DegronMD

Uniprot ID: P49848

Source protein: Transcription initiation factor TFIID subunit 6

Source gene: TAF6

Class: DEG_COP1_1

Location: 567:578

E3 ligase: COP1

DEGRON score: 0.8312

ASA_SCORE: 90.175

COIL: 0.9272

CONS_SCORE: 0.364

DSS_SCORE: 0.5078

HELIX: 0.0112

FCONS_SCORE: 0.9677

RIG_SCORE: 0.7067

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P572Q	TCGA-DX-AB2G	SARC	TCGA	TTSPVTTTVPSV	DEG_COP1_1	0.7035
p.R561L	TCGA-ER-A19P	SKCM	TCGA	TTSPVTTTVPSV	DEG_COP1_1	0.1667
p.P571S	TCGA-K4-A54R	BLCA	TCGA	TTSPVTTTVPSV	DEG_COP1_1	0.6752
p.P571S	DO48611	BLCA	ICGC	TTSPVTTTVPSV	DEG_COP1_1	0.6752
p.P566L	TCGA-XF-A9SK	BLCA	TCGA	TTSPVTTTVPSV	DEG_COP1_1	0.3056
p.G562S	DO223732	CESC	ICGC	TTSPVTTTVPSV	DEG_COP1_1	0.1944
p.T587A	DO44440	HNSC	ICGC	TTSPVTTTVPSV	DEG_COP1_1	0.0833
p.P580H	DO229027	LICA	ICGC	TTSPVTTTVPSV	DEG_COP1_1	0.2778
p.S557R	DO229006	LICA	ICGC	TTSPVTTTVPSV	DEG_COP1_1	0.0556
p.V582I	DO23782	LUAD	ICGC	TTSPVTTTVPSV	DEG_COP1_1	0.2222
p.P576H	DO37966	SKCM	ICGC	TTSPVTTTVPSV	DEG_COP1_1	0.7694
p.V578M	DO43755	UCEC	ICGC	TTSPVTTTVPSV	DEG_COP1_1	0.6097
p.A571T	A498	kidney	COSMIC	TTSPVTTTVPSV	DEG_COP1_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49848	Transcription initiation factor TFIID subunit 6	DEG_COP1_1	567:578	TTSPVTTTVPSV	COP1	0.8312	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons