DegronMD

Uniprot ID: Q68DQ2

Source protein: Very large A-kinase anchor protein

Source gene: CRYBG3

Class: DEG_SPOP_SBC_1

Location: 55:59

E3 ligase: SPOP

DEGRON score: 0.9792

ASA_SCORE: 85.6

COIL: 0.8524

CONS_SCORE: 0.6001

DSS_SCORE: 0.7158

HELIX: 0.0666

FCONS_SCORE: 1.1567

RIG_SCORE: 0.601

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L59I	TCGA-AA-A022	COAD	TCGA	PMSTS	DEG_SPOP_SBC_1	0.7174
p.L59I	DO10647	COAD	ICGC	PMSTS	DEG_SPOP_SBC_1	0.7174
p.N48D	TCGA-AG-A002	READ	TCGA	PMSTS	DEG_SPOP_SBC_1	0.1389
p.A68T	TCGA-AZ-6607	COAD	TCGA	PMSTS	DEG_SPOP_SBC_1	0.5278
p.A68T	DO8522	COAD	ICGC	PMSTS	DEG_SPOP_SBC_1	0.5278
p.E54D	TCGA-D1-A3DA	UCEC	TCGA	PMSTS	DEG_SPOP_SBC_1	0.3056
p.E54D	DO229026	LICA	ICGC	PMSTS	DEG_SPOP_SBC_1	0.3056
p.E54D	DO43258	UCEC	ICGC	PMSTS	DEG_SPOP_SBC_1	0.3056
p.S49Y	DO8730	COAD	ICGC	PMSTS	DEG_SPOP_SBC_1	0.1667
p.S49Y	ACH-001991	Primary	CCLE	PMSTS	DEG_SPOP_SBC_1	0.1667
p.P55S	DO228245	LICA	ICGC	PMSTS	DEG_SPOP_SBC_1	0.6752
p.T58S	DO232025	LICA	ICGC	PMSTS	DEG_SPOP_SBC_1	0.7116
p.S67P	DO229213	THCA	ICGC	PMSTS	DEG_SPOP_SBC_1	0.5556
p.S50G	DO229232	THCA	ICGC	PMSTS	DEG_SPOP_SBC_1	0.1944
p.T58P	ACH-000780	Lung Cancer	CCLE	PMSTS	DEG_SPOP_SBC_1	0.8142
p.L59F	ACH-000810	Skin Cancer	CCLE	PMSTS	DEG_SPOP_SBC_1	0.6981
p.E56K	ACH-000996	Endometrial/Uterine Cancer	CCLE	PMSTS	DEG_SPOP_SBC_1	0.7022
p.A49V	ACH-001853	Bile Duct Cancer	CCLE	PMSTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	1087:1091	PMSTS	SPOP	0.9819	More...
Q68DQ2	Very large A-kinase anchor protein	DEG_SPOP_SBC_1	55:59	PMSTS	SPOP	0.9792	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons