DegronMD - P49848(TAF6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P547H	TCGA-79-5596	LUSC	TCGA	VMSSS	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.25
p.R539H	TCGA-B5-A3FC	UCEC	TCGA	VMSSS	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.3056
p.R539H	DO41871	UCEC	ICGC	VMSSS	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.3056
p.P553S	TCGA-CR-6484	HNSC	TCGA	VMSSS	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.0833
p.P553S	DO15206	HNSC	ICGC	VMSSS	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.0833
p.P572Q	TCGA-DX-AB2G	SARC	TCGA	TTSPVTTTVPSV	DEG_COP1_1	567:578	Mutation altering degron motif	0.7035
p.P572Q	TCGA-DX-AB2G	SARC	TCGA	PVTTT	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.7035
p.R561L	TCGA-ER-A19P	SKCM	TCGA	TTSPVTTTVPSV	DEG_COP1_1	567:578	Mutation rewiring degron network	0.1667
p.R561L	TCGA-ER-A19P	SKCM	TCGA	PVTTT	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.0833
p.P571S	TCGA-K4-A54R	BLCA	TCGA	TTSPVTTTVPSV	DEG_COP1_1	567:578	Mutation altering degron motif	0.6752
p.P571S	TCGA-K4-A54R	BLCA	TCGA	PVTTT	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.6752
p.P571S	DO48611	BLCA	ICGC	TTSPVTTTVPSV	DEG_COP1_1	567:578	Mutation altering degron motif	0.6752
p.P571S	DO48611	BLCA	ICGC	PVTTT	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.6752
p.R539C	TCGA-QQ-A8VF	SARC	TCGA	VMSSS	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.3056
p.P566L	TCGA-XF-A9SK	BLCA	TCGA	TTSPVTTTVPSV	DEG_COP1_1	567:578	Mutation rewiring degron network	0.3056
p.P566L	TCGA-XF-A9SK	BLCA	TCGA	PVTTT	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.2222
p.G562S	DO223732	CESC	ICGC	TTSPVTTTVPSV	DEG_COP1_1	567:578	Mutation rewiring degron network	0.1944
p.G562S	DO223732	CESC	ICGC	PVTTT	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.1111
p.T587A	DO44440	HNSC	ICGC	TTSPVTTTVPSV	DEG_COP1_1	567:578	Mutation rewiring degron network	0.0833
p.P548Q	DO228948	LICA	ICGC	VMSSS	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.2222
p.P580H	DO229027	LICA	ICGC	TTSPVTTTVPSV	DEG_COP1_1	567:578	Mutation rewiring degron network	0.2778
p.P580H	DO229027	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.1667
p.S557R	DO229006	LICA	ICGC	TTSPVTTTVPSV	DEG_COP1_1	567:578	Mutation rewiring degron network	0.0556
p.V582I	DO23782	LUAD	ICGC	TTSPVTTTVPSV	DEG_COP1_1	567:578	Mutation rewiring degron network	0.2222
p.V582I	DO23782	LUAD	ICGC	PVTTT	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.1111
p.V540I	DO33043	PACA	ICGC	VMSSS	DEG_SPOP_SBC_1	540:544	Mutation altering degron motif	0.7076
p.P535Q	DO220077	SARC	ICGC	VMSSS	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.1944
p.P576H	DO37966	SKCM	ICGC	TTSPVTTTVPSV	DEG_COP1_1	567:578	Mutation altering degron motif	0.7694
p.G537D	DO229229	THCA	ICGC	VMSSS	DEG_SPOP_SBC_1	540:544	Mutation substituting flanking lysine	0.3611
p.V578M	DO43755	UCEC	ICGC	TTSPVTTTVPSV	DEG_COP1_1	567:578	Mutation altering degron motif	0.6097
p.A551T	SIDM00124	Kidney Carcinoma	GDSC	VMSSS	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.1389
p.A551T	A498	kidney	COSMIC	VMSSS	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.1389
p.P534A	ACH-000818	Breast Cancer	CCLE	VMSSS	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.1667
p.S546R	ACH-000964	Leukemia	CCLE	VMSSS	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.2778
p.S543L	ACH-000964	Leukemia	CCLE	VMSSS	DEG_SPOP_SBC_1	540:544	Mutation altering degron motif	0.7667
p.A571T	A498	kidney	COSMIC	TTSPVTTTVPSV	DEG_COP1_1	567:578	Mutation altering degron motif	0.7139
p.A571T	A498	kidney	COSMIC	PVTTT	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.7139

Kaplan plot for TAF6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TAF6

UniProt ID: P49848

Entrez ID: 6878

Protein name: Transcription initiation factor TFIID subunit 6 (RNA polymerase II TBP-associated factor subunit E) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII70) (Transcription initiation factor TFIID 80 kDa subunit) (TAF(II)80) (TAFII-80) (TAFII80)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TAF6 in