DegronMD

Uniprot ID: Q68DE3

Source protein: Basic helix-loop-helix domain-containing protein USF3

Source gene: USF3

Class: DEG_SPOP_SBC_1

Location: 1087:1091

E3 ligase: SPOP

DEGRON score: 0.9819

ASA_SCORE: 91.58

COIL: 0.9242

CONS_SCORE: 0.7233

DSS_SCORE: 0.6533

HELIX: 0.0246

FCONS_SCORE: 1.0633

RIG_SCORE: 0.5727

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1085N	SIDM02021	Esophageal Carcinoma	GDSC	PMSTS	DEG_SPOP_SBC_1	0.2778
p.R1096H	SIDM00150	Colorectal Carcinoma	GDSC	PMSTS	DEG_SPOP_SBC_1	0.1944
p.R1096H	KM12	large_intestine	COSMIC	PMSTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	1087:1091	PMSTS	SPOP	0.9819	More...
Q68DQ2	Very large A-kinase anchor protein	DEG_SPOP_SBC_1	55:59	PMSTS	SPOP	0.9792	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons