DegronMD

Uniprot ID: Q68DQ2

Source protein: Very large A-kinase anchor protein

Source gene: CRYBG3

Class: DEG_SCF_FBW7_1

Location: 620:627

E3 ligase: FBXW7

DEGRON score: 0.8669

ASA_SCORE: 88.975

COIL: 0.8146

CONS_SCORE: 0.7724

DSS_SCORE: 0.6143

HELIX: 0.0575

FCONS_SCORE: 1.0545

RIG_SCORE: 0.6442

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E630Q	TCGA-4Z-AA7W	BLCA	TCGA	ISETPLDS	DEG_SCF_FBW7_1	0.25
p.E630Q	DO218984	BLCA	ICGC	ISETPLDS	DEG_SCF_FBW7_1	0.25
p.G636V	TCGA-A4-7583	KIRP	TCGA	ISETPLDS	DEG_SCF_FBW7_1	0.5278
p.G636V	DO20870	KIRP	ICGC	ISETPLDS	DEG_SCF_FBW7_1	0.5278
p.F613L	TCGA-A5-A2K5	UCEC	TCGA	ISETPLDS	DEG_SCF_FBW7_1	0.1389
p.F613L	DO41379	UCEC	ICGC	ISETPLDS	DEG_SCF_FBW7_1	0.1389
p.R615Q	TCGA-AA-3672	COAD	TCGA	ISETPLDS	DEG_SCF_FBW7_1	0.1944
p.R615Q	DO9010	COAD	ICGC	ISETPLDS	DEG_SCF_FBW7_1	0.1944
p.R615Q	DO228696	EOPC	ICGC	ISETPLDS	DEG_SCF_FBW7_1	0.1944
p.R615Q	DO42424	UCEC	ICGC	ISETPLDS	DEG_SCF_FBW7_1	0.1944
p.Q618H	TCGA-AP-A0LM	UCEC	TCGA	ISETPLDS	DEG_SCF_FBW7_1	0.7222
p.Q618H	DO43306	UCEC	ICGC	ISETPLDS	DEG_SCF_FBW7_1	0.7222
p.S625Y	TCGA-B5-A0K9	UCEC	TCGA	ISETPLDS	DEG_SCF_FBW7_1	0.712
p.S625Y	DO42097	UCEC	ICGC	ISETPLDS	DEG_SCF_FBW7_1	0.712
p.R615W	TCGA-E2-A155	BRCA	TCGA	ISETPLDS	DEG_SCF_FBW7_1	0.1944
p.R615W	DO1707	BRCA	ICGC	ISETPLDS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DQ2	Very large A-kinase anchor protein	DEG_SCF_FBW7_1	620:627	ISETPLDS	FBXW7	0.8669	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons