DegronMD - Q8NF50(DOCK8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S893T	TCGA-52-7809	LUSC	TCGA	VMSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.1389
p.M901V	TCGA-AX-A05Y	UCEC	TCGA	VMSSS	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.6097
p.D907Y	TCGA-AZ-6598	COAD	TCGA	VMSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.25
p.D907N	TCGA-BF-A1Q0	SKCM	TCGA	VMSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.25
p.H912N	TCGA-CG-5721	STAD	TCGA	VMSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.1111
p.A909T	TCGA-CV-7413	HNSC	TCGA	VMSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.1944
p.R899Q	TCGA-EY-A215	UCEC	TCGA	VMSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.3056
p.A909V	TCGA-EY-A549	UCEC	TCGA	VMSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.1944
p.S913Y	TCGA-FS-A1Z0	SKCM	TCGA	VMSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.0833
p.R908W	DO1015	BRCA	ICGC	VMSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.2222
p.R908W	DO218861	SKCA	ICGC	VMSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.2222
p.M894I	DO229018	LICA	ICGC	VMSSS	DEG_SPOP_SBC_1	900:904	Mutation blocking ubiquitination signal	0.6111
p.A895S	DO229038	LICA	ICGC	VMSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.1944
p.H899D	DO48478	LIHC	ICGC	VMSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.3056
p.M901T	DO23915	LUAD	ICGC	VMSSS	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.6312
p.R911H	DO49460	PACA	ICGC	VMSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.1389
p.V898I	DO41331	UCEC	ICGC	VMSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.2778
p.D914N	ACH-001669	Leukemia	CCLE	VMSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.0556
p.L905M	CW-2	large intestine	COSMIC	VMSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.3056

Kaplan plot for DOCK8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DOCK8

UniProt ID: Q8NF50

Entrez ID: 81704

Protein name: Dedicator of cytokinesis protein 8

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DOCK8 in