DegronMD

Uniprot ID: Q9H0E3

Source protein: Histone deacetylase complex subunit SAP130

Source gene: SAP130

Class: DEG_SPOP_SBC_1

Location: 239:243

E3 ligase: SPOP

DEGRON score: 0.5358

ASA_SCORE: 92.36

COIL: 0.9118

CONS_SCORE: 0.513

DSS_SCORE: 0.3626

HELIX: 0.0462

FCONS_SCORE: 0.9847

RIG_SCORE: 0.6904

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I243L	ACH-001560	Lung Cancer	CCLE	VMSSS	DEG_SPOP_SBC_1	0.7174
p.A237V	TCGA-DI-A1BU	UCEC	TCGA	VMSSS	DEG_SPOP_SBC_1	0.2778
p.A237V	DO42023	UCEC	ICGC	VMSSS	DEG_SPOP_SBC_1	0.2778
p.A235V	ACH-000989	Colon/Colorectal Cancer	CCLE	VMSSS	DEG_SPOP_SBC_1	0.2222
p.A235V	SNU-175	large_intestine	COSMIC	VMSSS	DEG_SPOP_SBC_1	0.2222
p.G233C	TCGA-EE-A183	SKCM	TCGA	VMSSS	DEG_SPOP_SBC_1	0.1667
p.G233C	DO37715	SKCM	ICGC	VMSSS	DEG_SPOP_SBC_1	0.1667
p.R232Q	TCGA-AP-A056	UCEC	TCGA	VMSSS	DEG_SPOP_SBC_1	0.1389
p.R232Q	DO43971	UCEC	ICGC	VMSSS	DEG_SPOP_SBC_1	0.1389
p.R250W	ACH-002097	Skin Cancer	CCLE	VMSSS	DEG_SPOP_SBC_1	0.1389
p.R250W	CP66-MEL	skin	COSMIC	VMSSS	DEG_SPOP_SBC_1	0.1389
p.H229Y	SIDM00216	Colorectal Carcinoma	GDSC	VMSSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 12 of 12 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	676:680	VMSSS	SPOP	0.9741	More...
Q8NF50	Dedicator of cytokinesis protein 8	DEG_SPOP_SBC_1	900:904	VMSSS	SPOP	0.99	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	239:243	VMSSS	SPOP	0.5358	More...
P49848	Transcription initiation factor TFIID subunit 6	DEG_SPOP_SBC_1	540:544	VMSSS	SPOP	0.9875	More...

Showing 1 to 4 of 4 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons