DegronMD

Uniprot ID: P49848

Source protein: Transcription initiation factor TFIID subunit 6

Source gene: TAF6

Class: DEG_SPOP_SBC_1

Location: 540:544

E3 ligase: SPOP

DEGRON score: 0.9875

ASA_SCORE: 79.02

COIL: 0.7788

CONS_SCORE: 0.3567

DSS_SCORE: 0.586

HELIX: 0.013

FCONS_SCORE: 0.9805

RIG_SCORE: 0.6605

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P547H	TCGA-79-5596	LUSC	TCGA	VMSSS	DEG_SPOP_SBC_1	0.25
p.R539H	TCGA-B5-A3FC	UCEC	TCGA	VMSSS	DEG_SPOP_SBC_1	0.3056
p.R539H	DO41871	UCEC	ICGC	VMSSS	DEG_SPOP_SBC_1	0.3056
p.P553S	TCGA-CR-6484	HNSC	TCGA	VMSSS	DEG_SPOP_SBC_1	0.0833
p.P553S	DO15206	HNSC	ICGC	VMSSS	DEG_SPOP_SBC_1	0.0833
p.R539C	TCGA-QQ-A8VF	SARC	TCGA	VMSSS	DEG_SPOP_SBC_1	0.3056
p.P548Q	DO228948	LICA	ICGC	VMSSS	DEG_SPOP_SBC_1	0.2222
p.V540I	DO33043	PACA	ICGC	VMSSS	DEG_SPOP_SBC_1	0.7076
p.P535Q	DO220077	SARC	ICGC	VMSSS	DEG_SPOP_SBC_1	0.1944
p.G537D	DO229229	THCA	ICGC	VMSSS	DEG_SPOP_SBC_1	0.3611
p.A551T	SIDM00124	Kidney Carcinoma	GDSC	VMSSS	DEG_SPOP_SBC_1	0.1389
p.A551T	A498	kidney	COSMIC	VMSSS	DEG_SPOP_SBC_1	0.1389
p.P534A	ACH-000818	Breast Cancer	CCLE	VMSSS	DEG_SPOP_SBC_1	0.1667
p.S546R	ACH-000964	Leukemia	CCLE	VMSSS	DEG_SPOP_SBC_1	0.2778
p.S543L	ACH-000964	Leukemia	CCLE	VMSSS	DEG_SPOP_SBC_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49848	Transcription initiation factor TFIID subunit 6	DEG_SPOP_SBC_1	540:544	VMSSS	SPOP	0.9875	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	676:680	VMSSS	SPOP	0.9741	More...
Q8NF50	Dedicator of cytokinesis protein 8	DEG_SPOP_SBC_1	900:904	VMSSS	SPOP	0.99	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	239:243	VMSSS	SPOP	0.5358	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons