DegronMD

Uniprot ID: Q8NF50

Source protein: Dedicator of cytokinesis protein 8

Source gene: DOCK8

Class: DEG_SPOP_SBC_1

Location: 900:904

E3 ligase: SPOP

DEGRON score: 0.99

ASA_SCORE: 64.1

COIL: 0.5694

CONS_SCORE: 0.2836

DSS_SCORE: 0.4489

HELIX: 0.3926

FCONS_SCORE: 1.0597

RIG_SCORE: 0.6779

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S893T	TCGA-52-7809	LUSC	TCGA	VMSSS	DEG_SPOP_SBC_1	0.1389
p.M901V	TCGA-AX-A05Y	UCEC	TCGA	VMSSS	DEG_SPOP_SBC_1	0.6097
p.D907Y	TCGA-AZ-6598	COAD	TCGA	VMSSS	DEG_SPOP_SBC_1	0.25
p.D907N	TCGA-BF-A1Q0	SKCM	TCGA	VMSSS	DEG_SPOP_SBC_1	0.25
p.H912N	TCGA-CG-5721	STAD	TCGA	VMSSS	DEG_SPOP_SBC_1	0.1111
p.A909T	TCGA-CV-7413	HNSC	TCGA	VMSSS	DEG_SPOP_SBC_1	0.1944
p.R899Q	TCGA-EY-A215	UCEC	TCGA	VMSSS	DEG_SPOP_SBC_1	0.3056
p.A909V	TCGA-EY-A549	UCEC	TCGA	VMSSS	DEG_SPOP_SBC_1	0.1944
p.S913Y	TCGA-FS-A1Z0	SKCM	TCGA	VMSSS	DEG_SPOP_SBC_1	0.0833
p.R908W	DO1015	BRCA	ICGC	VMSSS	DEG_SPOP_SBC_1	0.2222
p.R908W	DO218861	SKCA	ICGC	VMSSS	DEG_SPOP_SBC_1	0.2222
p.M894I	DO229018	LICA	ICGC	VMSSS	DEG_SPOP_SBC_1	0.6111
p.A895S	DO229038	LICA	ICGC	VMSSS	DEG_SPOP_SBC_1	0.1944
p.H899D	DO48478	LIHC	ICGC	VMSSS	DEG_SPOP_SBC_1	0.3056
p.M901T	DO23915	LUAD	ICGC	VMSSS	DEG_SPOP_SBC_1	0.6312
p.R911H	DO49460	PACA	ICGC	VMSSS	DEG_SPOP_SBC_1	0.1389
p.V898I	DO41331	UCEC	ICGC	VMSSS	DEG_SPOP_SBC_1	0.2778
p.D914N	ACH-001669	Leukemia	CCLE	VMSSS	DEG_SPOP_SBC_1	0.0556
p.L905M	CW-2	large_intestine	COSMIC	VMSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49848	Transcription initiation factor TFIID subunit 6	DEG_SPOP_SBC_1	540:544	VMSSS	SPOP	0.9875	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	676:680	VMSSS	SPOP	0.9741	More...
Q8NF50	Dedicator of cytokinesis protein 8	DEG_SPOP_SBC_1	900:904	VMSSS	SPOP	0.99	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	239:243	VMSSS	SPOP	0.5358	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons