMSSS	SPOP	0.9741	More...
Q8NF50	Dedicator of cytokinesis protein 8	DEG_SPOP_SBC_1	900:904	VMSSS	SPOP	0.99	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	239:243	VMSSS	SPOP	0.5358	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons