DegronMD - Q68DQ2(CRYBG3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L754I	TCGA-2W-A8YY	CESC	TCGA	DSGNLS	DEG_SCF_TRCP1_1	764:769	Mutation rewiring degron network	0.0556
p.L754I	DO223732	CESC	ICGC	DSGNLS	DEG_SCF_TRCP1_1	764:769	Mutation rewiring degron network	0.0556
p.E630Q	TCGA-4Z-AA7W	BLCA	TCGA	ISETPLDS	DEG_SCF_FBW7_1	620:627	Mutation rewiring degron network	0.25
p.E630Q	DO218984	BLCA	ICGC	ISETPLDS	DEG_SCF_FBW7_1	620:627	Mutation rewiring degron network	0.25
p.S324I	TCGA-55-8204	LUAD	TCGA	NKENS	DEG_APCC_KENBOX_2	312:316	Mutation rewiring degron network	0.1111
p.S324I	DO45322	LUAD	ICGC	NKENS	DEG_APCC_KENBOX_2	312:316	Mutation rewiring degron network	0.1111
p.E1020K	TCGA-56-8625	LUSC	TCGA	SEDSSFLKVPSV	DEG_COP1_1	1023:1034	Mutation blocking phosphorylation signal	0.6944
p.E1020K	DO45515	LUSC	ICGC	SEDSSFLKVPSV	DEG_COP1_1	1023:1034	Mutation blocking phosphorylation signal	0.6944
p.G308V	TCGA-66-2795	LUSC	TCGA	NKENS	DEG_APCC_KENBOX_2	312:316	Mutation substituting flanking lysine	0.3333
p.G308V	DO26710	LUSC	ICGC	NKENS	DEG_APCC_KENBOX_2	312:316	Mutation substituting flanking lysine	0.3333
p.G636V	TCGA-A4-7583	KIRP	TCGA	ISETPLDS	DEG_SCF_FBW7_1	620:627	Mutation blocking phosphorylation signal	0.5278
p.G636V	DO20870	KIRP	ICGC	ISETPLDS	DEG_SCF_FBW7_1	620:627	Mutation blocking phosphorylation signal	0.5278
p.D779N	TCGA-A5-A1OF	UCEC	TCGA	DSGNLS	DEG_SCF_TRCP1_1	764:769	Mutation rewiring degron network	0.0556
p.D779N	DO42568	UCEC	ICGC	DSGNLS	DEG_SCF_TRCP1_1	764:769	Mutation rewiring degron network	0.0556
p.F613L	TCGA-A5-A2K5	UCEC	TCGA	ISETPLDS	DEG_SCF_FBW7_1	620:627	Mutation rewiring degron network	0.1389
p.F613L	DO41379	UCEC	ICGC	ISETPLDS	DEG_SCF_FBW7_1	620:627	Mutation rewiring degron network	0.1389
p.R615Q	TCGA-AA-3672	COAD	TCGA	ISETPLDS	DEG_SCF_FBW7_1	620:627	Mutation rewiring degron network	0.1944
p.R615Q	DO9010	COAD	ICGC	ISETPLDS	DEG_SCF_FBW7_1	620:627	Mutation rewiring degron network	0.1944
p.R615Q	DO228696	EOPC	ICGC	ISETPLDS	DEG_SCF_FBW7_1	620:627	Mutation rewiring degron network	0.1944
p.R615Q	DO42424	UCEC	ICGC	ISETPLDS	DEG_SCF_FBW7_1	620:627	Mutation rewiring degron network	0.1944
p.L59I	TCGA-AA-A022	COAD	TCGA	PMSTS	DEG_SPOP_SBC_1	55:59	Mutation altering degron motif	0.7174
p.L59I	DO10647	COAD	ICGC	PMSTS	DEG_SPOP_SBC_1	55:59	Mutation altering degron motif	0.7174
p.N48D	TCGA-AG-A002	READ	TCGA	PMSTS	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.1389
p.S916Y	TCGA-AP-A059	UCEC	TCGA	LKENC	DEG_APCC_KENBOX_2	903:907	Mutation rewiring degron network	0.0833
p.S916Y	DO41361	UCEC	ICGC	LKENC	DEG_APCC_KENBOX_2	903:907	Mutation rewiring degron network	0.0833
p.Q618H	TCGA-AP-A0LM	UCEC	TCGA	ISETPLDS	DEG_SCF_FBW7_1	620:627	Mutation blocking phosphorylation signal	0.7222
p.Q618H	DO43306	UCEC	ICGC	ISETPLDS	DEG_SCF_FBW7_1	620:627	Mutation blocking phosphorylation signal	0.7222
p.A70T	TCGA-AP-A1DV	UCEC	TCGA	KKENV	DEG_APCC_KENBOX_2	61:65	Mutation rewiring degron network	0.1944
p.A70T	DO43186	UCEC	ICGC	KKENV	DEG_APCC_KENBOX_2	61:65	Mutation rewiring degron network	0.1944
p.A70T	ACH-000920	Leukemia	CCLE	KKENV	DEG_APCC_KENBOX_2	61:65	Mutation rewiring degron network	0.1944
p.R71K	TCGA-AP-A1DV	UCEC	TCGA	KKENV	DEG_APCC_KENBOX_2	61:65	Mutation rewiring degron network	0.1667
p.R71K	DO43186	UCEC	ICGC	KKENV	DEG_APCC_KENBOX_2	61:65	Mutation rewiring degron network	0.1667
p.E905D	TCGA-AP-A1E0	UCEC	TCGA	LKENC	DEG_APCC_KENBOX_2	903:907	Mutation altering degron motif	0.6758
p.E905D	DO43154	UCEC	ICGC	LKENC	DEG_APCC_KENBOX_2	903:907	Mutation altering degron motif	0.6758
p.L911I	TCGA-AX-A1CE	UCEC	TCGA	LKENC	DEG_APCC_KENBOX_2	903:907	Mutation rewiring degron network	0.2222
p.L911I	DO42280	UCEC	ICGC	LKENC	DEG_APCC_KENBOX_2	903:907	Mutation rewiring degron network	0.2222
p.A68T	TCGA-AZ-6607	COAD	TCGA	KKENV	DEG_APCC_KENBOX_2	61:65	Mutation blocking phosphorylation signal	0.6944
p.A68T	TCGA-AZ-6607	COAD	TCGA	PMSTS	DEG_SPOP_SBC_1	55:59	Mutation blocking phosphorylation signal	0.5278
p.A68T	DO8522	COAD	ICGC	KKENV	DEG_APCC_KENBOX_2	61:65	Mutation blocking phosphorylation signal	0.6944
p.A68T	DO8522	COAD	ICGC	PMSTS	DEG_SPOP_SBC_1	55:59	Mutation blocking phosphorylation signal	0.5278
p.S625Y	TCGA-B5-A0K9	UCEC	TCGA	ISETPLDS	DEG_SCF_FBW7_1	620:627	Mutation altering degron motif	0.712
p.S625Y	DO42097	UCEC	ICGC	ISETPLDS	DEG_SCF_FBW7_1	620:627	Mutation altering degron motif	0.712
p.S1027I	TCGA-B5-A1MR	UCEC	TCGA	SEDSSFLKVPSV	DEG_COP1_1	1023:1034	Mutation altering degron motif	0.7341
p.S1027I	DO41758	UCEC	ICGC	SEDSSFLKVPSV	DEG_COP1_1	1023:1034	Mutation altering degron motif	0.7341
p.Q1015H	TCGA-BS-A0UV	UCEC	TCGA	SEDSSFLKVPSV	DEG_COP1_1	1023:1034	Mutation rewiring degron network	0.1111
p.Q1015H	DO42793	UCEC	ICGC	SEDSSFLKVPSV	DEG_COP1_1	1023:1034	Mutation rewiring degron network	0.1111
p.R755Q	TCGA-CA-6717	COAD	TCGA	DSGNLS	DEG_SCF_TRCP1_1	764:769	Mutation rewiring degron network	0.0833
p.R755Q	DO8264	COAD	ICGC	DSGNLS	DEG_SCF_TRCP1_1	764:769	Mutation rewiring degron network	0.0833
p.R755Q	ACH-001664	Gastric Cancer	CCLE	DSGNLS	DEG_SCF_TRCP1_1	764:769	Mutation rewiring degron network	0.0833
p.R71T	TCGA-CD-5813	STAD	TCGA	KKENV	DEG_APCC_KENBOX_2	61:65	Mutation rewiring degron network	0.1667
p.R71T	DO38259	STAD	ICGC	KKENV	DEG_APCC_KENBOX_2	61:65	Mutation rewiring degron network	0.1667
p.E54D	TCGA-D1-A3DA	UCEC	TCGA	KKENV	DEG_APCC_KENBOX_2	61:65	Mutation rewiring degron network	0.1389
p.E54D	TCGA-D1-A3DA	UCEC	TCGA	PMSTS	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.3056
p.E54D	DO229026	LICA	ICGC	KKENV	DEG_APCC_KENBOX_2	61:65	Mutation rewiring degron network	0.1389
p.E54D	DO229026	LICA	ICGC	PMSTS	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.3056
p.E54D	DO43258	UCEC	ICGC	KKENV	DEG_APCC_KENBOX_2	61:65	Mutation rewiring degron network	0.1389
p.E54D	DO43258	UCEC	ICGC	PMSTS	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.3056
p.R615W	TCGA-E2-A155	BRCA	TCGA	ISETPLDS	DEG_SCF_FBW7_1	620:627	Mutation rewiring degron network	0.1944
p.R615W	DO1707	BRCA	ICGC	ISETPLDS	DEG_SCF_FBW7_1	620:627	Mutation rewiring degron network	0.1944
p.T73I	TCGA-EE-A2GH	SKCM	TCGA	KKENV	DEG_APCC_KENBOX_2	61:65	Mutation rewiring degron network	0.1111
p.T73I	DO37643	SKCM	ICGC	KKENV	DEG_APCC_KENBOX_2	61:65	Mutation rewiring degron network	0.1111
p.W1017C	TCGA-EE-A2GH	SKCM	TCGA	SEDSSFLKVPSV	DEG_COP1_1	1023:1034	Mutation rewiring degron network	0.1667
p.W1017C	DO37643	SKCM	ICGC	SEDSSFLKVPSV	DEG_COP1_1	1023:1034	Mutation rewiring degron network	0.1667
p.E896Q	TCGA-EK-A2R8	CESC	TCGA	LKENC	DEG_APCC_KENBOX_2	903:907	Mutation rewiring degron network	0.1389
p.E896Q	DO51599	CESC	ICGC	LKENC	DEG_APCC_KENBOX_2	903:907	Mutation rewiring degron network	0.1389
p.D303E	TCGA-EO-A22R	UCEC	TCGA	NKENS	DEG_APCC_KENBOX_2	312:316	Mutation rewiring degron network	0.0833
p.D303E	DO42713	UCEC	ICGC	NKENS	DEG_APCC_KENBOX_2	312:316	Mutation rewiring degron network	0.0833
p.K917E	TCGA-EO-A22R	UCEC	TCGA	LKENC	DEG_APCC_KENBOX_2	903:907	Mutation substituting flanking lysine	0.1667
p.K917E	DO42713	UCEC	ICGC	LKENC	DEG_APCC_KENBOX_2	903:907	Mutation substituting flanking lysine	0.1667
p.Y1044F	TCGA-EO-A22U	UCEC	TCGA	SEDSSFLKVPSV	DEG_COP1_1	1023:1034	Mutation rewiring degron network	0.0556
p.Y1044F	DO43755	UCEC	ICGC	SEDSSFLKVPSV	DEG_COP1_1	1023:1034	Mutation rewiring degron network	0.0556
p.S316Y	TCGA-EO-A22X	UCEC	TCGA	NKENS	DEG_APCC_KENBOX_2	312:316	Mutation altering degron motif	0.6009
p.S316Y	DO43907	UCEC	ICGC	NKENS	DEG_APCC_KENBOX_2	312:316	Mutation altering degron motif	0.6009
p.S316Y	ACH-001991	Primary	CCLE	NKENS	DEG_APCC_KENBOX_2	312:316	Mutation altering degron motif	0.6009
p.E896D	TCGA-EO-A3AV	UCEC	TCGA	LKENC	DEG_APCC_KENBOX_2	903:907	Mutation rewiring degron network	0.1389
p.E896D	DO52412	UCEC	ICGC	LKENC	DEG_APCC_KENBOX_2	903:907	Mutation rewiring degron network	0.1389
p.S1020Y	TCGA-EY-A1GI	UCEC	TCGA	SEDSSFLKVPSV	DEG_COP1_1	1023:1034	Mutation blocking phosphorylation signal	0.6944
p.S1020Y	DO36881	READ	ICGC	SEDSSFLKVPSV	DEG_COP1_1	1023:1034	Mutation blocking phosphorylation signal	0.6944
p.S1020Y	DO41211	UCEC	ICGC	SEDSSFLKVPSV	DEG_COP1_1	1023:1034	Mutation blocking phosphorylation signal	0.6944
p.E1068K	TCGA-IR-A3LI	CESC	TCGA	VSSSS	DEG_SPOP_SBC_1	1060:1064	Mutation rewiring degron network	0.2222
p.E1068K	DO44400	CESC	ICGC	VSSSS	DEG_SPOP_SBC_1	1060:1064	Mutation rewiring degron network	0.2222
p.P314L	TCGA-OR-A5JJ	ACC	TCGA	NKENS	DEG_APCC_KENBOX_2	312:316	Mutation altering degron motif	0.7582
p.D1018G	DO224905	BRCA	ICGC	SEDSSFLKVPSV	DEG_COP1_1	1023:1034	Mutation substituting flanking lysine	0.3056
p.S49Y	DO8730	COAD	ICGC	PMSTS	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.1667
p.S49Y	ACH-001991	Primary	CCLE	PMSTS	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.1667
p.L1016S	DO9700	COAD	ICGC	SEDSSFLKVPSV	DEG_COP1_1	1023:1034	Mutation rewiring degron network	0.1389
p.Q324K	DO233625	GACA	ICGC	NKENS	DEG_APCC_KENBOX_2	312:316	Mutation rewiring degron network	0.1111
p.P55S	DO228245	LICA	ICGC	PMSTS	DEG_SPOP_SBC_1	55:59	Mutation altering degron motif	0.6752
p.R893I	DO228974	LICA	ICGC	LKENC	DEG_APCC_KENBOX_2	903:907	Mutation rewiring degron network	0.0556
p.T58S	DO232025	LICA	ICGC	PMSTS	DEG_SPOP_SBC_1	55:59	Mutation altering degron motif	0.7116
p.R897L	DO229015	LICA	ICGC	LKENC	DEG_APCC_KENBOX_2	903:907	Mutation substituting flanking lysine	0.2778
p.R897L	DO229031	LICA	ICGC	LKENC	DEG_APCC_KENBOX_2	903:907	Mutation substituting flanking lysine	0.2778
p.E1024D	DO229024	LICA	ICGC	SEDSSFLKVPSV	DEG_COP1_1	1023:1034	Mutation altering degron motif	0.5647
p.R320H	DO23176	LINC	ICGC	NKENS	DEG_APCC_KENBOX_2	312:316	Mutation rewiring degron network	0.2222
p.N767K	DO46372	OV	ICGC	DSGNLS	DEG_SCF_TRCP1_1	764:769	Mutation altering degron motif	0.5806
p.S1059I	DO218860	SKCA	ICGC	VSSSS	DEG_SPOP_SBC_1	1060:1064	Mutation rewiring degron network	0.3056
p.L911F	DO37659	SKCM	ICGC	LKENC	DEG_APCC_KENBOX_2	903:907	Mutation rewiring degron network	0.2222
p.A898T	DO229264	THCA	ICGC	LKENC	DEG_APCC_KENBOX_2	903:907	Mutation rewiring degron network	0.1944
p.S67P	DO229213	THCA	ICGC	KKENV	DEG_APCC_KENBOX_2	61:65	Mutation blocking phosphorylation signal	0.7222
p.S67P	DO229213	THCA	ICGC	PMSTS	DEG_SPOP_SBC_1	55:59	Mutation blocking phosphorylation signal	0.5556
p.S50G	DO229232	THCA	ICGC	PMSTS	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.1944
p.Y2266C	SIDM01099	Neuroblastoma	GDSC	LSPFIE	LIG_APCC_ABBA_1	2276:2281	Mutation rewiring degron network	0.0556
p.Y2266C	SIDM01664	Prostate Carcinoma	GDSC	LSPFIE	LIG_APCC_ABBA_1	2276:2281	Mutation rewiring degron network	0.0556
p.S75F	ACH-000578	Lung Cancer	CCLE	KKENV	DEG_APCC_KENBOX_2	61:65	Mutation rewiring degron network	0.0556
p.K1039N	ACH-000623	Brain Cancer	CCLE	SEDSSFLKVPSV	DEG_COP1_1	1023:1034	Mutation substituting flanking lysine	0.3056
p.N1019Y	ACH-000657	Ovarian Cancer	CCLE	SEDSSFLKVPSV	DEG_COP1_1	1023:1034	Mutation rewiring degron network	0.2222
p.T58P	ACH-000780	Lung Cancer	CCLE	PMSTS	DEG_SPOP_SBC_1	55:59	Mutation altering degron motif	0.8142
p.L59F	ACH-000810	Skin Cancer	CCLE	PMSTS	DEG_SPOP_SBC_1	55:59	Mutation altering degron motif	0.6981
p.G900C	ACH-000958	Colon/Colorectal Cancer	CCLE	LKENC	DEG_APCC_KENBOX_2	903:907	Mutation rewiring degron network	0.25
p.T1014I	ACH-000982	Colon/Colorectal Cancer	CCLE	SEDSSFLKVPSV	DEG_COP1_1	1023:1034	Mutation rewiring degron network	0.0833
p.T1014I	ACH-001345	Colon/Colorectal Cancer	CCLE	SEDSSFLKVPSV	DEG_COP1_1	1023:1034	Mutation rewiring degron network	0.0833
p.G304R	ACH-000988	Endometrial/Uterine Cancer	CCLE	NKENS	DEG_APCC_KENBOX_2	312:316	Mutation rewiring degron network	0.1111
p.E56K	ACH-000996	Endometrial/Uterine Cancer	CCLE	PMSTS	DEG_SPOP_SBC_1	55:59	Mutation altering degron motif	0.7022
p.D765Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	DSGNLS	DEG_SCF_TRCP1_1	764:769	Mutation altering degron motif	0.7325
p.S1059C	ACH-001347	Head and Neck Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	1060:1064	Mutation rewiring degron network	0.3056
p.Q778E	ACH-001411	Bladder Cancer	CCLE	DSGNLS	DEG_SCF_TRCP1_1	764:769	Mutation rewiring degron network	0.0833
p.E1017G	ACH-001525	Cervical Cancer	CCLE	SEDSSFLKVPSV	DEG_COP1_1	1023:1034	Mutation rewiring degron network	0.1667
p.L911R	ACH-001664	Gastric Cancer	CCLE	LKENC	DEG_APCC_KENBOX_2	903:907	Mutation rewiring degron network	0.2222
p.A49V	ACH-001853	Bile Duct Cancer	CCLE	PMSTS	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.1667
p.Y1066C	ACH-002026	Endometrial/Uterine Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	1060:1064	Mutation rewiring degron network	0.2778
p.N896K	ACH-002233	Colon/Colorectal Cancer	CCLE	LKENC	DEG_APCC_KENBOX_2	903:907	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CRYBG3

UniProt ID: Q68DQ2

Entrez ID: 131544

Protein name: Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CRYBG3 in